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D. Barski and A. Spodniewska

malathion in blood and liver of rats. Hum Exp Toxicol 22: 205-211. Bajgar J ( 2004 ) Organophosphates/nerve agent poisoning: mechanism of action, diagnosis, prophylaxis, and treatment. Adv Clin Chem 38: 151-216. Barski D, Zasadowski A ( 2006 ) Residues of dimethoate in the liver and AChE activity in blood of rats after exposure to dimethoate, and dimethoate and pyrantel embonate. Pol J Vet Sci 9: 43-49. Barski D, Zasadowski A ( 2008 ) Activity of superoxide dismutase and catalase in erythrocytes

Open access

A. Spodniewska, D. Barski and H. Ziółkowski

185: 202-207. Al-Awthan YS, Al-Douis MA, El-Sokkary GH, Aqlan EM (2012) Dimethoate-induced oxidative stress and morphological changes in the liver of guinea pig and the protective effect of vitamin C and E. Asian Journal of Biological Sciences 5: 9-19. Albonico M, Bickle Q, Haji HJ, Ramsan M, Khatib KJ, Montresor A, Savioli L, Taylor M (2002) Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections. Trans R Soc Trop Med Hyg 96: 685-690. Altuntas I, Kilinc I, Orhan H

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Piotr Jedziniak, Małgorzata Olejnik, Jolanta G. Rola and Teresa Szprengier-Juszkiewicz

Abstract

A multiresidue method (LC-MS/MS) for determination of wide range of anthelmintics was developed. The method covered benzimidazoles: albendazole (and metabolites), cambendazole, fenbendazol (and metabolites), flubendazole (and metabolites), mebendazole (and metabolites), oxibendazole, thiabendazole (and metabolites), triclabendazole (and metabolites); macrocyclic lactones: abamectin, doramectin, emamectin, eprinomectin, ivermectin, moxidectin; salicylanilides: closantel, ioxynil, nitroxynil, oxyclosamide, niclosamide, rafoxanid and others: clorsulon, derquantel, imidocarb, monepantel (and metabolites), morantel, praziquantel, and pyrantel. The method was used to examine the potential presence of anthelmintics in goat and sheep milk and dairy products from the Polish market. A total of 120 samples of milk, yoghurt, cottage cheese, cream cheese, and curd were analysed. None of the samples were found positive above CCα (1-10 μg/kg) except for one cottage cheese in which traces of albendazole sulfone were detected (5.2 ug/kg) and confirmed. The results of the study showed negligible anthelmintic residues in the goat and sheep milk and dairy products and confirm their good quality.

Open access

Aleksandar Cvetkovikj, Ljubica Rashikj, Irena Celeska, Elena Atanaskova Petrov, Branko Angjelovski, Iskra Cvetkovikj, Maja Jurhar Pavlova and Jovana Stefanovska

Abstract

A six-month-old Pomeranian male dog was referred due to a month long history of unformed, soft faeces and mild weight loss. Stool analyses by direct faecal smear, Zinc sulphate flotation and the Baermann concentration method revealed an infection with Strongyloides stercoralis. The dog was initially treated once with a combination drug of praziquantel, pyrantel and febantel (½ Drontal® Plus Tablets for puppies and small dogs; Bayer; i.e. 31.5 mg/kg bodyweight of febantel ). The treatment was repeated after 12 days with the same dosage for 3 consecutive days. The stool analyses performed 14 days and 3 months after the second treatment were negative for S. stercoralis larvae. The results suggest that a repeated treatment with Drontal® Plus Tablets is effective against S. stercoralis in dogs and has no adverse effects.

