A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations

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A sensitive spectrophotometric method for the determination of sulfonamides in pharmaceutical preparations

A new, simple and sensitive spectrophotometric method for the determination of some sulfonamide drugs has been developed. The method is based on the diazotization of sulfacetamide, sulfadiazine, sulfaguanidine, sulfamerazine, sulfamethazine, sulfamethoxazole, and their coupling with 8-hydroxyquinoline in alkaline media to yield red coloured products with absorption maxima at 500 nm. Beer's law is obeyed from 0.1--7.0 μg mL-1. The limits of quantification and limits of detection were 0.11--0.18 and 0.03--0.05 μg mL-1, respectively. Intraday precision (RSD 0.1--0.5%) and accuracy (recovery 97.3--100.8%) of the developed method were evaluated. No interference was observed from common adjuvants. The method has been successfully applied to the assay of sulpha drug in pharmaceutical formulations.

L. A. Mitscher, Antibiotics and Antimicrobial Agents, in Foye's Principles of Medicinal Chemistry (Eds. D. A. Williams and T. L. Lemke), 5th ed., Lippincott Williams and Wilkins, Philadelphia 2002, pp. 819--862.

W. A. Petri, Jr., Antimicrobial Agents, in Goodman and Gilman's Pharmacological Basis of Therapeutics (Eds. J. G. Hardman and Lee E. Limbird), 10th Ed., McGraw Hill, New York 2001, pp. 1171--1188.

J. M. Beale, Jr., Anti Infective Agents, in Wilson and Gisvold's Text Book of Organic Medicinal and Pharmaceutical Chemistry (Eds. J. H. Block and J. M. Beale, Jr.), 11th ed., Lippincott William and Wilkins, Philadélphia 2004, pp. 217--281.

British Pharmacopoeia, Vol II, Her Majesty's Stationery Office, London 2004, pp. 1858--1859.

B. Chivarino, M. A. Crestoni, A. Di-Marzio and S. Fornarini, Determination of sulfonamide antibiotics by gas chromatography coupled with atomic emission detection, J. Chromatogr. Biomed. Appl.706 (1998) 269--277; DOI: 10.1016/S0378--4347(97)00568--9.

F. M. El Anwar, A. M. El Walily, M. H. Abdel Hay and M. El Swify, The analysis of a triple sulfonamide in pharmaceutical powder form by HPLC, Anal. Lett.24 (1991) 767--779; DOI: 10.1080/00032719108052941.

G. K. Thomas, R. G. Millar and P. W. Antis, Stability of sulfonamide antibiotics in spiked pig liver tissue during frozen storage, JAOAC Int.80 (1997) 988--995.

G. Knupp, H. Pollmann and D. Jonas, An improved HPTLC method for the rapid identification and quantification of sulfonamides, Chromatographia22 (1986) 21--24; DOI: 10.1007/BF02257291.

C. L. Flurer, Analysis of antibiotics by capillary electrophoresis, Electrophoresis18 (1997) 2427--2437; DOI: 10.1002/elps.1150181233.

F. Malecki and V. Starosak, Potentiometric determination of sulfonamides with a silver sulfide electrode, Anal. Chim. Acta139 (1982) 353--357; DOI:10.1016/S0003--2670(01)94015-2.

M. T. Ackermans, J. L. Beckers, F. M. Everaerts, H. Hoogland and M. J. H. Tomassen, Determination of sulphonamides in pork meat extracts by capillary zone electrophoresis, J. Chromatogr.596 (1992) 101--109; DOI: 10.1016/0021-9673(92)80209-D.

T. A. M. Msagati and J. C. Ngila, Voltammetric detection of sulfonamides at a poly(3-methylthiophene) electrode, Talanta58 (2002) 605--610; DOI: 10.1016/S0039-9140(02)00327-2.

E. Martlbauer, E. Usleber, E. Schneider and R. Dietrich, Immunochemical detection of antibiotics and sulfonamides, Analyst119 (1994) 2543--2548; DOI: 10.1039/AN9941902543.

