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Dejan Spasovski, Todor Gruev, Nada Marina, Jordan Calovski, Ljubinka Rajčevska, Snežana Perčinkova, Irena Kafeđiska, Kočo Cakalaroski and Maja Slaninka-Micevska

References Vanderlinde RE. Urinary enzyme measurements in the diagnosis of renal disorders. Ann Clin Lab Sci 1981; 11: 189-201. Viergever PP, Swaak AJ. Urine- and serum beta 2-microglobulin in patients with rheumatoid arthritis: a study of 101 patients without signs of kidney disease. Clin Rheumatol 1989; 8: 368-74. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid

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Vanya S. Popova, Svetla O. Blajeva, Margarita L. Alexandrova, Tsvetan H. Lukanov, Silvia Y. Naneva and Nikolay T. Tzvetkov

References 1. Martinelli S, CuneoA, Formigaro L, Cavallari M, Lista E, Quaglia MF, et al. Identifying high-risk chronic lymphocytic leukemia: a pathogenesis- oriented appraisal of prognostic and predictive factors in patients treated with chemotherapy with or without immunotherapy. Mediterr J Hematol Infect Dis. 2016;8(1):e2016047. 2. Montserat E. New prognostic markers in CLL. Hematology Am Soc Hematol Educ Program, 2006;279-84. 3. Bernier GM. beta 2-Microglobulin: structure, function and significance. Vox Sang.1980;38(6):323-7. 4

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Martina Bellini and Paolo Paparella

-6. 4. Jadoul M, Garbar C, Vanholder R, Sennesael J, Michel C, Robert A, et al. Prevalence of histological beta2-micro - globulin amyloidosis in CAPD patients compared with hemodialysis patients. Kidney Int 1998; 54(3): 956-9. 5. Shinohara T, Tatebe M, Okui N, Yamamoto M, Kurimoto S, Hirata H. Cubital tunnel syndrome caused by amyloid elbow arthropathy in long-term hemodialysis patients: report of 4 cases. 6. Barisi} I, Ljuti} D, Vlak T, Bekavac J, Peri} I, Mise K, et al. Beta2-microglobulin plasma level and painful shoulder in

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Marijana Dajak, Svetlana Ignjatović, Biljana Stojimirović, Snežana Gajić and Nada Majkić-Singh

estimating formulae based upon s-cystatin C and s-creatinine and a combination of the two. Nephrol Dial Transplant 2008; 23: 154-60. Wagner C. Cystatin C, renal function and cardiovascular risk. Journal of Medical Biochemistry 2008; 27 (4): 426-31. Sonkar GK, Usha, Singh RG. A preliminary study on the significant value of beta-2-microglobulin over serum creatinine in renal transplant rejection and renal failure. Singapore Med J 2008: 49 (10): 786-9. Lamb E, Newman DJ, Price CP. Kidney Function

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Agnieszka Szymczyk, Aleksandra Nowaczyńska, Maciej Korpysz, Helena Donica, Agnieszka Bojarska-Junak, Monika Długosz-Danecka, Waldemar Tomczak, Ewa Wąsik-Szczepanek and Iwona Hus

clinical stage assessed according to the Rai’s or Binet’s classification, but their main disadvantage is the inability to select the patients in early clinical stages in whom the aggressive course of the disease might be predicted with high probability [ 4 , 5 ]. Many parameters with prognostic value such as: absolute lymphocytes count in peripheral blood, doubling time of lymphocytosis, character of bone marrow infiltration by leukemic lymphocytes, concentration of soluble CD23 and β-2 microglobulin antigen, thymidine kinase and lactate dehydrogenase (LDH

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Jurijs Nazarovs, Regīna Kleina and Sandra Lejniece

), 842–854. Goldschmidt, H., Lannert, H., Bommer, J., Ho, A. D. (2001). Renal failure in multiple myeloma “The myeloma kidney”: State of the art. Saudi J. Kidney Dis. Transplant., 12 (2), 145–150. Greipp, P. R., Katzmann, J. A., O’Fallon, W. M., Kyle, R. A. (1988). Value of beta 2-microglobulin level and plasma cell labeling indices as prognostic factors in patients with newly diagnosed myeloma. Blood, 72 (1), 219–223. Greipp, P. R., San Miguel, J., Durie, B. G. M., Crowley, J. J., Barlogie, B., Bladé, J., Boccadoro, M., Child, J. A., Avet

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Yanjie Bian, Ying Lv and Qingzhang Li

References 1. Bannerman D.D., Chockalingam A., Paape M.J., Hope J.C.: The bovine innate immune response during experimentally-induced Pseudomonas aeruginosa mastitis. Vet Immunol Immunopathol 2005, 107, 201-215. 2. Benoit L.A., Tan R.: Xenogeneic beta 2-microglobulin substitution affects functional binding of MHC class I molecules by CD8+ T cells. J Immunol 2007, 179, 3588-3595. 3. Bertram Y.F., Carmen S.N., Kate P.P.: Fractionation of bovine whey proteins and characterisation by proteomic techniques. Int Dairy J 2008, 18, 23-46. 4. Bian Y.J., Li Q

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Stoyanka Tancheva, Stefka V. Valcheva-Kuzmanova, Radko Zl. Radev, Miroslav D. Marinov, Borislav Boychev, Temenuga Stoeva, Svetlozara K. Boyadjieva and Kiril Sv. Nenov

. Comparison of reliability of tests to distinguish upper from lower urinary tract infection. Br Med J (Clin Res Ed) 1984;289(6440):284-7. 17. Fredriksson А. Renal handling of β2-microglobulin in experimental renal disease. Scand J Clin Lab Invest 1975;35(6):591-600.

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Marijana Dajak

-7. Durie BG, Stock-Novak D, Salmon SE, Finley P, eckord J, Crowley J, et al. Prognostic value of pretreatment serum β 2 microglobulin in myeloma: a Southwest Oncology Group Study. Blood 1990; 75 : 823-30. Durie BG, Salmon SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 1975; 36 : 842-54. Greipp PR, San Miguel J, Durie BG, Crowley JJ, Barlogie B, Blade J, et al. International staging system

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Višnja Ležaić

-8. Cohen MP, Lautenslager GT, Shearman CW. Increased urinary type IV collagen marks the development of glomerular pathology in diabetic d/db mice. Metabolism 2001; 50: 1435-40. Zhou H, Pisitkun T, Aponte A, Yuen PS, Hoffert JD, Yasuda H, et al. Exosomal Fetuin-A identified by proteomics: a novel urinary biomarker for detecting acute kidney injury. Kidney Int 2006; 70: 1847-57. Schaub S, Wilkins JA, Antonovici M, Krokhin O, Weiler T, Rush D, et al. Proteomic-based identification of cleaved urinary beta2-microglobulin as