Effects of high-energy ionizing radiation on organ systems in human medicine

The aim of our study was to investigate acute post-radiation changes after therapy with ionizing radiation manifested by erythema or dry, squamous and scurfy skin on a breast. We observed 100 female patients suffering from an early stage of breast carcinoma. The entering criteria were: age below 70 years, 100% of the Karnofsky s Score, no tumor bilaterality, tumor in the stage of T1 or T2. The female patients had finished nonradical surgery consisting from quadrantectomy and deviation of the axilla. Our results showed relationships between the localization and the level of breast skin change as well as between adjuvant chemotherapy and the level of breast skin change and, finally, between the size of the average dose of high energy radiation and the level of breast skin change.