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Open access

Anna Besedina

Summary

Background: Coronary heart disease is the leading cause of death and disability worldwide. Hypertension is a major independent risk factor for the development of CHD. Abnormalities in NO generation or activity have been proposed as a major mechanism of CHD. The purpose of this article is to determine the activity of eNOS and iNOS in patients with isolated CHD and CHD associated with HT of different age groups.

Methods: Fifty patients with isolated CHD and 42 patients with CHD associated with HT were enrolled in this study. NOS activity was determined by nitrite anion formed in the reaction.

Results: A statistically significant increase in iNOS activity is observed in elderly donors. In patients with isolated coronary heart disease cNOS activity is statistically significantly reduced with respect to the control group. The reduction of enzymatic activity of cNOS is more expressed in elderly patients than in middle-aged patients with coronary heart disease. Alterations in eNOS activity are more expressed in patients with coronary heart disease associated with hypertension than in patients with isolated coronary heart disease. Against the background of cNOS inhibition in the patients, a sharp increase in iNOS activity is observed.

Conclusions: It has been shown that disturbance of endo - thelial function in patients with coronary heart disease associated with hypertension is characterized by reduced endothelial NO synthesis by cNOS and increased systemic NO synthesis due to increased iNOS activity. It has been found that the lack of endothelial NO and hyperproduction of »harmful« NO by iNOS are more expressed in elderly patients.

Open access

Nevena Eremić and Mirjana Đerić

References Ostojić M. Preporuke za prevenciju ishemijske bolesti srca. Prvo izdanje, Beograd: Ministarstvo zdravlja republike Srbije; 2002. The Expert Panel. The Third Report of the National Cholesterol Education Program (NCEP), Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Tratment Panel III). Final report. Circulation 2002; 106: 3143-421. Backer G, Ambrosioni E, Borch-Johansen K, Brotons C, Cifkova R, Dallongeville J, et al

Open access

Amirhossein Sahebkar

Summary

Background: C-reactive protein (CRP) has been proposed as a risk marker and risk factor of cardiovascular disease. There have been a number of clinical reports suggesting that supplementation with L-carnitine can modulate systemic inflammation and lower circulating CRP concentrations, but the results have not been consistent.

Methods: A comprehensive literature search in Medline, Scopus and Cochrane Central Register of Controlled Trials was performed in December 2012 to identify clinical trials investigating the impact of oral L-carnitine supplementation on serum/plasma CRP concentration. A random effect method was used to calculate the combined effect size.

Results: Six studies comprising 541 cases and 546 controls met the inclusion criteria. Meta-analysis of included trials revealed a significant reduction of circulating CRP concentrations in subjects under L-carnitine intervention compared to the control treatment. The calculated combined weighted mean reduction in CRP concentrations was -0.39 mg/L [95% CI (-0.62 - -0.16)]. This effect size estimate was found to be robust and remained unaffected by the removal of each single study.

Conclusions: The overall findings of the present metaanalysis support the clinically relevant benefit of L-carnitine supplementation in lowering the circulating levels of CRP.

Open access

Violeta Iric-Cupic, Srdjan Milanov, Goran Davidovic, Vladimir Zdravkovic, Jelena Vuckovic-Filipovic, Rada Vucic and Ivan Simic

References 1. Vasiljevic-Pokrajcic Z. Ishemijska bolest srca. In: Interna medicina. Manojlovic D. Ed. 191-209. Zavod za udzbenike i nastavna sredstva Beograd, Beograd, 1998. 2. Autman ME, Braunvald E. Acute myocardial infarction, In: Heart disease-A Textbook of cardiovascular Medicine. Braunwald E. Ed. 1184-1289. WB Saunders company, Philadelphia, 1997. 3. Reiner. Ateroskleroza. In: Interna medicina. Vrhovec B. Ed. 718-24. Medicinska biblioteka, Zagreb, 1997. 4. Mahley WR., Bersot PT