Status of circulating bone turnover markers in elderly osteoporosis/osteopenia patients in comparison with healthy subjects
Article Category: Original article
Published Online: Sep 10, 2020
Page range: 97 - 106
DOI: https://doi.org/10.1515/abm-2020-0015
Keywords
© 2020 Sadra Samavarchi Tehrani et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Background
In the aging individuals, osteoporosis is a major health problem. Due to the various limitations of dual X-ray absorptiometry (DEXA) for diagnosis osteoporosis, serum-based biochemical markers have been suggested for the discrimination between the patients and healthy subjects.
Objective
To investigate the serum levels of bone turnover markers in elderly osteoporosis patients.
Methods
The serum samples from elderly subjects (osteoporosis (n = 28), osteopenia (n = 28), and healthy ones (n = 28) were collected from Amirkola Health and Ageing Project study. Furthermore, serum levels of bone formation and bone resorption markers as well as estrogen and progesterone were measured by enzyme-linked immunosorbent assay. Kruskal–Wallis test and receiver operating characteristic curve analysis were used for statistical analysis using SPSS.
Results
Levels of bone alkaline phosphatase (B-ALP) and procollagen type I N-terminal propeptide (PINP) differed between groups (
Conclusion
In conditions in which we are not able to assess the bone mineral density by DEXA, analysis of the B-ALP and PINP levels may be a helpful tool.