Association of  and  polymorphisms with major depressive disorder in a Thai population

Major depressive disorder (MDD) is a common psychiatric disorder with high prevalence and high risk of suicide. Genetic variation of glutamate transporters may associate with MDD and suicide attempt.

Objectives

To evaluate polymorphisms of excitatory amino acid transporter 2 gene (SLC1A2; rs752949, rs1885343, rs4755404, and rs4354668) and vesicular glutamate transporter 1 gene (SLC17A7; rs1043558, rs2946848, and rs11669017) in patients with MDD with and without suicide attempt, and determine the association of these polymorphisms with age of onset and severity of MDD.

Methods

DNA was extracted from blood taken from patients with MDD (n = 100; including nonsuicidal [n = 50] and suicidal [n = 50] subgroups) and controls (n = 100). Genotyping was conducted using TaqMan single-nucleotide polymorphism (SNP) genotyping.

Results

We found a significant difference in SLC17A7 rs2946848 genotype distribution between patients in the MDD and control groups (P = 0.016). Moreover, significant differences in SLC1A2 rs752949 (P = 0.022) and SLC17A7 rs2946848 (P = 0.026) genotype distributions were observed between patients in the nonsuicidal MDD and suicidal MDD groups. SLC1A2 rs1885343 A allele carriers showed significantly lower age of onset than GG genotype (P = 0.049). Furthermore, the severity of MDD indicated by the Hamilton Depression Rating Scale (HDRS) score of G allele carriers of SLC1A2 rs4755404 was significantly greater than the CC genotype (P = 0.013).

Conclusions

Polymorphisms of SLC1A2 and SLC17A7 may contribute to the risk of MDD and/or suicide attempt. An association of an SLC1A2 polymorphism with the severity of MDD was apparent.

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Language:: English

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Association of SLC1A2 and SLC17A7 polymorphisms with major depressive disorder in a Thai population

Article Category: Brief communication (original)

Published Online: Sep 20, 2019

Page range: 131 - 138

DOI: https://doi.org/10.1515/abm-2019-0012

Keywordsexcitatory amino acid transporter 2, gene, major depressive disorder, single-nucleotide polymorphisms, suicide, attempted, vesicular glutamate transporter 1

© 2018 B. Thaweethee et al., published by Sciendo

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Background

Objectives

Methods

Results

Conclusions

Keywords
excitatory amino acid transporter 2, gene, major depressive disorder, single-nucleotide polymorphisms, suicide, attempted, vesicular glutamate transporter 1