Prostate cancer usually metastasis to the regional lymph nodes and can rarely metastases to nonregional supradiaphragmatic lymph nodes. Cervical lymph node metastasis of prostate cancer is extremely rare. However, it should be considered in the differential diagnosis of cervical lymphadenopathy in male patients with adenocarcinoma of unknown primary site. In this report we present a rare case of metastatic prostate adenocarcinoma with left supraclavicular lymphadenopathy as the only clinical presentation with no other evidence of metastasis to the regional lymph nodes or bone metastasis.
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1. Copeland B Clark JM Sura A Kilpatrick SE Shockley W Meredith S. Prostate carcinoma metastatic to the cervical lymph nodes: report of two cases and review of the literature. American journal of otolaryngology. 2001; 22(6):420-3.
2. Ogunyemi O Rojas A Hematpour K Rogers D Head C Bennett C. Metastasis of genitourinary tumors to the head and neck region. European Archives of Oto-Rhino-Laryngology. 2010; 267(2):273-9.
3. Ferlay J Steliarova-Foucher E Lortet-Tieulent J Rosso S Coebergh JW Comber H Forman D Bray F. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. European journal of cancer. 2013; 49(6):1374-403.
4. Venable DD Hastings D Misra RP. Unusual metastatic patterns of prostate adenocarcinoma. The Journal of urology. 1983; 130(5):980-5.
5. MINTZ ER SMITH GG. Autopsy findings in 100 cases of prostatic cancer. New England Journal of Medicine. 1934; 211(11):479-87.
6. Flocks RH Boatman DL. Incidence of head and neck metastases from genito urinary neoplasms. The laryngoscope. 1973; 83(9):1527-39.
7. Hematpour K Bennett CJ Rogers D Head CS. Supraclavicular lymph node: incidence of unsuspected metastatic prostate cancer. European Archives of Oto-Rhino-Laryngology and Head & Neck. 2006; 263(9):872-4.
8. Chan G Domes T. Supraclavicular lymphadenopathy as the initial presentation of metastatic prostate cancer: A case report and review of literature. Canadian Urological Association Journal. 2013; 7(5- 6):E433.
9. Butler JJ Howe CD Johnson DE. Enlargement of the supraclavicular lymph nodes as the initial sign of prostatic carcinoma. Cancer. 1971; 27(5):1055-63.
10. Jones H Anthony PP. Metastatic prostatic carcinoma presenting as left sided cervical lymphadenopathy: a series of 11 cases. Histopathology. 1992; 21(2):149-54.
11. Wang HJ Chiang PH Peng JP Yu TJ. Presentation of prostate carcinoma with cervical lymphadenopathy: report of three cases. Chang Gung Med J. 2004; 27(11):840-4.