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Abdel-Rahman El-Gazzar, Hoda Hussein and Hend Hafez

Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity

5-Methyl-6-phenyl-2-thioxothieno[2,3-d]pyrimidone derivative (2) reacted with hydrazonoyl chloride derivatives to afford triazolothienopyrimidones 4a-f. Also, acetone-1-(2-amino-5-isopropyl-thiophene-3-carbonitrile) (3) reacted with functional and bifunctional groups to yield the corresponding compounds 5-11. The new products showed anti-inflammatory, analgesic, and ulcerogenic activities comparable to that of indomethacin and acetylsalicylic acid, respectively.

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Hend N. Hafez, Abdel-Rhman B. A. El-Gazzar and Magdi E. A. Zaki

. Raghuram, R. P. Shanthan, R. K. Subramanian, S. Meena and K. Madhavi, Synthesis and adenosine receptor binding studies of some novel tri-azolothieno-pyrimidines, Eur. J. Med. Chem. 43 (2008) 614-620; DOI: 10.1016/j.ejmech.2007.05.001. 19. K. A. Chakraborti, B. Gopalakrishnan, M. E. Sobhia and M. Alpeshkumar, 3D-QSAR studies on thieno[3,2-d]pyrimidines as phosphodiesterase IV inhibitors, Bioorg. Med. Chem. Lett. 13 (2003) 1403-1408; DOI: 10.1016/S0960-894X(03)00172-0. 20. M. I. Crespo, L. Pages, A. Vega, V. Segarra, M. Lopez, T. Domenech