Historical background of umbilical stem cell culture

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Umbilical cord is a waste material, and therefore does not raise ethical concerns related to its use for research and medicine. Stem cells from umbilical cord have a significant advantage over cells from other sources. First, the umbilical cord is an infinite source of stem cells, because it can be taken theoretically during each delivery. Secondly, acquisition of umbilical cord is a non-invasive, safe procedure for mother and child. Thirdly, the transplantation of umbilical cord stem cells is associated with a lower risk of infection and a less-frequent “graft versus host” reaction. In this work, the authors present a historical background of research on the cell from its discovery to modern times characterized by highly advanced methods of obtaining stem cells from umbilical cord and from other sources.

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  • 1. Olszewska-Słonina DM Drewa TA. Cell culture tissue engineering and regenerative medicine. Part I. Wiadomosci Lek Wars Pol. 1960;59:585–9.

  • 2. Gest H. The remarkable vision of Robert Hooke (1635-1703): first observer of the microbial world. Perspect Biol Med. 2005;48:266–72; DOI:10.1353/pbm.2005.0053.

  • 3. Vasil IK. A history of plant biotechnology: from the Cell Theory of Schleiden and Schwann to biotech crops. Plant Cell Rep. 2008;27:1423–40; DOI:10.1007/s00299-008-0571-4.

  • 4. Sonig A Gandhi V Nanda A. From the cell of Schwann to schwannoma--a century’s fruition. World Neurosurg. 2014;82:906–11; DOI:10.1016/j.wneu.2014.05.038.

  • 5. Thorpe T. History of plant tissue culture. Methods Mol Biol Clifton NJ. 2012;877:9–27; DOI:10.1007/978-1-61779-818-4_2.

  • 6. Moore B. In Memory of Sidney Ringer [1835-1910]: Some account of the Fundamental Discoveries of the Great Pioneer of the Bio-Chemistry of Crystallo-colloids in Living Cells. Biochem J. 1911;5:i.b3-xix; DOI:10.1042/bj005000i.

  • 7. Laubry C. [Justin Jolly (1870-1953)]. Rev Hematol. 1953;8:230–4

  • 8. Freshney R. Culture of Animal Cells: A Manual of Basic Technique and Specialized Applications Sixth Edition. 2010;346; DOI:10.1002/9780470649367.

  • 9. Harrison RG Greenman MJ Mall FP Jackson CM. Observations of the living developing nerve fiber. Anat Rec. 1907;1:116–28; DOI:10.1002/ar.1090010503.

  • 10. Maienschein J. Ross Granville Harrison (1870-1959) and perspectives on regeneration. J Exp Zoolog B Mol Dev Evol. 2010;314:607–15; DOI:10.1002/jez.b.21368.

  • 11. Gähwiler BH. Nerve cells in culture: the extraordinary discovery by Ross Granville Harrison. Brain Res Bull. 1999;50:343–4.

  • 12. Carrel A. On the permanent life of tissues outside of the organism. J Exp Med. 1912;15:516–28; DOI:10.1084/jem.15.5.516.

  • 13. Ebeling AH. The permanent life of connective tissue outside of the organism. J Exp Med. 1913;17:273–85; DOI:10.1084/jem.17.3.273.

  • 14. Pai-Dhungat JV Parikh F. Alexis Carrel (1873-1944). J Assoc Physicians India. 2015;63:94–5.

  • 15. Kumar P Murphy FA. Who is this man? Francis Peyton Rous. Emerg Infect Dis. 2013;19:661–3; DOI:10.3201/eid1904.130049.

  • 16. Jones HW McKusick VA Harper PS Wuu KD. George Otto Gey. (1899-1970). The HeLa cell and a reappraisal of its origin. Obstet Gynecol. 1971;38:945–9.

  • 17. Jiménez N Krouwer VJD Post JA. A new rapid and reproducible method to obtain high quality endothelium in vitro. Cytotechnology. 2013;65:1–14; DOI:10.1007/s10616-012-9459-9.

  • 18. Evans MJ Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292:154–6.

  • 19. Ballen KK Gluckman E Broxmeyer HE. Umbilical cord blood transplantation: the first 25 years and beyond. Blood. 2013;122:491–8; DOI:10.1182/blood-2013-02-453175.

  • 20. Bielec B Stojko R. Stem cells of umbilical blood cord - therapeutic use. Postepy Hig Med Doswiadczalnej Online. 2015;69:853–63.

  • 21. Piskorska-Jasiulewicz MM Witkowska-Zimny M. Perinatal sources of stem cells. Postepy Hig Med Doswiadczalnej Online. 2015;69:327–34; DOI:10.5604/17322693.1143052.

  • 22. Macierzystych PBK. Lista przeszczepień PBKM - PBKM n.d. https://www.pbkm.pl/o-komorkach-macierzystych/gdzie-wykorzystuje-sie-komorki-macierzyste/przeszczepienia-pbkm (accessed May 13 2019).

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