Multidrug resistance gene 1 polymorphisms in pediatric patients with leukemia at a national referral hospital in Indonesia
Article Category: Brief communication (Original)
Published Online: Jan 31, 2017
Page range: 625 - 630
DOI: https://doi.org/10.5372/1905-7415.0905.432
Keywords
© 2015 Rina Mutiara, Bernadius Agustinus, Christian Badia Sitompul, Amarila Malik, Djajadiman Gatot, Frans D. Suyatna
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Background
Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in the pediatric population. From 25% to 30% of patients with ALL will have a relapse that leads to death when they are teenagers. At Cipto Mangunkusumo Hospital, 40% of 126 pediatric patients with ALL relapsed from 2005 to 2011. A multiple variant of multidrug resistance gene 1 (
Objectives
To identify the profile of
Methods
We collected data from 44 patients with ALL who attended Cipto Mangunkusumo Hospital between January and June 2014. We investigated a silent C3435T polymorphism in
Results
There were 32 male and 12 female patient participants in this study. Eighteen patients were 1–3 years old and 26 were over 3 years. The mean age at 1–3 years was 2.4 ± 0.86, and over 3 years it was 6.3 ± 2.67 years. There were 27 patients with ALL in the standard risk group and 17 in the high risk group. We determined that the 25 samples from patients with ALL in the standard risk group were not digestible (allele T) and the 6 samples from patients with ALL in the high risk group were digestible (allele C).
Conclusions
The prevalence of the T allele was higher than that of the C allele in pediatric Indonesian patients with ALL.