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Yeltay Rakhmanov, Paolo Enrico Maltese, Alessandra Zulian, Stefano Paolacci, Tommaso Beccari, Munis Dundar and Matteo Bertelli

References 1. Czarny MJ, Resar JR. Diagnosis and Management of Valvular Aortic Stenosis. Clinical Medicine Insights Cardiology 2014; 8(Suppl 1): 15-24. 2. Roberts WC. The congenitally bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol 1970; 26(1): 72-83. 3. Kleinert S, Ott DA, Geva T. Critical discrete subaortic stenosis in the newborn period. Am Heart J1993; 125(4): 1187-89. 4. Darcin OT, Yagdi T, Atay Y, Engin C, Levent E, Buket S, Alayunt EA. Discrete Subaortic Stenosis: Surgical Outcomes and Follow-Up Results. Texas Heart

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Pēteris Tretjakovs, Juris Hofmanis, Dace Hofmane, Gita Krieviņa, Leons Blumfelds, Vitolds Mackēvičs, Aivars Lejnieks and Guntis Bahs

REFERENCES Akahori, H., Tsujino, T., Masuyama, T., Ishihara, M. (2018). Mechanisms of aortic stenosis. J. Cardiol ., 71 (3), 215–220. Ali, O. A., Chapman, M., Nguyen, T. H., Chirkov, Y. Y., Heresztyn, T., Mundisugih, J., Horowitz, J. D. (2014). Interactions between inflammatory activation and endothelial dysfunction selectively modulate valve disease progression in patients with bicuspid aortic valve. Heart , 100 (10), 800–805. Chen, B., Meng, L., Shen, T., Gong, H., Qi, R., Zhao, Y., Sun, J., Bao, L., Zhao, G. (2017). Thioredoxin

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Khai Doan Nang, Michael Reardon, Alan Lumsden and Zsolt Garami

REFERENCES 1. Deeb GM, Reardon MJ, Chetcuti S, et al. 3-Year Outcomes in High-Risk Patients Who Underwent Surgical or Transcatheter Aortic Valve Replacement. J Am Coll Cardiol. 2016;67:2565-2574. doi: 10.1016/j.jacc.2016.03.506. 2. Svensson LG. Transcatheter Aortic Valve Replacement in Moderate-risk Aortic Stenosis Patients. Interventional Cardiology Review. 2014;9:41-43. doi: http://dx.doi.org/10.15420/icr.2011.9.1.41 . 3. Reinöhl J, Kaier K, Reinecke H, et al. Effect of Availability of Transcatheter Aortic-Valve Replacement on Clinical

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M. Kander, U. Pasławska, M. Staszczyk, A. Cepiel, R. Pasławski, G. Mazur and A. Noszczyk-Nowak

S ( 2009 ) Aortic stenosis in dogs: clinical characteristics and survival in 80 cases. Slov Vet Res 46: 125-131. Gregori T, Gomez Ochoa P, Quintavalla F, Mavropoulou A, Quintavalla C ( 2008 ) Congenital heart defects in dogs: a double retrospective study on cases from University of Parma and University of Zaragoza. Ann Fac Medic Vet di Parma 28: 79-90. Höpfner R, Glaus T M, Gardelle O, Amberger C, Glardon O, Doherr MG, Lombard CW ( 2010 ) Prevalence of heart murmurs, aortic and pulmonic stenosis in boxers presented for pre-breeding exams in Switzerland

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Polonca Kogoj, Rok Devjak and Matjaz Bunc

aortic stenosis: benefit of aortic valve replacement. Ann Thorac Surg 2006; 82: 2116-22. 13. Cribier A, Savin T, Saoudi N, Rocha P, Berland J, Letac B. Percutaneous transluminal valvuloplasty of acquired aortic stenosis in elderly patients: an alternative to valve replacement? Lancet 1986; 11: 63-7. 14. Bashore TM, Berman AD, Davidson CJ, Mickel MC, Kennedy W; Davis KB. Percutaneous balloon aortic valvuloplasty. Acute and 30-day follow-up results in 674 patients from the NHLBI Balloon Valvuloplasty Registry. Circulation 1991; 84

