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Jelena Stefanovic Neskovic, Andjelka Ristic, Milan Petronijevic, Branimir Neskovic and Ognjen Gudelj

References 1. M. Cutolo at al. 2004. Nailfold capillaroscopic patterns and serum antibodies in systemic sclerosis.Rheumathology; 43:719-726 2. Almeida C, Almeida I, Vasconcelos C. 2015 Dec. Quality of life in systemic sclerosis. Autoimmun Rev.;14(12):1087-96. doi: 10.1016/j.autrev.2015.07.012. Epub 2015 Jul 23. 3. Plazak W, Zabinska-Plazak E, Wojas Pelc A, Podolec P, Olszowka M, Tracz W, et al. 2002. Heart structure and function in systemic sclerosis. Eur J Dermatol; 12:257-62. 4. D’Andrea A, D

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E. Krasimirova and D. Kyurkchiev

REFERENCES 1. Varga, J. et D. Abraham. Systemic sclerosis: a prototypic multisystem fibrotic disorder. – J Clin Invest, 117, 2007, № 3, 557-67. 2. Mayes M. et S. Assassi. Classification and epidemiology of scleroderma. – In: Rheumatology. 6th ed. Hochberg, M. C., A. J. Silman, J. S. Smolen, M. E. Weinblatt et M. H. Weisman (Ed.). Philadelphia, Mosby, ELSEVIER; 2015, 1153-1158. 3. Steen, V. D. Autoantibodies in systemic sclerosis. – Semin Arthritis Rheum, 35, 2005, N 1, 35-42. 4. Chan, H. L., Y. S. Lee, H. S. Hong, et al. Anticentromere

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Paul Bălănescu, Eugenia Bălănescu and Anca Bălănescu

patients with systemic sclerosis . Arthritis Rheum. 2000; 43 (11):2455-63. 11. MURATA M, FUJIMOTO M, MATSUSHITA T, HAMAGUCHI Y, HASEGAWA M, TAKEHARA K, et al. Clinical association of serum interleukin-17 levels in systemic sclerosis: is systemic sclerosis a Th17 disease? J Dermatol Sci. 2008; 50 (3):240-2. 12. GOURH P, ARNETT FC, ASSASSI S, TAN FK, HUANG M, DIEKMAN L, et al. Plasma cytokine profiles in systemic sclerosis: associations with autoantibody subsets and clinical manifestations . Arthritis Res Ther, 2009; 11 (5):R147. 13. HIGGS BW, ZHU

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Jelena Stefanović Nešković, Anđelka Ristić, Milan Petronijević, Aleksandra Zeljković, Aleksandra Grdinić, Ognjen Gudelj, Branka Đurović and Branimir Nešković

References 1. Cutolo M, et al. Nailfold capillaroscopic patterns and serum antibodies in systemic sclerosis. Rheumatology 2004; 43: 719–26. 2. Lambova S. Cardiac manifestations in systemic sclerosis. World J Cardiol 2014; 6(9): 993–1005. 3. Plazak W, Zabinska-Plazak E, Wojas Pelc A, Podolec P, Olszowka M, Tracz W, et al. Heart structure and function in systemic sclerosis. Eur J Dermatol 2002; 12: 257–62. 4. D’Andrea A, D’Alto M, Di Maio M, Vettori S, Benjamin N, Cocchia R, Argiento P, Romeo E, Di Marco G, Russo MG, Valentini G, Calabrò R

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Ana Maria Daraban, Roxana Enache, L. Predescu, P. Platon, T. Constantinescu, Carina Mihai, I.M. Coman, Carmen Ginghină and Ruxandra Jurcuţ

2000; 69 : 177–179. 9. NUNES H, HUMBERT M, CAPRON F, et al . Pulmonary hypertension associated with sarcoidosis: mechanisms, hemodynamics and prognosis . Thorax 2006; 61 : 68–74. 31 10. FARTOUKH M, HUMBERT M, CAPRON F, et al . Severe pulmonary hypertension in histiocytosis X . Am J Respir Crit Care Med 2000; 161 : 216–223. 11. KHANNA D. Diagnosis and treatment of systemic and localized scleroderma. Expert Rev. Dermatol. 2011; 6 (3):287–302. 12. CHAISSON NF, HASSOUN PM. Systemic Sclerosis-Associated Pulmonary Arterial Hypertension