S. W. Garden and P. Sporns, Development and evaluation of an enzyme immunoassay for sulfamerazine in milk, J. Agric. Food Chem.42 (1994) 1379--1391; DOI: 10.1021/jf00042a026.

M. S. Pena, F. Salinas, M. C. Mahendero and J. J. Aaron, Spectrofluorimetric determination of sulphonamides in pharmaceutical compounds and foods, J. Pharm. Biomed. Anal.10 (1992) 805--808; DOI:10.1016/0731-7085(91)80084-M.

Y. M. Issa, A. L. El. Ansary and W. Selim, Enthalpimetric determination of sulfa drugs in pure form and pharmaceutical formulations, Anal. Lett.31 (1998) 131--146; DOI: 10.1080/00032719808001838.

W. S. Sutherland, J. J. Laserna, M. J. Angebranndt and J. D. Winefordner, Surface-enhanced Raman analysis of sulfa drugs on colloidal silver dispersion, Anal. Chem.62 (1990) 689--693; DOI: 10.1021/ac00206a008.

P. Nagaraja, K. R. Sunitha, R. A. Vasantha and H. S. Yathirajan, Iminodibenzyl as a novel coupling agent for the spectrophotometric determination of sulfonamide derivatives, Eur. J. Pharm. Biopharm.53 (2002) 187--192; DOI:10.1016/S0939--6411(01)00235-1.

P. Nagaraja, H. S. Yathirajan, C. R. Raju, R. A. Vasantha, M. S. Hemantha Kumar and P. Nagendra, 3-Aminophenol as a novel coupling agent for the spectrophotometric determination of sulfonamide derivatives, Farmaco58 (2003) 1295--1300; DOI: 10.1016/S0014-827X (03) 00093-4.

S. Raghuveer, I. R. K. Raju, D. K. Vastu and C. M. R. Shrivastava, Colorimetric determination of sulphamethoxazole in pharmaceutical preparations, Indian Drugs30 (1993) 132--135.

A. S. Amin and M. M. Zarch, Acetylacetone-formaldehyde reagent for the spectrophotometric determination of some sulfa drugs in pure and dosage forms, Mikrochim. Acta.124 (1996) 227--233; DOI: 10.1007/BF01242820.

S. S. Sabry, Enhanced spectrophotometry of sulfonamides with 2-acetylbutyrolactone derivatives, Anal. Lett.39 (2006) 2591--2615; DOI: 10.1080/00032710600824748.

ICH Topic Q2(R1), Validation of Analytical Procedures: Text and Methodology (CPMP/ICH/281/95) acessed October 27, 2006.

R. A. Day, Jr. and A. L. Underwood, Errors and the Treatment of Analytical Data, in Quantitative Analysis, 6th ed., Prentice-Hall of India, New Delhi 1999, pp. 7--42.

A. M. Mohamed, H. F. Askal and G. M. Saleh, Use of p-benzoquinone for the spectrophotometric determination of certain sulphonamides, J. Pharm. Biomed. Anal.9 (1991) 531--538; DOI: 10.1016/0731-7085(91) 80174-8.

G. R. Rao, S. S. N. Murthy, P. J. Rao and I. R. K. Raju, Spectrophotometric determination of sulphacetamide sodium with ℴ-chloranil in dosage form, Indian J. Pharm. Sci.50 (1988) 138--140.

A. G. Fogg and N. M. Fayad, Spectrophotometric and differential pulse polarographic determination of sulphaguanidine by reaction with hypochlorite and phenol, Anal. Chim. Acta.106 (1979) 365--367; DOI:10.1016/S0003-2670(01)85022-4.

P. Nagaraja, H. S. Yathirajan, K. R. Sunitha and R. A. Vasantha, A new sensitive and rapid spectrophotometric method for the determination of sulfa drugs, JAOAC Int.85 (2002) 869--874.

Acta Pharmaceutica

The Journal of Croatian Pharmaceutical Society

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