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Matej Horvat, Uros Potocnik, Katja Repnik, Rajko Kavalar, Vesna Zadnik, Stojan Potrc and Borut Stabuc

practice. 16 , 17 Single nucleotide polymorphisms (SNPs) are molecular factors that might be useful as prognostic markers in CRC. Preliminary genome wide association (GWA) study in non-caucasian population has indicated a role of SNPs in resectable CRC. 18 We hypothesized that SNPs participating in genetic risk for CRC and metastasis might prove as a prognostic factor in resectable CRC. In our study, we have selected SNPs with higher frequency in patients with either local lymph node involvement or systemic dissemination in genes participating in CRC carcinogenesis

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Akhiyan Hadi Susanto, Widodo, Mohammad Saifur Rohman, Didik Huswo Utomo and Mifetika Lukitasari

Single nucleotide polymorphisms (SNPs) are estimated to occur in 1 of every 1,000 nucleotides in the human genome [ 1 , 2 ]. Depending on where a SNP occurs, it might have various consequences at the phenotypic level. SNPs that alter the function or structure of the encoded proteins are a necessary and sufficient cause of most of the known recessively or dominantly inherited monogenic disorders. These SNPs are found in the coding regions of genes and are routinely analyzed for medical purposes [ 3 ]. SNPs in the promoter region of genes affect the

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P Noveski, S Trivodalieva, G Efremov and D Plaseska-Karanfilska

References Jobling MA, Tyler-Smith C. The human Y chromosome: an evolutionary marker comes of age. Nat Rev Genet 2003; 4(8): 598-612. Lessig R, Zoledziewska M, Fahr K, Edelmann J, Kostrzewa M, Dobosz T, Kleemann WJ. Y-SNP-genotyping—a new approach in forensic analysis. Forensic Sci Int 2005; 154(2-3): 128-136. Krausz C, Quintana-Murci L, Forti G. Y chromosome polymorphisms in medicine. Ann Med 2004; 36(8): 573-583. Y Chromosome Consortium. A nomenclature

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D.P. Berry, N. McHugh, E. Wall, K. McDermott and A.C. O’Brien

be robust, technically accurate, inexpensive, and require minimal effort by producers and breeders. Moreover, the tools should ideally be such as not to stifle collaboration in (genomic) data exchange. The exploitation of genomic technologies in animal production systems is intensifying, primarily in response to improved accuracy of prediction of true genetic merit when the genotype of an animal is incorporated into genetic evaluations ( Hayes et al ., 2009 ; Spelman et al ., 2013 ). The cost of the commonly termed single nucleotide polymorphism (SNP) chips

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Vivi Yuskianti, Fa Xin Huang, Bian Xiang Zhang and Susumu Shiraishi

References A chere , V., P. F aivre R ampant , L. E. P aques and D. P rat (2004): Chloroplast and mitochondrial molecular tests identify European x Japanese larch hybrids. Theoretical Applied Genetics 108 : 1643–1649. A itken , N., S. S mith , C. S chwarz and P. A. M orins (2004): Single nucleotide polymorphism (SNP) discovery in mammals: a targeted-gene approach. Molecular Ecology 13 : 1423–1431. B atley , J., R. M ogg , D. E dwards , H. O’S ullivan and K. J. E dwards (2003): A high-throughput SNuPE assay for genotyping SNPs in the

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Jaromír Kadlec, Božena Hosnedlová, Václav Řehout, Jindřich Čítek, Libor Večerek and Lenka Hanusová

References Amills M, Jiménez N, Villalba D, Tor M, Molina E, Cubiló D, Marcos C, Francesch A, Sanchez A, Estany J (2003): Identification of three single nucleotide polymorphisms in the Chicken - Insulin-Like Growth Factor 1 and 2 genes and their associations with growth and feeding traits. Poultry Sci 82: 1485-1493. Beccavin C, Chevalier B, Cogburn LA, Simon J, Duclos MJ (2001): Insulin-like growth factors and body growth in chickens divergently selected for high or low growth rate. J Endocrinol 168: 297

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Ramin Saravani, Elahe Esmaeilzaei, Nafiseh Noorzehi and Hamid Reza Galavi

Single Nucleotide Polymorphism in its Receptor MTNR1B Gene with Breast Cancer. Middle East J Cancer. 2015;6(1):11-20. 23. Li C, Shi Y, You L, Wang L, Chen Z-J. Association of rs10830963 and rs10830962 SNPs in the melatonin receptor (MTNR1B) gene among Han Chinese women with polycystic ovary syndrome. Mol Hum Reprod. 2011;17(3):193-8. DOI: 10.1093/molehr/gaq087 24. Xia Q, Chen Z-X, Wang Y-C, Ma Y-S, Zhang F, Che W, et al. Association between the melatonin receptor 1B gene polymorphism on the risk of type 2 diabetes, impaired glucose

Open access

J Krsteski, S Jurgec, M Pakiž, I But and U Potočnik

(rs11575934) and IL23R (rs7517847) Single Nucleotide Polymorphisms The rs2070874 ( IL4) and rs1801275 ( IL4R) SNPs were selected according to their known functional role in IL expression. Single nucleotide polymorphisms rs11575934 ( IL12RBI) , rs6887695 ( IL12B) , rs20541 ( IL13) and rs7517847 ( IL23R) were previously reported to be associated with other ULM-related immune-mediated diseases, such as inflammatory bowel disease [ 22 ], glioblastoma [ 23 ], cervical adenocarcinoma and an increased risk of tuberculosis [ 24 ]. Genotyping of IL4 (rs2070874

Open access

Gábor Mészáros

pedigrees is that they neither exist nor are accurate for many of the livestock breeds, which negates or seriously hampers any effort to assess genetic diversity. With the availability of molecular markers such as microsatellites, and more recently single nucleotide polymorphisms (SNP) and whole genome sequence data, it is possible to analyze diversity on a genomic level. The dense marker genotypes negate the necessity to have historical records, and thus, all problems associated with pedigrees. It allows a more precise assessment of relatedness accounting for Mendelian

Open access

Reza Talebi, Ahmad Ahmadi, Fazlollah Afraz, Julien Sarry, Florent Woloszyn and Stéphane Fabre

sheep breeds. Vet. Res. Commun., 35: 157-167. Kumar S., Mishra A.K., Kolte A.P., Dash S.K., Karim S.A. (2008). Screening for Booroola (Fec B) and Galway (Fec XG) mutations in Indian sheep. Small Rumin. Res., 80: 57-61. Liandris E., Kominakis A., Andreadou M., Kapeoldassi K., Chadio S., Tsiligi-anni T.H., Gazouli M., Ikonomopoulos I. (2012). Associations between single nucleotide polymorphisms of GDF9 and BMP15 genes and litter size in two dairy sheep breeds of Greece. Small Rumin. Res., 107: 16-21. Liu S.F., Jiang Y