Sofiya Ivanova, Dimitrichka Dimitrova and Metodi Petrichev
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Natalia Francisca Urzúa Pizarro, Carlos Alberto Errecalde, Guillermo Fermin Prieto, Carlos Fernando Lüders, María Paula Tonini and Eduardo Jesús Picco
., Wang, L., Shen, X., Gu, X., Zeng, D., Zeng, Z. (2013). Plasma and tissue pharmacokinetics of marbofloxacin in experimentally infected chickens with Mycoplasma gallisepticum and Escherichia coli. J. Vet. Pharmacol. Ther. 36, 511-515. https://doi.org/10.1111/jvp.12049 PMid:23550715
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Neno Bratoev, Aneliya Milanova, Ivelina Pavlova and Lubomir Lashev
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2. Anadón, A., Martínez-Larra-aga, M.R., Diaz, M.J., Bringas, P., Fernandez, M.C., Fernandez-Cruz, M.L., Iturbe, J., Martínez, M.A. (1994). Pharmacokinetics of doxycycline in broiler chickens. Avian Pathol. 23, 79-90. http
Dimitrichka Dimitrova, Anna Arnaudova-Matey, Petar Dilov, Geno Angelov, Tandju Mehmedov, Toni Todorov, Denka Kushvalieva, Dimitrina Nikolova and Valija Dilova
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4. Kalantaz-Zadeh, K. E., Steja, E
Małgorzata Gbylik-Sikorska, Anna Gajda, Artur Burmańczuk, Tomasz Grabowski and Andrzej Posyniak
1. de Boer V.C., Dihal A.A., van der Woude H., Arts I.C., Wolffram S., Alink G.M., Rietjens I.M., Keijer J., Hollman P.C.: Tissue distribution of quercetin in rats and pigs. J Nutrit 2005, 135, 1718–1725.
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3. Coppin J.P., Xua Y., Chena H., Pan M.H., Hoc Ch.T., Juliani R., Simon J.E., Wu Q
, phosphonomycin amino butyl alcohol three salt granules, and fosfomycin two sodium salt for injection.
Although the clinical application of phosphomycin has increased in recent years, there are few clinical reports in China. According to the related literatures at home and abroad, this review briefly introduces fosfomycin in the following three aspects: progress in synthetic methods, pharmacokinetic and pharmacodynamic characteristics, and antibacterial activities, to provide references for clinical rational use.
The synthesis of fosfomycin
Fosfomycin was first
Artur Burmańczuk, Grabowski Tomasz, Małgorzata Gbylik-Sikorska, Anna Gajda and Cezary Kowalski
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3. Bruno F., Curini R., di Corcia A., Nazzari M., Samperi R.: Solid-phase extraction followed by liquid chromatography
Artur Burmańczuk, Zbigniew Roliński, Cezary Kowalski and Rafał Zań
., Marosevic D., Jaglic Z.: Prevalence of mastitis pathogens in milk from clinically healthy cows. Med Weter 2013, 58, 567–575.
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6. Craigmill A.L., Pass M.A., Wetzlich S.: Comparative pharmacokinetics of AMX administered intravenously to sheep
the control of ocular inflammation in the dog: pharmacokinetics, and clinical results obtained in an experimental model. J Small Anim Pract 1996, 37, 371–375. 10.1111/j.1748-5827.1996.tb02418.x
Roze M. Thomas E. Davot J.L. Tolfenamic acid in the control of ocular inflammation in the dog: pharmacokinetics, and clinical results obtained in an experimental model J Small Anim Pract 1996 37 371 375
17 Ru G., Terracini B., Glickman L.T.: Host related risk factors for canine osteosarcoma. Vet J 1998, 156, 31–39. 10.1016/S1090
Adrian Głogowski, Zbigniew Marczyński, Michał Krzysztof Kołodziejczyk, Jerzy Jambor, Marta Kinga Stefan and Marian Mikołaj Zgoda
Introduction: Dietary supplements are a good way to supplement the deficiency of certain micronutrients and organic components (therapeutic agents) in human body. They are most often available in concentrated form as tablets, capsules, powder or liquid.
Objective: To investigate morphological parameters and the pharmaceutical availability of coated tablets – dietary supplements – that contain selected pharmacopeial titrated dry plant extracts.
Methods: Testing of the effective time of the tablet surface erosion was performed in model acceptor fluids using pharmacopeial methods in static (Erweka apparatus) and dynamic (unlimited diffusion method) conditions. Furthermore, morphological parameters of tablets (the original shape of an ellipse) as well as their hardness were determined.
Results: The effective erosion time was determined by conductometric method using carboxymethylcellulose sodium salt (NaCMC) contained in the tablet. The content of gum arabic and NaCMC in the tablet testifies that the granulate was produced using the “wet granulation” technique which resulted in high hardness of original, esthetic, elliptical tablets and in prolonged disintegration time (erosion).
Conclusions: The used excipients: gum arabic and NaCMC for the production of the tested tablets containing selected dry plant extracts result in their high hardness. The tested dietary supplements are characterized by esthetic design, original shape, and prolonged disintegration time which affects the pharmaceutical availability.