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Molecular Pathogenesis of Liver Steatosis Induced by Hepatitis C Virus

References 1. Chang ML, Yeh HC, Tsou YK, Wang CJ, Cheng HY, Sung CM, et al. HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration. Obesity (Silver Spring) 2012; doi: 10.1038/ oby.2012.45. 2. Sato S, Fukasawa M, Yamakawa Y, Natsume T, Suzuki T, Shoji I, et al. Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein. J Biochem 2006;139:921-930. 3. Congiu M, Ryan MC, Desmond PV. No

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Hepatocyte steatosis increases the expression of adhesion molecules in endothelial cells

: potential implications for inflammation and plaque instability. Circulation. 2000; 101: 1372-8. 13. Mazzone GL, Rigato I, Ostrow JD, Bossi F, Bortoluzzi A, Sukowati CH, et al. Bilirubin inhibits the TNFalpharelated induction of three endothelial adhesion molecules. Biochem Biophys Res Commun. 2009; 386: 338-44. 14. Jin X, Yang YD, Chen K, Lv ZY, Zheng L, Liu YP, et al. HDMCP uncouples yeast mitochondrial respiration and alleviates steatosis in L02 and hepG2 cells by decreasing ATP and H2O2 levels: a novel mechanism for NAFLD. J Hepatol

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Distribution of hepatitis C virus genotypes, hepatic steatosis and their correlation with clinical and virological factors in Pakistan

. Hepatology. 1992; 16:293-9. 6. Kanai K, Kako M, Okamoto H. HCV genotypes in chronic hepatitis C virus and response to interferon. Lancet. 1992; 339:1543. 7. Shah H.A, Jafri W, Malik I, Prescott L, Simmonds P. Hepatitis C virus (HCV) genotypes and chronic liver disease in Pakistan. J Gastroenterol Hepatol. 1997; 12: 758-61. 8. Szanto P, Grigorescu M, Dumitru I, Serban A. Steatosis in hepatitis C virus infection. Response to anti-viral therapy. J Gastrointestin Liver Dis. 2006; 15:117-24 9. Marzouk D, Sass J

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The Relationship between Hepatic Steatosis, inflammation and insulin Resistance in type 2 Diabetes with Metabolic Imbalance

, Nascimbeni F, Pais R, et al. Performance And Limitations Of Steatosis Biomarkers In Patients With Nonalcoholic Fatty Liver Disease. Alimentary Pharmacology & Therapeutics, 2014; 40(10):1209-1222. DOI:10.1111/apt.12963. 5. Lonardo A, Nascimbeni F, Maurantonio M, et al. Nonalcoholic Fatty Liver Disease: Evolving Paradigms. World Journal Of Gastroenterology, 2017; 23(36):6571-6592. DOI:10.3748/wjg.v23.i36.6571. 6. Kitade H, Chen G, Ni Y and Ota T. Nonalcoholic Fatty Liver Disease And Insulin Resistance: New Insights And Potential New Treatments. Nutrients, 2017; 9

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Diethanolamine-Induced Hepatic Steatosis in Mice and Its Amelioration by Curcumin

.; Persing, R.L. Toxicity of diethanolamine. 2. Drinking water and topical application exposures in B6C3F1 mice. J. Appl. Toxicol . 1994 , 14(1) , 11-19. 17. Sharma, S.; Sharma, C.; Pracheta, Paliwal, R.; Sharma, S. Protective effect of Curcuma longa and curcumin on aflatoxin B1 induced hepatotoxicity in Swiss albino mice. Asian J. Pharm. Health Sci. 2011 , 1(3) , 116-122. 18. Jin, G.; Yongxian, Z.; Daqian, X.; Zilong, Z.; Yuxue, Z.; Yi, P.; Peijuan, C.; Zhenzhen, W.; Yan, C. Ethanol-induced hepatic steatosis is modulated by glycogen level in the liver

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Noninvasive Markers of Improvement of Liver Steatosis Achieved by Weight Reduction in Patients with Nonalcoholic Fatty Liver Disease

of steatohepatitis in mice. J Inflamm (Lond). 2011; 8:8. 9. PARK SH, KIM BI, KIM SH, KIM HJ, PARK DI, CHO YK, SUNG IK, SOHN CI, KIM H, KEUM DK, KIM HD, PARK JH, KANG JH, JEON WK. Body fat distribution and insulin resistance: beyond obesity in nonalcoholic fatty liver disease among overweight men. J Am Coll Nutr 2007; 26:321-326. 10. PARK BJ, KIM YJ, KIM DH, KIM W, JUNG YJ, YOON JH, KIM CY, CHO YM, KIM SH, LEE KB, JANG JJ, LEE HS. Visceral adipose tissue area is an independent risk factor for hepatic steatosis. J Gastroenterol Hepatol

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ST2 Deficiency Ameliorates High Fat Diet-Induced Liver Steatosis In BALB/c Mice

GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Am J Clin Nutr. 2014;99(4):869-74. 8. Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest. 2008;118(3):829-38. 9. Ferre P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes, obesity & metabolism. 2010;12 Suppl 2:83-92. 10. Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A

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The Incidence Of Hepatic Steatosis Recently Found In Patients With Diabetes Mellitus Type 2 Newly Discovered


The nonalcoholic hepatic steatos is represents one of the most frequent disorders in patients with diabetes mellitus type 2. The obesity and especially the abdominal adipose tissue distribution represent factors of higher risk for nonalcoholic hepatic steatosis. The echographic examination and FirboScan are very important in identification of this disorder. The study consisted in analysis of the clinical and paraclinical results in order to identify the SHNA (The nonalcoholic hepatic steatosis) incidence. It must be mentioned the fact that the absence of the abdominal obesity and increased transaminases do not exclude SHNA(The nonalcoholic hepatic steatosis).

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Insulin Resistance in Liver Diseases

;82(6):2606-12. Negro F, Sanyal AJ. Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. Liver Int. 2009; Suppl 2:26-37. Koike K. Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection. J Gastroenterol. 2009;44(Suppl 19):82-8. Del Campo JA, Romero-Gómez M. Steatosis and insulin resistance in hepatitis C: a way out for the virus? World J Gastroenterol. 2009;15(40):5014-9. Miquilena-Colina ME, Cabello EL, Sanchez-Campos S, et al. Hepatic fatty acid

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Pathological Alterations in Hepatocytes of Dairy Cows With a Tendency to Emaciation and Fattening

. Li, M., Song, J., Mirkov, S., Xiao, S. Y., Hart, J., Liu, W., 2011: Comparing morphometric, biochemical and visual measurements of macrovesicular steatosis of liver. Hum. Pathol., 42, 356-360. 18. Mak, K. M., Kwong, A. J., Chu, E., Hoo, N. M., 2012: Hepatic steatosis, fibrosis and cancer in elderly cadavers. Anat. Rec., 295, 40-50. 19. Makovicky, P., Dudova, M., Tumova, E., Rajmon, R., Vodkova, Z., 2011: Experimental study of non-alcoholic fatty liver disease (NAFLD) on a model of starving chickens: is generalization of steatosis

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