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Jun Cheng, Min Li, Ping Gao, Jin-ling Dong and Qi Wang

References 1. Chang ML, Yeh HC, Tsou YK, Wang CJ, Cheng HY, Sung CM, et al. HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration. Obesity (Silver Spring) 2012; doi: 10.1038/ oby.2012.45. 2. Sato S, Fukasawa M, Yamakawa Y, Natsume T, Suzuki T, Shoji I, et al. Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein. J Biochem 2006;139:921-930. 3. Congiu M, Ryan MC, Desmond PV. No

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Gang Lin, Xiaoyan Duan, Xiaobo Cai, Liyan Tian, Zhengjie Xu and Jiangao Fan

: potential implications for inflammation and plaque instability. Circulation. 2000; 101: 1372-8. 13. Mazzone GL, Rigato I, Ostrow JD, Bossi F, Bortoluzzi A, Sukowati CH, et al. Bilirubin inhibits the TNFalpharelated induction of three endothelial adhesion molecules. Biochem Biophys Res Commun. 2009; 386: 338-44. 14. Jin X, Yang YD, Chen K, Lv ZY, Zheng L, Liu YP, et al. HDMCP uncouples yeast mitochondrial respiration and alleviates steatosis in L02 and hepG2 cells by decreasing ATP and H2O2 levels: a novel mechanism for NAFLD. J Hepatol

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Sher Zaman Safi, Yasmin Badshah, Yasir Waheed, Kaneez Fatima, Sadia Tahir, Alamgir Shinwari and Ishtiaq Qadri

. Hepatology. 1992; 16:293-9. 6. Kanai K, Kako M, Okamoto H. HCV genotypes in chronic hepatitis C virus and response to interferon. Lancet. 1992; 339:1543. 7. Shah H.A, Jafri W, Malik I, Prescott L, Simmonds P. Hepatitis C virus (HCV) genotypes and chronic liver disease in Pakistan. J Gastroenterol Hepatol. 1997; 12: 758-61. 8. Szanto P, Grigorescu M, Dumitru I, Serban A. Steatosis in hepatitis C virus infection. Response to anti-viral therapy. J Gastrointestin Liver Dis. 2006; 15:117-24 9. Marzouk D, Sass J

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Ionel Copaci, Ioana Lupescu, Elena Caceaune, Grethi Chiriac and G. Ismail

of steatohepatitis in mice. J Inflamm (Lond). 2011; 8:8. 9. PARK SH, KIM BI, KIM SH, KIM HJ, PARK DI, CHO YK, SUNG IK, SOHN CI, KIM H, KEUM DK, KIM HD, PARK JH, KANG JH, JEON WK. Body fat distribution and insulin resistance: beyond obesity in nonalcoholic fatty liver disease among overweight men. J Am Coll Nutr 2007; 26:321-326. 10. PARK BJ, KIM YJ, KIM DH, KIM W, JUNG YJ, YOON JH, KIM CY, CHO YM, KIM SH, LEE KB, JANG JJ, LEE HS. Visceral adipose tissue area is an independent risk factor for hepatic steatosis. J Gastroenterol Hepatol

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Nemanja Jovicic, Ilija Jeftic, Marina Miletic Kovacevic, Irena Tanaskovic, Nebojsa Arsenijevic, Miodrag L. Lukic and Nada Pejnovic

GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals. Am J Clin Nutr. 2014;99(4):869-74. 8. Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest. 2008;118(3):829-38. 9. Ferre P, Foufelle F. Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes, obesity & metabolism. 2010;12 Suppl 2:83-92. 10. Negrin KA, Roth Flach RJ, DiStefano MT, Matevossian A

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Cristina Cojocaru and E. Circo


The nonalcoholic hepatic steatos is represents one of the most frequent disorders in patients with diabetes mellitus type 2. The obesity and especially the abdominal adipose tissue distribution represent factors of higher risk for nonalcoholic hepatic steatosis. The echographic examination and FirboScan are very important in identification of this disorder. The study consisted in analysis of the clinical and paraclinical results in order to identify the SHNA (The nonalcoholic hepatic steatosis) incidence. It must be mentioned the fact that the absence of the abdominal obesity and increased transaminases do not exclude SHNA(The nonalcoholic hepatic steatosis).

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M Irshad, Khushboo Irshad and Prashant Nag

;82(6):2606-12. Negro F, Sanyal AJ. Hepatitis C virus, steatosis and lipid abnormalities: clinical and pathogenic data. Liver Int. 2009; Suppl 2:26-37. Koike K. Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection. J Gastroenterol. 2009;44(Suppl 19):82-8. Del Campo JA, Romero-Gómez M. Steatosis and insulin resistance in hepatitis C: a way out for the virus? World J Gastroenterol. 2009;15(40):5014-9. Miquilena-Colina ME, Cabello EL, Sanchez-Campos S, et al. Hepatic fatty acid

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J. Pivko, P. Makovický, A. Makarevich, A. Sirotkin, P. Makovický and E. Kubovičová

. Li, M., Song, J., Mirkov, S., Xiao, S. Y., Hart, J., Liu, W., 2011: Comparing morphometric, biochemical and visual measurements of macrovesicular steatosis of liver. Hum. Pathol., 42, 356-360. 18. Mak, K. M., Kwong, A. J., Chu, E., Hoo, N. M., 2012: Hepatic steatosis, fibrosis and cancer in elderly cadavers. Anat. Rec., 295, 40-50. 19. Makovicky, P., Dudova, M., Tumova, E., Rajmon, R., Vodkova, Z., 2011: Experimental study of non-alcoholic fatty liver disease (NAFLD) on a model of starving chickens: is generalization of steatosis

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Jolanta Zalejska–Fiolka, Aleksandra Kasperczyk, Sławomir Kasperczyk, Barbara Stawiarska-Pięta, Rafał Fiolka and Ewa Birkner

References 1. Bandsma R.H., Wiegman C.H., Herling A.W., Burger H.J., ter Harmsel A., Meijer A.J., Romjin J.A., Reijngoud D.J., Kuipers F.: Acute inhibition of glucose- 6-phoshpate translocator acitvity leads to increase de novo lipogenesis and development of hepatic steatosis without VLDL production in rats. Diabetes 2001, 50, 2591-2597. 2. Champe P.C., Harvey R.A.: Biochemistry, Philadelphia, USA, 1994. 3. Choe E., Min D.B.: Chemistry of deep-fat frying oils. J Food Sci 2007, 72 77

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Sombat Treeprasertsuk, Piyawat Komolmit and Wiriya Tanyaowalak

Ther. 2005; 22(Suppl 2):24-7. 4. Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology. 2004; 126:586-97. 5. Clouston AD, Jonsson JR, Powell EE. Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others. Clin Liver Dis. 2007; 11:173-89. 6. Yokoyama H, Hirose H, Ohgo H, Saito I. Inverse association between serum adiponectin level and transaminase