Synthesis of 2-(2-(4-Phenyl-2,3-Dihydrobenzo[B][1,4]Thiazepin-2-YL) Phenoxy)-N-(P-Tolyl)Acetamide

Open access


The A new benzothiazepine’s derivative names N-(p-tolyl)-2-(2-(4-phenyl-2,3-dihydrobenzo[b][1,4]thiazepin-2-yl)phenoxy)acetamide was synthesized by reaction of o-aminothiophenol and N-(p-tolyl)-2-(2-(3-oxo-3-phenylprop-1-en-1-yl)phenoxy)acetamide, which was prepared from salicylaldehyde and acetophenone through (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one. The structures of the compounds were determined by IR, 1H-NMR, 13C-NMR and HR-MS spectral data.

1. Won, S. J.; Liu, C. T.; Tsao, L. T.; Weng, J. R.; Ko, H. H.; Wang, J. P.; Lin, C. N. Synthetic chalcones as potential anti-inflammatory and cancer chemopreventive agents. Eur. J. Med. Chem. 2005, 40, 103–112.

2. Syam, S.; Abdelwahab, S. I.; Al-Mamary, M. A.; Mohan, S. Synthesis of chalcones with anticancer activities. Mol. 2012, 17, 6179–6195.

3. Venkatachalam, H.; Nayak, Y.; Jayashree, B. S. Synthesis, characterization and antioxidant activities of synthetic chalcones and flavones. APCBEE Proc. 2012, 3, 209–213.

4. Hsieh, C. T.; Hsieh, T. J.; Shazly, E. M.; Chuang, D. W.; Tsai, Y. H.; Yen, C. T.; Wu, S. F.; Wu, Y. C.; Chang, F. R. Synthesis of chalcone derivatives as potential anti-diabetic agents. Bioorg. Med. Chem. Lett. 2012, 22, 3912–3915.

5. Wang, L.; Zhang, P.; Zhang, X.; Zhang, Y.; Li, Y.; Wang, Y. Synthesis and biological evaluation of a novel series of 1,5-benzothiazepine derivatives as potential antimicrobial agents. Eur. J. Med. Chem. 2009, 44, 2815–2821.

6. Cherkupally, S. R.; Gurrala, P. R.; Adki, N.; Avula, S. Synthesis and biological study of novel methylene-bis-benzofuranyl-[1,5]-benzothiazepines. Org. Commun. 2008, 4, 84–94.

7. Renuka, N.; Pavithra, G.; Ajay Kumar, K. Synthesis and their antioxidant activity studies of 1, 4-benzothiazepine analogues. Der. Pharma. Chem. 2014, 6, 482–485.

8. Garg, N.; Chandra, T.; Jain, A. B.; Kumar, A. Synthesis and evaluation of some new substituted benzothiazepine and benzoxazepine derivatives as anticonvulsant agents. Eur. J. Med. Chem. 2010, 45, 1529–1553.

9. Ameta, K. L.; Rathore, N. S.; Kumar, B. Synthesis and preliminary evaluation of novel 1, 5-. benzothiazepine derivatives as anti-lung cancer agents. Int. J. Pharm. 2013, 3, 328–333.

10. Saha, P.; Biswas, A.; Molleti, N.; Singh, V. K. Enantioselective synthesis of highly substituted chromans via the oxa-michael-michael cascade reaction with a bifunctional organocatalyst. J. Org. Chem. 2015, 80, 11115–11122.

Acta Chemica Iasi

The Journal of "Alexandru Ioan Cuza" University from Iasi

Journal Information


All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 82 82 21
PDF Downloads 55 55 13