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Mohammed Albratty, Karam Ahmed El-Sharkawy and Shamsher Alam

, anticonvulsant and antiinflammatory studies of new 1,4-dihydropyridin-4-yl-phenoxyacetohydrazones, Eur. J. Med. Chem. 70 (2013) 341-349; DOI: 10.1016/j. ejmech.2013.10. 010. 11. A. A. Napoleon, F. R. N. Khan, E. D. Jeong and E. H. Chung, Potential antitubercular agents: Hexahydro-3-phenyl indazol-2-yl-(pyridine-4-yl) methanones from antitubercular drug isoniazid and bis(substituted benzylidene) cycloalkanones, Chin. Chem. Lett. 26 (2015) 567-571; DOI: 10.1016/j.cclet.2015.01.008. 12. S. Malik, P. Ahuja, K. Sahu and S. A. Khan

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Flóra Jozefíková, Milan Mazúr, Miroslava Puchoňová and Dušan Valigura

Abstract

Three new nitrosalicylatocopper(II) complexes have been prepared and characterized. Compounds of the composition Cu(5-NSal)2(2-ampy)2 (1), Cu(5-NSal)2(2-hmpy)2 (2) and Cu(3,5-DNSal)2(2-hmpy)2 (3), where 2-ampy = (2-aminomethyl)pyridine, 2-hmpy = (2-hydroxymethyl)pyridine, 5-NSal = 5-nitrosalicylate anion and 3,5-DNSal = 3,5-dinitrosalicylate anion, were characterized by elemental analyses, EPR and IR spectroscopy. EPR spectra are consistent with the dx2-y2ground electronic state. Spectral properties have shown “classic” monodentate coordination of 5-nitrosalicylate anion. Similarly, bonding mode of the 3,5‑dinitrosalicylate anion in (3) is assumed to be unidentate via the carboxyl group, which is surprising compared with the previously studied complex, where the preferred coordination via the phenolate group anion was observed.

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Rafat Mohareb, Karam El-Sharkawy and Sherif Sherif

and molluscicidal activity of some 1,3,4-triaryl-5-chloropyrazole, pyrano[2,3-c]pyrazole, pyrazolylphthalazine and pyrano[2,3-d]thiazole derivatives, Arch. Pharm. (Weinheim) 339 (2006) 305-312; DOI: 10.1002/ardp.200500259. F. M. Abdelrazek and A. D. Fathy, A novel synthesis and molluscicidal activity of some functionally substituted pyridine, pyrido[3,2-c]pyridazine, and pyrido[3,2-c]pyridazino[2',3'-a]quinazoline derivatives, Arch. Pharm. (Weinheim) 338 (2005) 329-334; DOI: 10.1002/ardp.200400938. S. Alias, R

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Mohammed Albratty, Karam Ahmed El-Sharkawy and Hassan Ahmed Alhazmi

REFERENCES 1. N. C. Desai, H. Somani, A. Trivedi, K. Bhatt, L. Nawale, V. M. Khedkar, P. C. Jha and D. Sarkar, Synthesis, biological evaluation and molecular docking study of some novel indole and pyridine based 1,3,4-oxadiazole derivatives as potential antitubercular agents, Bioorg. Med. Chem. Lett . 26 (2016) 1776–1783; https://doi.org/10.1016/j.bmcl.2016.02.043 2. A. G. Banerjee, N. Das, S. A. Shengule, R. S. Srivastava and S. K. Shrivastava, Synthesis, characterization, evaluation and molecular dynamics studies of 5,6-diphenyl-1,2,4-triazin-3(2 H

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Mostafa M. Ghorab, Mansour S. Alsaid, Mohammed S. Al-Dosari, Fatma A. Ragab, Abdullah A. Al-Mishari and Abdulaziz N. Almoqbil

Abstract

As a part of ongoing studies in developing new anticancer agents, novel 1,2-dihydropyridine 4, thienopyridine 5, isoquinolines 6–20, acrylamide 21, thiazolidine 22, thiazoles 23–29 and thiophenes 33–35 bearing a biologically active quinoline nucleus were synthesized. The structure of newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against the breast cancer cell line MCF7. 2,3-Dihydrothiazole-5-carboxamides 27, 25, 4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxamide (34), 1,2-dihydroisoquinoline-7-carbonitrile (7), 5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide (35), 1,2-dihydroisoquinoline-7-carbonitrile (6), 2-cyano-3-(dimethylamino)-N-(quinolin-3-yl)acrylamide (21), 1,2-dihydroisoquinoline-7-carbonitriles (11) and (8) exhibited higher activity (IC 50 values of 27–45 μmol L–1) compared to doxorubicin (IC 50 47.9 μmol L–1). LQ quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (12), 2-thioxo-2,3-dihydrothiazole-5-carboxamide (28) and quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (15) show activity comparable to doxorubicin, while (quinolin-3-yl)-1,2-dihydroisoquinoline-7-carbonitrile (9), 2,3-dihydrothiazole-5-carboxamide (24), thieno [3,4-c] pyridine-4(5H)-one (5), cyclopenta[b]thiophene-3-carboxamide (33) and (quinolin-3-yl)-6-stryl-1,2-dihydroisoquinoline-7-carbonitrile (10) exhibited moderate activity, lower than doxorubicin.