Open access

Š. Scháňková, M. Maršálek, P. Wagnerová, D. Lukešová, L. Starostová, I. Jankovská, Z. Čadková, M. Kudrnáčová, A. Brožová, J. Truněčková and I. Langrová

[1] Boersema, J. H., Eysker, M., Nas, J. W. M. (2002): Apparent resistance of Parascaris equorum to macrocyclic lactones. Vet. Rec., 150(9): 279–281. DOI: 10.1186/1751-0147-49-25 http://dx.doi.org/10.1136/vr.150.9.279 [2] Brazik, E. L., Luquire, J. T., Little, D. (2006): Pyrantel pamoate resistance in horses receiving daily administration of pyrantel tartrate. J. Am. Vet. Med. Assoc., 228(1): 101–103. DOI: 10.2460/javma.228.1.101 http://dx.doi.org/10.2460/javma.228.1.101 [3] Briggs K

Open access

Melanie Abongwa, Richard J. Martin and Alan P. Robertson

-sensitive nAChRs. PLoS Pathog 2014, 10: e1003870. 26. Trent C, Tsuing N, Horvitz HR: Egg-laying defective mutants of the nematode Caenorhabditis elegans. Genetics 1983, 104: 619-647. 27. Aubry ML, Cowell P, Davey MJ, Shevde S. Aspects of the pharmacology of a new anthelmintic: pyrantel. Br J Pharmacol 1970, 38: 332-344. 28. Martin RJ: Modes of action of anthelmintic drugs. Vet J 1997, 154: 11-34. 29. Austin WC, Courtney W, Danilewicz JC, Morgan DH, Conover LH, Howes HL, Jr., Lynch JE, McFarland JW, Cornwell RL, Theodorides VJ: Pyrantel tartrate, a new

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R. Sokół, M. Raś-Noryńska, M. Michalczyk, A. Jasiecka, H. Ziółkowski and J. Jaroszewski

References Abbott JB, Mellor DJ, Love S ( 2007 ) Assessment of serum protein electrophoresis for monitoring therapy of naturally acquired equine cyathostomin infections. Vet Parasitol 147: 110-117. Bello TR ( 1996 ) Alternative antiparasitic treatment of horses with pyrantel pamoate suspension and ivermectin oral solution compared with horses treated only with ivermectin. J Equine Vet Sci 16: 18-21. Chapman MR, Kearney MT, Klei TR ( 2003 ) Equine cyathostome populations: accuracy of species composition estimations. Vet Parasitol 116: 15

Open access

A. Spodniewska and D. Barski

, Cascales M ( 2005 ) Endogenous antioxidant defence system in rat liver following mercury chloride oral intoxication. J Biochem Mol Toxicol 19: 154-161. Barski D, Spodniewska A ( 2012 ) Activity of selected antioxidative enzymes in rats exposed to dimethoate and pyrantel tartrate. Pol J Vet Sci 15: 239-245. Bebe FN, Panemangalore M ( 2003 ) Exposure to low doses of endosulfan and chlorpyrifos modifies endogenous antioxidants in tissues of rats. J Environ Sci Health B 38: 349-363. Becerra MC, Sarmiento M, Paez PL, Arguello G, Albesa I ( 2004 ) Light

Open access

E. Lyons and S. Tolliver

activity of fenbendazole, ivermectin, oxibendazole, and pyrantel pamoate in horse foals with emphasis on ascarids (Parascaris equorum) in field studies on five farms in Central Kentucky in 2007. Parasitol. Res., 103: 287–291. DOI: 10.1007/s00436-008-0966-8 http://dx.doi.org/10.1007/s00436-008-0966-8 [13] Ryan, W. G., Best, P. J. (1985): Efficacy of ivermectin paste against Strongyloides westeri in foals. Vet. Rec., 117: 169–170. DOI: 10.1136/vr.117.8.169 http://dx.doi.org/10.1136/vr.117.8.169 [14] Todd, A. C., Kelley, G

Open access

I. Bondarenko, J. Kinčeková, M. Várady, A. Kőnigová, M. Kuchta and G. Koňáková

[1] Bekele, T. (2002): Epidemiological studies on gastrointestinal helminths of dromedary (Camelus dromedarius) in semi-arid lands of eastern Ethiopia. Vet. Parasitol., 105(2): 139–152 http://dx.doi.org/10.1016/S0304-4017(01)00583-0 [2] Bell, W. J., Nassif, S. (1971): Comparison of pyrantel pamoate and piperazine phosphate in the treatment of ascariasis. Am. J. Trop. Med. Hyg., 20(4): 584–588 [3] Cebra, C. K., Stang, B. V. (2008): Comparison of methods to detect gastrointestinal