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Emilija Antova, Lidija Petkovska, Marijan Bosevski, Jagoda Stojkovik, Nikola Hadzy-Petrushev, Andre Kamkin and Mitko Mladenov

Abbreviations (AS) aortic stenosis (AVA) aortic valve area (AVR) aortic valve replacement (CAD) coronary artery disease (LVEF) left ventricular ejection fraction (LVM) LV mass (AV_Vmax) maximal aortic transvalvular velocity (AV_Max.Grad) maximal transvalvular gradient (Nt-proBNP) N-terminal pro-brain natriuretic peptide (NYHA) New York Heart Association (ROC) receiver operating characteristics REFERENCES 1. Vahanian A, Alfieri O, Andreotti F et al. The Joint Task Force on the Management of Valvular Heart

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Vesela D. Tomova, Tihomir R. Rashev and Milena A. Atanasova

. Rosenhek R, Binder T, Porenta G, Lang I, Christ G, Schemper M, et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med. 2000;343(9):611-7. 4. Trayanov I. [Aortic stenosis and aortic regurgitation], Cardio D. 2007;4(2):34-41. Bulgarian. 5. Otto CM, Lind BK, Kitzman DW, Gersh BJ, Siscovick DS. Association of aortic-valve sclerosis with cardiovascular mortality and morbidity in the elderly. N Engl J Med. 1999;341(3): 142-7. 6. Cosmi JE, Kort S, Tunick PA, Rosenzweig BP, Freedberg RS, Katz ES, et al

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Yeltay Rakhmanov, Paolo Enrico Maltese, Alice Bruson, Tommaso Beccari, Munis Dundar and Matteo Bertelli

aortic valve. Curr Probl Cardiol 2005; 30(9): 470-22. 5. Roberts WC. The congenitally bicuspid aortic valve. A study of 85 autopsy cases. Am J Cardiol 1970; 26(1): 72-83. 6. Steinberger J, Moller JH, Berry JM, Sinaiko AR. Echocardiographic diagnosis of heart disease in apparently healthy adolescents. Pediatrics 2000; 105(4 Pt 1): 815-18. 7. Mack G, Silberbach M. Aortic and pulmonary stenosis. Pediatr Rev 2000; 21: 79–85. 8. Ward C. Clinical significance of the bicuspid aortic valve. Heart 2000; 83(1): 81-85. 9. Michelena HI, Desjardins VA

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Agnieszka Nawara-Baran and Beata Radzymińska-Chruściel

Radzymińska-Chruściel, M Respondek-Liberska, K Januszewska, E Malec. 2014. “First trimester diagnosis of Absent Pulmonary Valve (APV): a case report of prenatal treatment with a review of literature and data from The Polish National Registry of Fetal Cardiac Pathology”. Prenat Cardio 14 (3):18-22 11. Knafel A, M Wiecheć, A Nocuń, A Basta. 2013. “Transposition of great arteries (d-TGA) in the first trimester- a case report”. Prenat Cardio 10 (3): 22-27 12. Hutchinson D,A McBrien, L Howley, Y Yamamoto, A Hirose, T Motan, V Jain, W Savard, LK

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Ali Youssef, Mustafa Alrefae and Sayed Abouelsoud

endocarditis in 30 patients, 1985–2000. Mayo Clin Proc 2001;76:1204–12. [7] Moyssakis I, Tzioufas A, Triposkiadis F, Strateges N, Kyriakidis M. Severe aortic stenosis and mitral regurgitation in a woman with systemic lupus erythematosus. Clin Cardiol 2002;4:194–6. [8] Muscal E, Brey RL. Neurologic manifestations of the antiphospholipid syndrome: integrating molecular and clinical lessons. Curr Rheumatol Rep 2008;10:67–73. [9] Denas G, Jose SP, Bracco A, Zoppellaro G, Pengo V. Antiphospholipid syndrome and the heart: a case series and literature review