The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also examined. In the case of microcrystalline cellulose, a higher concentration of glyceryl dibehenate increased the strength of tablets, while this did not occur in the case of spray-dried lactose. Increasing concentration of glyceryl dibehenate prolonged the release of salicylic acid; however, no statistically significant difference was found compared to the type of the dry binder used
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1. I. Singh P. Kumar N. Rani and V. Rana Investigation of diff erent lipid based materials as matrices designed to control the release of a hydrophobic drug Int. J. Pharm. Sci. Drug Res. 1 (2009) 158-163.
2. GATTEFOSSE Lipid excipients for oral dosage forms Documents for Oral route. h_ p://www.ga_ efosse. com/en/document-center/; last access July 15 2013.
3. S. H. A. El-Halim M. M. Amin O. N. El-Gazayerly and N. A. A. El-Gavad Comparative study on the diff erent techniques for the preparation of sustained-release hydrophobic matrices of a highly water-soluble drug Drug Discov. Ther. 4 (2010) 484-492.
4. L. M. E. McIndoe Glyceryl Dibehenate in Handbook of Pharmaceutical Excipients (Eds. R. C. Rowe P. J. Sheskey and S. C. Owen) 5th ed. Pharmaceutical Press Washington 2006 pp. 304-305.
5. GATTEFOSSE Developing sustained release tablets with CompritolR 888 ATO Formulation Guidelines Version 2 Lyon 2010.
6. G. Ragnarsson Force-displacement and Network Measurements in Pharmaceutical Powder Compac tion Technology (Eds. G. Alderborn and Ch. Nystrom Marcel Dekker Inc. New York 1996 pp. 77-96.
7. A. Stamm and C. Mathis Verpressbarkeit von Festen Hilfsstoff en fur Direk_ able_ ierung Acta Pharm. Technol. 22 (1976) 7-16.
8. J. T. Fell and J. M. Newton Determination of tablet strength by diametral-compression test J. Pharm. Sci. 59 (1970) 688-691; DOI: 10.1002/jps.2600590523.
9. European Pharmacopoeia 7th ed. Vol. 1 Council of Europe Strasbourg 2010 pp. 256-263.
10. V. A. Belousov Choice of optimal pressure values in tableting medicinal powders Khim. Farm. Zh. 10 (1976) 105-111.
11. B. A. C. Carlin Direct Compression and the Role of Filler Binders in Pharmaceutical Dosage Forms: Tablets Eds. L. L. Augsburger and S. W. Hoag) 3th ed. Informa Healthcare USA Inc. New York 2008 Vol. 2 pp. 173-216.
12. N. O. Iloanusi and J. B. Schwartz The eff ect of wax on compaction of microcrystalline cellulose beads made by extrusion and spheronization Drug Dev. Ind. Pharm. 24 (1998) 37-44; DOI: 10.3109/03639049809082350.
13. M. Roberts D. Vellucci S. Mostafa C. Miolane and D. Marchaud Development and evaluation of sustained-release CompritolR 888 ATO matrix mini-tablets Drug Dev. Ind. Pharm. 38 (2012) 1068-1076; DOI: 10.3109/03639045.2011.638302.
14. P. Costa and J. M. Sousa Lobo Modeling and comparison of dissolution profiles Eur. J. Pharm. Sci. 13 (2001) 123-133; DOI: 10.1016/S0928-0987(01)00095-1.