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Noora Al-Hammadi, Palmira Caparrotti, Carole Naim, Jillian Hayes, Katherine Rebecca Benson, Ana Vasic, Hissa Al-Abdulla, Rabih Hammoud, Saju Divakar and Primoz Petric

cancer treatment, the number of long-term survivors has increased over the past decades. 8 With larger numbers surviving, more patients become at risk of developing a wide range of late radiation-related side effects. Postoperative radiotherapy in patients with left-sided breast cancer is characterized by exposure of significant portion of the heart volume to high doses of irradiation. 9 Pathophysiology of radiotherapy-induced cardiac toxicity involves damage of blood vessels and interstitial fibrosis, leading to coronary artery disease, valvular abnormalities

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Elias Alibeyki, Saeid Karimkhani, Sepide Saadatmand and Parvaneh Shokrani

tissue to therapeutic radiation. Rep Rradiother Oncol. 2013;1(1):123-127. [8] Gagliardi G, Constine LS, Moiseenko V, et al . Radiation dose-volume effects in the heart. Int J Radiat Oncol Biol Phys. 2010;76(3):S77-S85. [9] Hahn E, Jiang H, Ng A, et al . Late Cardiac Toxicity After Mediastinal Radiation Therapy for Hodgkin Lymphoma: Contributions of Coronary Artery and Whole Heart Dose-Volume Variables to Risk Prediction. Int J Radiat Oncol Biol Phys. 2017;98(5):1116-1123. [10] Jakacki RI, Goldwein JW, Larsen RL, et al . Cardiac dysfunction

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Adriana-Stela Cosma, Claudia Bănescu, Simona Mocan, Beáta Balla and Anca Negovan

E, Tuomilehto J, Puska P - Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland. Circulation. 1999;99(9):1165-72. 26. Shiotani A, Sakakibara T, Yamanaka Y, et al - Upper gastrointestinal ulcer in Japanese patients taking low-dose aspirin. Journal of Gastroenterology. 2009;44(2):126–31. 27. Wen L - Upper Gastrointestinal Complications and Cardiovascular/Gastrointestinal Risk Calculator in Patients with Myocardial Infarction Treated with Aspirin. Chin Med J

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Zh.M. Sizova, V.L. Zakharova, K.A. Alibeyli, O.S. Medvedev, E.V. Shikh, S.B. Bolevich, S.S. Bolevich, S.I. Vorobyev, S.V. Votrin, V.V. Padalko, A.A. Novikov and I.A. Omarov

of the literature. Open Heart 2015; 2: 32-36. 27. Alehagen U, Johansson P, Bjornstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized doubleblind placebo-controlled trial among elderly Swedish citizens. Int J Cardiol. 2013; 167:1860-1866. 28. Sizova ZM, Farafoniva TN, Medvedev OS, et al. Possibilities of different doses coenzyme Q10 administration in patients with chronic heart failure. Heart failure 2010; 11: 218-222. 29. Tokareva OG

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Karthick Raj Mani, Suresh Poudel and K J Maria Das

References [1] International Agency for Research on Cancer (IARC) and World Health Organization (WHO). GLOBOCAN 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012. http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx , 2016. [2] Chanda M. Breast Cancer. In: Lu JJ, Brady LW (Eds.). Radiation Oncology: An Evidence based approach, 1st Edition. Verlag Berlin Heidelberg, Springer; 2008. p. 111-127. [3] Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl

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M. Radik, G. Doka, E. Malikova, P. Krenek and J. Klimas

References [1] Altamirano F, Oyarce C, Silva P, Toyos M, Wilson C, Lavandero S, et al. Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. Journal of Endocrinology 2009;202:299-307. [2] Baggish AL and Wood MJ. Athlete’s Heart and Cardiovascular Care of the Athlete: Scientific and Clinical Update. Circulation 2011;123:2723-2735. [3] Emer E, Yildiz O, Seyrek M, Demirkol S, Topal T, Kurt B, et al. High-dose testosterone and dehydroepiandrosterone induce

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Ivica Ratosa, Aljasa Jenko and Irena Oblak

et al ., where three-quarters of patients were overweight or obese and half of the patients had a Dmax of 107 % or higher, the authors have confirmed the administration of the HF schedule in regard to acute toxic effects to be safe. 36 Lung and heart toxicity The dose-volume predictors for acute and late radiation-induced toxicities are established for the lung and heart as a whole structure. 43 , 44 , 45 Recent studies have evaluated the dose to the whole heart and the proportional increase in cardiac events after BC radiotherapy. An estimated linear

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Karthick Raj Mani, Saumen Basu, Md Anisuzzaman Bhuiyan, Sharif Ahmed, Mostafa Aziz Sumon, Kh Anamul Haque, Ashim Kumar Sengupta, Md Rashid Un Nabi and K. J. Maria Das

early lung toxicity in 3-dimensional conformal irradiation of breast carcinomas. Radiat Oncol. 2013;8:268. [7] Lind PA, Wennverg B, Gagliardi G, et al. Pulmonary complications following different radiotherapy techniques for breast cancer, and the association to irradiated lung volume and dose. Breast Cancer Res Treat. 2001;68(3):199-210. [8] Darby SC, Ewertz M, Mcgale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med. 2013;368(11):987-998.

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Sasa Plecevic, Olga Pechanova, Andrej Barta, Aleksandra Vranic, Jovana Jeremic, Ljiljana Arsenijevic, Nevena Jeremic, Vladimir Jakovljevic, Maja Jevdjevic and Dejan Stanojevic

Chronic Dis. 2013; 4(5): 232-41. 6. Yoshitomi Y, Kawanishi K, Yamaguchi A, et al. Effectiveness of the direct renin inhibitor, aliskiren, in patients with resistant hypertension. Int Heart J. 2013; 54(2): 88-92. 7. Frampton JE, Curran MP. Aliskiren: a review of its use in the management of hypertension. Drugs. 2007; 67(12): 1767-92. 8. Zaporowska-Stachowiak I, Hoffmann K, Bryl W, Minczykowski A. Aliskiren – an alternative to angiotensin-converting enzyme inhibitors or angiotensin receptor blockers in the therapy of arterial hypertension. Arch Med Sci

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Jasmina Sretenovic, Vladimir Zivkovic, Ivan Srejovic and Zoran Milosavljevic

(1):101-21. 4. De Piccoli B1, Giada F, Benettin A, Sartori F, Piccolo E. (1991) Anabolic steroid use in body builders: an echocardiographic study of left ventricle morphology and function. Int J Sports Med 12 (4):408-12. 5. Rocha FL, Carmo EC, Roque FR, Hashimoto NY, Rossini LV, Frimm C, Aneas I, Neagro CE, Krieger JE, Oliveira EM. (2007) Anabolic steroids induce cardiac reninangiotensin system and impair the beneficial effects of aerobic training in rats. Am J Physiol Heart Circulation Physiol, 293(6):H3575-83. 6. Yesalis CE, Bahrke MS. (1995