Corina Eugenia Budin, Ruxandra Rajnoveanu, Ioana Roxana Bordea, Corina Marginean, Bianca Domokos, Elena Dantes and Doina Adina Todea
mutations and confirmed by the association between nicotine dependence and rs16969968. This allele mutation rs16969968 is responsible for increased addiction in adulthood to those who initiated smoking before 16 years of age. Thus, those who have the present mutation and initiate smoking under the age of 16 have an increased risk of becoming heavy smokers.
Although the genetic risk factor for nicotine addiction is present from birth, the distinct development of smoker/nonsmoker phenotypes and the degree of addiction is also influenced by the environment, which can