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Paul Bălănescu, Anca Lădaru, Eugenia Bălănescu, Adriana Nicolau, C. Băicuş and Gh.A. Dan

References 1. BREMBILLA NC, CHIZZOLINI C. T cell abnormalities in systemic sclerosis with a focus on Th17 cells. Eur Cytokine Netw. 2012; 23(4):128-39. 2. ZHU J, PAUL WE. CD4 T cells: fates, functions, and faults. Blood. 2008; 112(5):1557-69. 3. PAVLOVIC V, DIMIC A, MILENKOVIC S, KRTINIC D. Serum levels of IL-17, IL-4, and INFγ in Serbian patients with early rheumatoid arthritis. J Res Med Sci. 2014; 19(1):18-22. 4. BĂLĂNESCU P, BĂLĂNESCU E, TĂNĂSESCU C, NICOLAU A, TĂNĂSESCU R, GRANCEA C, VAGU C

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Winnie Wan-Yin Yeung and Chak-Sing Lau

synergistic effect. 3.3 MSCT in Systemic Sclerosis (SSc) The main mechanism of MSCT in systemic sclerosis (SSc) is the inhibition of proliferation of T lymphocytes and B lymphocytes. BM-derived MSCs from patients with SSc appeared similar to those healthy individuals in their phenotype and capacity to differentiate into adipogenic and osteogenic lineages and similar immunosuppressive properties. However, patients with SSc have a diminished capacity to differentiate into endothelial progenitor cells and to contribute to vasculogenesis. In other words, theoretically

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I. Lazúrová, J. Rovenský, R. Imrich, S. Blažíčková, Z. Lazúrová and J. Payer

JA, Fritz VU. Polymyositis associated with Klinefelter‘s syndrome. SAMJ1999, 89: 420-421. [30] Murakami, M Kishino B, Fushimi H, Sakata Y, Matsuyuki Y. The first report of Klinefelter‘s syndrome associated with polymyositis. Nippon Naika Cakkai Zashiu. 1988, 7: 530-535. [31] Nowlin NS, Zwillich SH, Brick JE, Carlson HE. Male hypogonadism and scleroderma, Rheumatol. 1985, 12: 605-606. [32] O‘Donoghue DJ: Klinefelter‘s syndrome associated with systemic sclerosis. Postgrad Med. J.1982, 58: 575-576. [33

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Nóra Raț, Diana Opincariu, Ciprian Blendea, Roxana Cucuruzac, Pirvu Mirela, Monica Chitu, Imre Benedek and Theodora Benedek

Fail . 2005;7:1011-1016. 11. Hoeper MM. Pulmonary hypertension in collagen vascular disease. Eur Respir J . 2002;19:571-576. 12. Mukerjee D, St George D, Coleiro B, et al. Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis . 2003;62:1088-1093. 13. Fisher MR, Mathai SC, Champion HC, et al. Clinical differences between idiopathic and scleroderma-related pulmonary hypertension. Arthritis &Rheumatology . 2006;54:3043-3050. 14. Benedek T, Opincariu D, Rat N

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Eleni-Marina Kalogirou and Alexandra Sklavounou

Epidermolysis Bullosa With Severe Symptoms. J Oral Implantol, 2016;42:498-505. 16. Leung WK, Chu CH, Mok MY, Yeung KW, Ng SK. Periodontal status of adults with systemic sclerosis: casecontrol study. J Periodontol, 2011;82:1140-1145. 17. Aboushelib MN, Elsafi MH. Clinical Management Protocol for Dental Implants Inserted in Patients with Active Lichen Planus. J Prosthodont, 2017;26:29-33. 18. Czerninski R, Eliezer M, Wilensky A, Soskolne A. Oral lichen planus and dental implants--a retrospective study. Clin Implant Dent Relat Res