Frequency of hepatitis B envelope antigen-negative chronic hepatitis B virus infection in untreated patients from three cities in Pakistan
Article Category: Brief communication (Original)
Published Online: Aug 31, 2017
Page range: 73 - 79
DOI: https://doi.org/10.5372/1905-7415.1101.541
Keywords
© 2017 Israr Ahmad, Kafeel Ahmad, Ijazul HaqueTaseer, Waqaruddin Ahmad, Javed Iqbal Farooqi, Obaid Ullah
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.
Background
Hepatitis B envelope antigen (HBeAg)-negative chronic hepatitis B virus (CHB) infection is a clinical entity refractory to treatment and has implications for disease outcome.
Objectives
To determine the frequency of HBeAg-negative CHB in untreated hepatitis B surface antigen (HBsAg)-positive patients.
Methods
We conducted this cross-sectional study of untreated HBsAg-positive patients from 3 cities in Pakistan for more than 6 months.
Results
Of495 patients, 276 (47.7%) had detectable hepatitis B virus (HBV) DNA (mean 5.3 ± 1.96 log10 copies/mL), 81 (16.4%) were HBeAg positive and 414 (83.6%) were HBeAg negative. All 81 (100%) HBeAg-positive patients had detectable HBV DNA. Frequency of HBeAg-negative CHB infection was 155 (31.3%) among HBsAg-positive patients. One hundred and sixteen (74.8%) of the HBeAg-negative patients with CHB infection were in the age range of 15–35 years.
Conclusions
HBeAg-negative patients constitute a considerable proportion of patients with CHB infection. HBsAg-positive patients, especially with younger age, should be thoroughly investigated for this entity to avoid the devastating long-term complications of this disease.