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A. Krauze, Z. Andžāns and G. Duburs

Intellectual Property Organization patent , WIPO 2005/042487 A1; C. A., 2005, 142 , 457082g. Krauze, A. A., Garaliene, V. N., Dubur, G. Ya. (1992). Synthesis, properties, and cardiotonic activity of some 2-carbamoylmethylthio-6-phenyl-5-ethoxycarbonyl-3-cyano-4-[pyrid-3-yl]-pyridines and their hydrogenated analogs. Pharm. Chem. J., 26 (5), 411-415. Krauze, A. Viļums, M., Sīle, L., Duburs, G. (2009). Alternative products in one-pot reaction of benzylidene-malononitrile, thiocarbamoylacetamide and halomethyl ketones

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S. Grinberga, A. Krauze, L. Krasnova and G. Duburs

-activity relationships. Bioorg. Med. Chem. Lett., 14 (13), 3411-3414. Pevet, I., Brule, C., Tizot, A., Gohier, A., Cruzalegui, F., Boutin, J. A., Goldstein, S. (2011). Synthesis and pharmacological evaluation of thieno[2,3- b ]pyridine derivatives as novel c-Src inhibitors. Bioorg. Med. Chem., 19 (8), 2517-2528. Wu, J. P., Fleck R., Brickwood, J., Calapilo, A., Catron, K., Chen, Z. D., Kelly, T. A. (2009). The discovery of thienopyridine analogues as potential IκB kinase β inhibitors. Bioorg. Med. Chem. Lett., 19 (19), 5547

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Martin Hrašna, Eva Ürgeová and Alžbeta Krutošíková

References BARAN, P., BOČA, M., BOČA, R., KRUTOŠÍKOVÁ, A., MIKLOVIČ, J. PELIKÁN, J., TITIŠ, J.: Structural characterization, spectral and properties of isothiocyanate nickel(II) complexes with furopyridine derivatives. Polyhedron, 24 2005, 1510-1516. BENCKOVÁ, M., KRUTOŠÍKOVÁ, A.: 5-Aminofuro[3,2- c ]pyridinium tosylates and substituted furo[3,2- c ]pyridine N -oxides: Synthesis and reactions. Collect. Czech. Chem. Commun., 64, 1999, 539-547. BOBOŠÍK, V., KRUTOŠÍKOVÁ, A., JORDIS, U

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Vladimir Sladek and Michal Ilčin

: 1829. Pitoňák M, Riley KE, Neogrády, Hobza P (2008/a) Chem. Phys. Chem. 9: 1636. Singh UC, Kollman PA (1984) J. Comp. Chem. 5: 129. Tsuzuki S, Uchimaru T, Mikami M (2006) J. Phys. Chem. 110: 2027. Sladek V. et al., Ab initio study of the structure and energetic of pyridine dimers Tsuzuki S, Uchimaru T, Matsurama K, Mikami M, Tanabe K (2000) Chem. Phys. Lett. 319: 547. Woon DE, Dunning TH, Jr. (1993) J. Chem. Phys. 98: 1358. Xantheas SS (1996) J. Chem. Phys. 104: 8821.

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Jozef Miklovič, Peter Baran and Roman Boča

References AUGUSTÍN, P., BOČA, R.: Magnetostructural relationships for Fe(III) spin crossover complexes. Nova Biotechnol. Chim., 14, 2015, 96-103. BARAN, P., BOČA, M., BOČA, R., KRUTOŠÍKOVÁ, A., MIKLOVIČ, J., PELIKÁN, P., TITIŠ, J.: Structural characterization, spectral and magnetic properties of nickel(II) complexes with furopyridine derivatives and isothiocyanate. Polyhedron, 24, 2005, 1510-1516. BENCKOVÁ, M., KRUTOŠÍKOVÁ, A.: Synthesis of pyrrolo[2′,3′:4,5]furo[3,2- c ]pyridines. Monatsh. Chem., 126, 1995, 753-758. BOČA, R.: Theoretical