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Fatemeh Ziaadini, Mohsen Aminae, M.M. Mahsa Rastegar, Sadegh Abbasian and Amir Hossein Memari

O., Bugdayci G., Oxidative stress and lipid peroxidation products: effect of pinealectomy or exogenous melatonin injections on biomarkers of tissue damage during acute pancreatitis. Hepatobiliary. Pancreat. Dis. Int., 2010, 9, 78–82. 18. Coskun S., Ozer C., Gonul B., Take G., Erdogan D., The effect of repeated tryptophan administration on body weight, food intake, brain lipid peroxidation and serotonin immunoreactivity in mice. Mol. Cell. Biochem., 2006, 286, 133–138. 19. Crespo E., Macias M., Pozo D., Escames G., Martin M., Vives F., et al

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Mohammad Amir and Shikha Kumar

production of gastro-intestinal ulcers by anti-inflammatory drugs in rats, Toxicol. Appl. Pharmacol. 50 (1979) 283-289. H. Ohkawa, N. Ohishi and K. Yagi, Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction, Anal. Biochem. 95 (1979) 351-358. B. Galunska, K. Marazova, T. Yankova, A. Popov, P. Frangov, I. Krushkov and D. I. Massa, Effect of paracetamol and propacetamol on gastric mucosal damage and gastric lipid per oxidation caused by acetylsalicylic acid in rats, Pharmacol. Res. 46 (2002) 141

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Anatolii Gordiienko, Mykola Blazheyevskyi and Ivan Iurchenko

tsitoprotektornoy aktivnosti flavonoidov. [Comparisonal investigation of antioxidant properties and cytoprotective activity of flavonoids]. Biokhimiya . 2003;68(5):632-8. 4. Tumanov VA, Gorchakova NO, Gorban’ et al. Pryrodni antioksidantni zasoby v eksperymenti i klinitsi. [Natural antioxidant medications in experiment and clinic]. Fitoterapiia . 2002;3.4:311. 5. Valenzuela A, Lagos C, Schmidt K. Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat. Biochem Pharmacol . 1985;34(4):2209-12. 6. Okuda T, Kimura

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Ayodele J. Akinyemi, Ganiyu Oboh and Adedayo O. Ademiluyi

). Acetylcholine: a neurotransmitter for learning and memory? Brain Res Rev 21 : 285–300. Belle NAV, Dalmolin GD, Fonini G, Rubim MA, Rocha JBT. (2004). Polyamines reduces lipid peroxidation induced by different pro-oxidant agents. Brain Res 1008 : 245–251. Bouchard MF, Sauvé S, Barbeau B, Legrand M, Brodeur, MÈ. (2011). Intellectual impairment in school-age children exposed to manganese from drinking water. Environ Health Perspect 119 : 138–143. Ellman GL, Courtney KD, Andres V, Featherstone RM. (1961). A new and rapid colorimetric determination of

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Abdellah Ali and Phalisteen Sultan

. Oxygen radicals and human disease. Ann Int Med 2001; 107: 526-45. Nikolić-Kokić A, Blagojević D, Spasić B. M. Complexity of free radical metabolism in human erythrocytes. Journal of Medical Biochemistry 2010; 29: 189-95. Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 52: 302-10. Beutler E, Duran O, Kelly BM. Improved method for determination of blood glutathione. J Lab Clin Med 1963; 61: 882-8. Paglia DE, Valentine WN. Studies on the

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M. Szczubiał, M. Kankofer, R. Dąbrowski, M. Bochniarz and R. Urban-Chmiel

, Agarwal A ( 2004 ) Differential growth of human embryos in vitro: role of reactive oxygen species. Fertil Steril 82: 593-600. Benzie IF ( 1996 ) Lipid peroxidation: a review of causes, consequences, measurement and dietary influences. Int J Food Sci Nutr 47: 233-261. Berchieri-Ronchi CB, Kim SW, Zhao Y, Correa CR, Yeum KJ, Ferreira AL ( 2011 ) Oxidative stress status of highly prolific sows during gestation and lactation. Animal 5: 1774-1779. Cadenas S, Aragones J, Landazuri MO ( 2010 ) Mitochondrial reprogramming through cardiac oxygen sensors in

