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M. Skrzycki, H. Czeczot, M. Majewska, M. Podsiad, W. Karlik, D. Grono and M. Wiechetek

References Beauchamp C, Fridovich I ( 1971 ) Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 44: 276-287. Bojakowska K ( 2006 ) Evaluation of cytotoxicity of cadmium compounds: in vitro studies on rat and equine isolated hepatocytes. Doctoral thesis, Warsaw, Warsaw University of Life Sciences, Poland. Borzęcka K, Bąkała A, Grono D, Głowala A, Wiechetek M ( 2004 ) Evaluation of cadmium cytotoxicity in isolated hepatocytes: effect of

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M. Wójcik, J. Wessely-Szponder and U. Kosior-Korzecka

(2011) Mechanisms of hepatic fibrogenesis. Best Pract Res Clin Gastroenterol 25: 195-206. Masood A, Stark KD, Salem N (2005) A simplified and efficient method for the analysis of fatty acid methyl esters suitable for large clinical studies. J Lipid Res 46: 2299-2305. Ricchi M, Odoardi MR, Carulli L, Anzivino C, Ballestri S, Pinetti A, Fantoni LI, Marra F, Bertolotti M, Banni S, Lonardo A, Carulli N, Loria P (2008) Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. J Gastroenterol

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Lidia Radko, Maria Minta, Piotr Jedziniak and Sylwia Stypuła-Trębas

References 1. Baillie T.A.: Metabolism and toxicity of drugs. Two decades of progress in industrial drug metabolism. Chem Res Toxicol 2008, 21, 129-137. 2. Baliharová V., Skálová L., Maas R.F.M., De Vrieze G., Bull S., Fink-Gremmels J.: The effects of benzimidazole anthelmintics on P4501A in rat hepatocytes and HepG2 cells. Res Vet Sci 2003, 75, 61-69. 3. Capece B.P.S., Navarro M., Arcalis T., Castells G., Toribio L., Perez F., Carretero A., Ruberte J., Arboix M., Cristòfol C.: Albendazole sulphoxide enantiomers

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Petra Rudolfová, Veronika Hanušová, Lenka Skálová, Hana Bártíková, Petra Matoušková and Iva Boušová

, Isolated Hepatocytes: Preparation, Properties and Applications, Elsevier Science Publishers, Amsterdam 1991, pp. 15-58. 24. H. Wang and J. A. Joseph, Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader, Free Rad. Biol. Med. 27 (1999) 612-616; DOI: 10.1016/s0891-5849(99) 00107-0. 25. N. P. Seeram, Y. J. Zhang and M. G. Nair, Inhibition of proliferation of human cancer cells and cyclooxygenase enzymes by anthocyanidins and catechins, Nutr. Cancer 46 (2003) 101-106; DOI: 10.1207/s15327914nc4601

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Miloň Tichý, Marián Rucki, Zdeněk Roth, Iveta Hanzlíková, Alena Vlková, Jana Tumová and Rút Uzlová

estimation by calculation - Tubifex assay and quantitative structure - activity relationships. Environ Toxicol Chem   27 : 2281-2286. Tichy M, Rucki M. (2009). Validation of QSAR models for legislative purposes. Interdiscip Toxicol   2 : 184-186. Tichy M, Pokorna A, Hanzlikova I, Nerudova J, Tumova J, Uzlova R. (2010). Primary rat hepatocytes in chemical testing and QSAR predictive applicability. Toxicology in Vitro   24 : 240-244. Vaal M, van der Wal JT, Hermens J, Hoekstra J. (1997

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Vessela Vitcheva, Magdalena Kondeva-Burdina and Mitka Mitcheva

involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat. Drug Metab Dispos 2000;28:348-53. Carvalho F, Remião F, Amado F, Domingues P, Correia AJ, Bastos ML. D-Amphetamine interaction with glutathione in freshly isolated rat hepatocytes. Chem Res Toxicol 1996;9:1031-6. Yanada H, Oguri K, Yoshimura H. Effects of several factors on urinary excretion of methamphetamine and its metabolites in rats. Xenobiotica 1986;16:137-41. Timbrell J. 2000. Factors

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Mohammad Ali Eghbal, Narges Abdoli and Yadollah Azarmi

References 1. Kashani A, Phillips CO, Foody JM, Wang Y, Mangalmurti S, Ko DT, Krumholz HM. Risks associated with statin therapy: a systematic overview of randomized clinical trials.Circulat ion 2006;114:2788-97. doi: 10.1161/ CIRCULATIONAHA.106.624890 2. Kubota T, Fujisaki K, Itoh Y, Yano T, Sendo T, Oishi R.Apoptotic injury in cultured human hepatocytes induced by HMG-CoA reductase inhibitors. Biochem Pharmacol 2004;67:2175-86. PMID: 15163549 3. Abdoli N, Heidari R, Azarmi Y, Eghbal MA. Mechanisms of the

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J. Pivko, P. Makovický, A. Makarevich, A. Sirotkin, P. Makovický and E. Kubovičová

: Effect of starvation on molecular bodies and rough endoplasmic reticulum in the bovine hepatocytes. Exp. Cell Res., 75, 282-285. 23. Reid, I. M., Collins, R. A., 1980: The pathology of postparturient fatty liver in high-yielding dairy cows. Invest. Cell. Pathol., 3, 237-249. 24. Reid, I. M., Roberts, C. J., Baird, G. D., 1980: The effects of underfeeding during pregnancy and lactation on structure and chemistry of bovine liver and muscle. J. Agri. Sci., 94, 239-245. 25. Savio, J. D., Boland, M. P., Roche, J. P., 1990

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Reza Heidari, Hossein Babaei and Mohammad Ali Eghbal

Laursen S, Norregaard Jensen O, Baunsgaard D. Mechanisms of hydrazine toxicity in rat liver investigated by proteomics and multivariate data analysis . Proteomics 2004;4:868-80. 7. Rana SV, Pal R, Vaiphei K, Ola RP, Singh K. Hepatoprotection by carotenoids in isoniazid-rifampicin induced hepatic injury in rats . Biochem Cell Biol 2010;88:819-34. doi: 10.1139/o10-023 8. Hussain SM, Frazier JM. Cellular toxicity of hydrazine in primary rat hepatocytes . Toxicol Sci 2002;69:424-32. doi: 10.1093/toxsci/69.2.424 9. Chowdhury

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Sara Nafisi, Reza Heidari, Mohammad Ghaffarzadeh, Mojtaba Ziaee, Hossein Hamzeiy, Alireza Garjani and Mohammad Ali Eghbal

JA, Nelson SD, Mitchell JR. Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin. Mol Pharmacol 1977;13:625-33. PMID: 18660 5. Bruno M. Inhibition of protein phosphatase activity and changes in protein phosphorylation following acetaminophen exposure in cultured mouse hepatocytes. Toxicol Appl Pharmacol 1998;153:119-32. PMID: 9875306 6. Larson AM, Polson J, Fontana RJ, Davern TJ, Lalani E, Hynan LS, Reisch JS, Schiødt FV, Ostapowicz G, Shakil AO, Lee WM. Acetaminophen-induced acute liver