Biochemical Changes Occuring in Neonates with Sepsis

Open access


This retrospective study aims to analyze the relationship between biochemical changes occurring in newborns with sepsis proven by positive blood culture (BC) and possible correlations with 1 min Apgar score, 5 min Apgar score, gestational age (GA), and birth weight (BW). We included in the study all infants ≤7 days of life with positive BC that were admitted to the Neonatal Intensive Care Unit (NICU) and Neonatology Department (ND) of the County Emergency Clinical Hospital of Târgu Mureş, a tertiary level hospital, between 2014-2018. The analyzed parameters are: day of life for blood sampling (0-7 days of life), gender, Apgar score (1 and 5 minute), GA, BW, urea, creatinine, total bilirubin, direct bilirubin, aspartate aminotransferase (AST/GOT), alanine aminotransferase (ALT/GPT), c-reactive protein (CPR), bacteria involved, empiric antibiotics administered before blood sampling, temperature of the newborn on the day of BC. We found there is a statistically significant negative correlation between 1 and 5 min Apgar score and creatinine, between GA and urea and also between BW, GA and Direct Bilirubin. We found a statistically significant positive correlation between BW, GA and GPT.

If the inline PDF is not rendering correctly, you can download the PDF file here.

  • 1. Agras PI Tarcan A Baskin E Cengiz N Gürakan B Saatci U (2004) Acute renal failure in the neonatal period. Renal failure 26(3):305-309.

  • 2. Bolat F Comert S Bolat G Kucuk O Can E Bulbul A Nuhoglu A (2013) Acute kidney injury in a single neonatal intensive care unit in Turkey. World Journal of Pediatrics 9(4):323-329.

  • 3. Chand N Sanyal AJ (2007) Sepsis-induced cholestasis. Hepatology 45(1):230-241.

  • 4. Cortese F Scicchitano P Gesualdo M Filaninno A De Giorgi E Schettini F Ciccone MM (2016) Early and late infections in newborns: where do we stand? A review. Pediatrics & Neonatology 57(4):265-273.

  • 5. Hofer N Zacharias E Müller W Resch B (2012) An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology 102(1):25-36.

  • 6. Hug L Alexander M You D Alkema L (2019) National regional and global levels and trends in neonatal mortality between 1990 and 2017 with scenario-based projections to 2030: a systematic analysis. The Lancet Global Health 7(6):e710-e720.

  • 7. Hyde TB Hilger TM Reingold A Farley MM O’Brien KL Schuchat A (2002) Trends in incidence and antimicrobial resistance of early-onset sepsis: population-based surveillance in San Francisco and Atlanta. Pediatrics 110(4):690-695.

  • 8. Janković B Pasić S Marković M Veljković D Milicić M (2001) C-reactive protein concentrations during initial (empiric) treatment of neonatal sepsis. Srpski arhiv za celokupno lekarstvo 129:17-22.

  • 9. Mannan MA Shahidullah M Noor MK Islam F Alo D Begum NA (2010) Utility of C-reactive protein and hematological parameters in the detection of neonatal sepsis. Mymensingh medical journal: MMJ 19(2):259-263.

  • 10. Mathur NB Agarwal HS Maria A (2006) Acute renal failure in neonatal sepsis. The Indian Journal of Pediatrics 73(6):499-502.

  • 11. Newborns: reducing mortality (2018). In: World Health Organization site. Accessed 10 Jul 2019

  • 12. Ng PC Lam HS (2006) Diagnostic markers for neonatal sepsis. Current opinion in pediatrics 18(2):125-131.

  • 13. Oswari H Widjaja RK Rohsiswatmo R Cleghorn G (2013) Prognostic value of biochemical liver parameters in neonatal sepsis-associated cholestasis. Journal of paediatrics and child health 49(1):E6-E11.

  • 14. Resende DS Peppe AL G Reis HD Abdallah VOS Ribas RM Gontijo Filho PP (2015) Late onset sepsis in newborn babies: epidemiology and effect of a bundle to prevent central line associated bloodstream infections in the neonatal intensive care unit. Brazilian Journal of Infectious Diseases 19(1):52-57.

  • 15. Satar M Özlü F (2012) Neonatal sepsis: a continuing disease burden. The Turkish journal of pediatrics 54(5):449.

  • 16. Shah BA Padbury JF (2014) Neonatal sepsis: an old problem with new insights. Virulence 5(1):170-178.

  • 17. Shahian M Rashtian P Kalani M (2012) Unexplained neonatal jaundice as an early diagnostic sign of urinary tract infection. International Journal of Infectious Diseases 16(7):e487-e490.

  • 18. Simonsen KA Anderson-Berry AL Delair SF Davies HD (2014) Early-onset neonatal sepsis. Clinical microbiology reviews 27(1):21-47.

  • 19. Vergnano S Sharland M Kazembe P Mwansambo C Heath PT (2005) Neonatal sepsis: an international perspective. Archives of Disease in Childhood-Fetal and Neonatal Edition 90(3):F220-FF224.

  • 20. Whitehead MW Hainsworth I Kingham JGC (2001) The causes of obvious jaundice in South West Wales: perceptions versus reality. Gut 48(3):409-413.

  • 21. Youssef D Abd-Elrahman H Shehab MM Abd-Elrheem M (2015) Incidence of acute kidney injury in the neonatal intensive care unit. Saudi journal of kidney diseases and transplantation 26(1):67.

  • 22. Zhou B Liu X Wu JB Jin B Zhang YY (2016) Clinical and microbiological profile of babies born with risk of neonatal sepsis. Experimental and therapeutic medicine 12(6): 621-3625.

Journal information
All Time Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 51 51 11
PDF Downloads 34 34 7