Incretin levels in patients with hypothyroidism and the evaluation of incretin levels alterations with treatment
Article Category: Original article
Published Online: Dec 19, 2019
Page range: 3 - 9
DOI: https://doi.org/10.1515/abm-2019-0033
Keywords
© 2019 Serkan Alemdar et al., published by Sciendo
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.
Background
Incretin hormones may influence the effects of thyroid hormones on insulin secretion, insulin resistance, and glucose metabolism. Thyroid hormones regulate insulin secretion, and the risk of diabetes was found to be associated with thyroid hormones.
Objectives
To determine whether incretin hormones influence the effects of thyroid hormones on insulin resistance and glucose metabolism.
Methods
A total of 26 patients were included in 2 groups consisting of 13 patients with hypothyroidism and 13 healthy controls. Levels of glucose, insulin, glucagon-like peptide 1 (GLP-1), and gastric inhibitory polypeptide (GIP) levels were measured in 0, 30, 60, 90, and 120th min during the oral glucose tolerance test in the control group and before and after thyroxine treatment in the hypothyroid group.
Results
In the hypothyroid group, waist circumference decreased after the euthyroid state was achieved (
Conclusion
In patients with hypothyroidism, the incretin hormones, especially the peak response of the incretin system, are significantly affected. Significant changes were observed in the incretin system by correcting hypothyroidism.