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Nilgün Candan and Leman Tarhan

and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72: 248-254. Buege JA, and Aust SD. 1978. Microsomal lipid peroxidation. Methods in Enzymology 52: 464-478. Clarkson DT. 1988. The uptake and translocation of manganese by plant roots. In: Graham RD, Hannam RJ, Uren NC [eds.], Manganese in Soil and Plants , 101-111. Kluwer Academic Publishers, Dordrecht, The Netherlands. Crosti N, Serviden

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Tatjana Stanković, Vidosava Đorđević, Borislav Kamenov, Hristina Stamenković, Vladan Ćosić, Radovan Milićević and Vjeroslava Slavić

the physiological control or cell function. Physiol Rev 2002; 82: 47-95. Acharyc J, Bunchard NA, Taylor JA, Thompson RPH, Pearson TC. Red cell lipid peroxidation and antioxidant enzymes in iron deficiency. Eur J Haematol 1991; 47: 287-91. Aceto A, Di Hio C, Angelucci S, Tenaglia R, Zezza A, Caccuri AM, et al. Glutathione-related enzyme activities in testis of patients with malignant diseases. Clin Chim Acta 1989; 183: 83-6. Yoshioka T, Bills T, Moore-Jarcelt T, Greene HL, Burr IM, Ichikawa

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Iryna Fomenko, Tetyana Bondarchuk, Vitaliy Emelyanenko, Natalia Denysenko, Sklyarov Pavlo, Iryna Ilkiv, Roman Lesyk and Alexander Sklyarov

Abstract

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) in combination with being physiologically stressed often occurs in in the course of different pathologies. This situation may result in the alteration of digestive system functioning. The effect of stress brings about changes in the activity of nitric oxide synthase (NOS), arginase, cyclooxygenase (COX) and lipid peroxidation, whereas the use of NSAIDs interrupts the multiple functions of the cell via the inhibition of prostaglandins (PGs) synthesis. Taking into account that NOS and COX-systems are connected in their regulation, the aim of the study was to determine the role played by NOS and lipid peroxidation under conditions of the combined action of NSAIDs and stress. In our study, male rats were used. The NSAIDs (naproxen - a non-selective COX inhibitor, celecoxib - a selective COX-2 blocker, and the compound 2A5DHT (which is the active substance of dual COX, and the lipoxygenase (LOX) inhibitor, darbufelone) were all administered at a dose 10 mg/kg, prior to water restraint stress (WRS). WRS brought about an increase of inducible NOS (iNOS) activity in the intestinal mucosal and muscular membranes, as well as in the pancreas. Because of this, constitutive NOS izoform (cNOS) and arginase activities decreased. Moreover, the MDA concentration increased, indicating the development of oxidative stress. In our work, pretreatment with naproxen, as in the WRS model, engendered a decrease in iNOS activity. What is more, administration of Celecoxib did not change iNOS activity, as compared to WRS alone, and it showed a tendency to reduce lipid peroxidation. In addition, 2A5DHT prior WRS brought about a decrease of iNOS activity, with the subsequent rise of cNOS activity. Of note, MDA concentration decreased in all studied organs, indicating the reduction of lipid peroxidation under the action of the darbufelone active substance.

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Tanja Živković Semren, Suzana Žunec and Alica Pizent

-5849(98)00196-8 15. Niedernhofer LJ, Daniels JS, Rouzer CA, Greene RE, Marnett LJ. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells. J Biol Chem 2003;278:31426-33. doi: 10.1074/jbc.M212549200 16. Pamplona R. Advanced lipoxidation end-products. Chem-Biol Interact 2011;192:14-20. doi: 10.1016/j.cbi.2011.01.007 17. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell B 2007;39:44-84. doi: 10.1016/j.biocel.2006.07.001 18. Matés