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Cécilia Bognon-Küss, Bohang Chen and Charles T. Wolfe

-Enlightenment Life science, 1800–2010 . Dordrecht: Springer. O’Malley MA, Powell A, Davies JF, and Calvert J, 2008, Knowledge-making distinctions in synthetic biology, BioEssays , 30(1), 57–65. Pascal, B., 1964–1992, OEuvres complétes , Texte établi, présenté et annoté par Jean Mesnard, édition du Tricentenaire, Paris: Desclée de Brouwer, Bibliothèque européenne. Peterson, E.L., 2010, Holism and Evolution in Biology and Anthropology: the Challenge of Gregory Bateson and C. H. Waddington to Biological Orthodoxy, 1924–1980. PhD Dissertation, University of Notre

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Thierry Magnin

Abstract

Starting from research on biotechnology and its applications to living organisms, this paper presents the key features of modern-day synthetic biology, as well as its main ethical implications. The analysis of the paradox of the concept of robustness in the creation of microorganisms through synthetic biology leads us to address the topic of vulnerability, applied to man, but also to all other living beings. The concept of “enhanced human being” will strengthen the link between complexity and vulnerability as inherent features of living beings. Reflecting upon the importance of considering vulnerability applied to man’s three-fold dimensions - physical, psycho-social and spiritual - and their interaction with their environment, we will define a type of anthropology which may constitute the basis of the study on the ethical implications of synthetic biology. This will lead to present the purpose of an ethical limit to the temptation of « allmightiness », which the concept of enhanced human being could entail, and vulnerability as a defining feature of all living beings.

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Vibrant Architecture

Matter as a CoDesigner of Living Structures

Rachel Armstrong

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Ting Shan Yao, Xiao Feng Zhu, Jin Hee Jung and Yuan Hu Xuan

. Overexpression of DWARF4 in the brassinosteroid biosynthetic pathway results in increased vegetative growth and seed yield in Arabidopsis . Plant Journal 26: 573–582. C louse SD, and S asse JM. 1998. BRASSINOSTEROIDS: Essential regulators of plant growth and development. Annual Review of Plant Physiology and Plant Molecular Biology 49: 427–451. E bine K, U emura T, N akano A, and U eda T. 2012. Flowering time modulation by a vacuolar SNARE via FLOWERING LOCUS C in Arabidopsis thaliana . Plos One 7 : e42239. E bine K, O katani Y, U emura T, G

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Jadranka Dunđerski and Gordana Matić

Glucocorticoid Receptor in Health and Disease

Glucocorticoid hormones are essential for life, have a vital place in the treatment of inflammatory and autoimmune diseases and are increasingly implicated in the pathogenesis of a number of common disorders. Their action is mediated by an intracellular receptor protein, the glucocorticoid receptor (GR), functioning as a ligand-inducible transcription factor. Multiple synthetic glucocorticoids are used as potent antiinflammatory and immunosuppressive agents, but their therapeutic usefulness is limited by a wide range and severity of side-effects. One of the most important pharmaceutical goals has been to design steroidal and non-steroidal GR ligands with profound therapeutic efficacy and reduced unwanted effects. The therapeutic benefit of glucocorticoid agonists is frequently compromised by resistance to glucocorticoids, which may depend on: access of the hormones to target cells, steroid metabolism, expression level and isoform composition of the GR protein, mutations and polymorphisms in the GR gene and association of the receptor with chaperone proteins. The major breakthrough into the critical role of glucocorticoid signaling in the maintenance of homeostasis and pathogenesis of diseases, as well as into the molecular mechanisms underlying the therapeutic usefulness of antiinflammatory drugs acting through the GR is expected to result from the current progress in large-scale gene expression profiling technologies and computational biology.

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Radomir Ščurek, Marek Hütter and Ondřej Los

References ALBERTS, Bruce. 1998. Essential Cell Biology: An Introduction to Molecular Cell Biology. Ústí nad Labem: Espero, 1998. ISBN 80-902906-0-4. (in Czech) Forensic marking. 2015. [online]. 2015 [cited: 2015-01-08]. Available from: https://www.forenzniznaceni.cz/inpage/nejcastejsi-otazky/ (in Czech) KONÍČEK, Tomáš. 2011. New possibilities in forensic property marking. Ministerstvo vnitra ČR [online]. 2011 [cit. 2015-01-08]. Available from: http

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Andrew Schumann

Company, 2010. [4] A. Lindenmayer, “Mathematical models for cellular interaction in development. parts I and II,” Journal of Theoretical Biology, 18, 1968, pp. 280–299; 300–315. [5] J. Łukasiewicz, Aristotle’s Syllogistic From the Standpoint of Modern Formal Logic. Oxford Clarendon Press, 2nd edition, 1957. [6] Y. Matveyev, “Symbolic computation and digital philosophy in early Ashkenazic Kabbalah,” [in:] Schumann, A. (ed.), Judaic Logic . Gorgias Press, 2010, 245–256. [7] K. Niklas, Computer Simulated Plant Evolution. Scientific American, 1985

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Simona Nicoleta Stan, Amalia-Gianina Străteanu, George Cosmin Colang and Marian Nicolae

.pdf *** https://www.croptrust.org/in-the-news/cultures-agro-biodiversity-food-security/ *** National Science Advisory Board for Biosecurity (NSABB). (2010). Addressing Biosecurity Concerns Related to Synthetic Biology. Available at: http://oba.od.nih.gov/biosecurity/pdf/ NSABB%20SynBio%20DRAFT%20Report-FINAL%20(2)_6-7-10.pdf. *** https://www.nature.com/scitable/knowledge/library/food-safety-and-food-security-68168348

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Maria Pobożniak, Dominika Grabowska and Marta Olczyk

oil compounds for thrips control – a review. In Natural Products Communication, vol. 3, pp. 1171–1182. ISSN 1934-578X. KOSCHIER, E. H. – Sedy, K. A. – Novak, J. 2002. Influence of plant volatiles on feeding damage caused by the onion thrips Thrips tabaci . In Crop Protection, vol. 21, no. 5, pp. 419–425. ISSN 0261-2194. LEŚNIAK, M. – POBOŻNIAK, M. – PNIAK, M. 2013. The influence of orange oil and orange synthetic aroma on Tetranychus urticae (Koch.), Aphis phomi (Deg.) and Eriosoma lanigerum (Hasm.). In Episteme, vol. 22, pp. 101–107. ISSN 1895

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Kazimierz Jankowski, Roman Kolczarek, Jolanta Jankowska, Jacek Sosnowski, Beata Wiśniewska-Kadżajan, Milena Truba and Anna Kaczorek

other synthetic growth inhibitors and selected growth modifying substances., (Ed. Jankiewicz L.S) controls plant growth and development, Oxford University Press, 108-123. KOZIARA W., CZAJKA M., SOBIECH S. 1993. Effect of irrigation, nitrogen fertilization and the use of BERC CCC on yield of spring triticale., Biology and cultivation of triticale, Międzyzdroje, 31. PAWLONKA Z., SKRZYCZYŃSKA J. 2004. The effect of selected factors agrotechnical and weather conditions on the weeding of winter triticale. Annales UMCS, Sec. E, 59, 3, 1037