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Andrzej Polski, Regina Kasperek, Karolina Sobotka-Polska and Ewa Poleszak

), 995-1017, 2010. 6. Chin J.M. et al.: Caffeine content of brewed teas. J. Anal. Toxicol., 32 (8), 702-704, 2008. 7. Collins S.L. et al.: Oral ibuprofen and diclofenac in post-operative pain: a quantitative systemic review. J. Pain, 2, 285-291, 1998. 8. Conger S.A. et al.: Does caffeine added to carbohydrate provide additional ergogenic benefit for endurance? Int. J. Sport Nutr. Exerc.Metab., 21 (1), 71-84, 2011. 9. Curhan S.G. et al.: Analgesic use and the risk of hearing loss in men.Am. J. Med., 123 (3

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Nivrati Jain, Harshita Jain, Ashish Jain, Veerasamy Ravichandran and Prateek Jain

leukemia cell lines, Eur. J. Med. Chem. 43 (2008) 846 - 852. [10]. A.A. Farag, E.M. Khalifa, N.A. Sadik, S.Y. Abbas, A.G. Alsehemi, A.G. Ammar, Synthesis, characterization, and evaluation of some novel 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents, Med. Chem. Res. 22 (2013) 440 - 452. [11]. R.V. Coombs, R.P. Danna, M. Denzer, G.E. Hardtmann, B. Huegi, G. Koletar, J. Koletar, H. Ott, E. Jukniewicz, Synthesis and antiinflammatory activity of 1-alkyl-4-aryl-2(1H)-quinazolines and quinazolinethiones, J. Med.Chem. 16

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Hanaa Hosni and Mohamed Abdulla

. 72 (1972) 1-42; DOI: 10.1021/cr60275a001. J. M. Ouintela, C. Peinador, L. Botana, M. Estevez and R. Reiguera, Synthesis and antihistaminic activity of 2-guanadino-3-cyanopyridines and pyrido[2,3-d]pyrimidines, Bioorg. Med. Chem. 5 (1997) 1543-1553; DOI: 10.1016/S0968-0896(97)00108-9. F. Monna, F. Chimenti, A. Balasco, B. Bizzarri, W. Filippelli, A. Filippelli and L. Gagliardi, Antiinflammatory, analgesic and antipyretic of 4,6-disubstituted 3-cyano-2-aminopyridines, Eur. J. Med. Chem. 34 (1999) 245-254; DOI

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G Viswanatha, Nagaraju Akinapally, H Shylaja, K Nandakumar, R Srinath and Saravanan Janardhanan

.425. Vogel GH, Vogel WH, Scholkens BA, Sandow J, Muller G, Vogel WF. Drug discovery and evaluation Pharmacological assays. 2nd ed. Springer-Verlag, Berlin, 2002. Hunskar S, Hole K. The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain. Pain. 1987; 30:103-114. Helen WA, Alan C. Standardization of the rat paw formalin test for the evaluation of analgesics. Psychopharmacol. 1991; 104(1): 35-44. Winter EA, Nuss GV. Anti

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Adel Mandour, Eslam El-Sawy, Kamel Shaker and Mohamed Mustafa

References Goodman and Gilman's the Pharmacological Basis of Therapeutics , 7th ed. (Eds. R.J. Flower, S. Moncada and J.R. Vane), MacMillan, New York 1985, p. 695. P. Rani, V.K. Srivastava and A. Kumar, Synthesis and anti-inflammatory activity of heterocyclic indole derivatives, Eur. J. Med. Chem.   39 (2004) 449-452; DOI: 10.1016j.egmech 2003.11.002. S.M. Sondhi, M. Dinodia and A. Kumar, Synthesis, anti-inflammatory and analgesic activity evaluation of some amidine and hydrazone

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Peter O. Osarumwense

-substituted-3H-quinazolin-4-one as analgesic, anti-inflammatory agents, Bioorganic and Medicinal Chemistry 15 (2007) 235-241. Doi: 10.1016/j.bmc.2006.09.065 [4]. K. Baba, K. Takeuchi, F. Hamaski, M. Kozawa, Chemical Studies on the Constituents of the Thymelaeaceous Plants. I.: Structures of Two New Flavans from Daphne odora THUNB, Chemical and Pharmaceutical Bulletin 34 (1986) 595-598. [5]. R. Rohini, P. Muralidhar Reddy, K. Shanker, A. Hu, V. Ravinder, Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c

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Veerachamy Alagarsamy, Durairaj Shankar, Viswas Solomon, Rajendra Sheorey and Periyasamy Parthiban

antiinflammatory drugs: A new generation of cyclooxygenase inhibitors, Angew. Chem. Int. Ed.   38 (1999) 631-633; DOI: 10.1002/(SICI)1521-3773(19990301)38:5<631:: AID-ANIE631>3.0.CO;2-S. V. Alagarsamy, R. Revathi, S. Vijayakumar and K. V. Ramseshu, Synthesis and pharmacological investigation of some novel 2,3-disubstituted quinazolin-4(3 H )-ones as analgesic and antiinflammatory agents, Pharmazie   58 (2003) 233-236; DOI: 10.1002/chin.200330182. V. Alagarsamy, A. Thangathirupathy, S. C. Mandal, S. Rajasekaran, S

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Abdel-Rahman El-Gazzar, Hoda Hussein and Hend Hafez

: 10.1002/1521-4184(200208)335:6 289. P. G. Baraldi, M. G. Pavani, M. Nunez, P. Brigidi, B. Vitali, R. Gambari and R. Romagnoli, Antimicrobial and antitumor activity of N-heteroimine-1,2,3-diathiazoles and their transformation in triazolo-, imidazo- and pyrazolopyrimidines, Bioorg. Med. Chem. 10 (2002) 449-456; DOI: 10.1016/S0968-0896(01)00294-2. S. M. Sondhi, M. Johar, S. Rajvanshi, S. G. Dastidar, R. Shukla, R. Raghubir and J. W. Lown, Anticancer, anti-inflammatory and analgesic activity evaluation of

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Hend Hafez, Hebat-Allah Abbas and Abdel-Rahman El-Gazzar

References A. B. A. El-Gazzar, M. M. El-Enany and M. N. Mahmoud, Synthesis, Analgesic, anti-inflammatory and antimicrobial activity of some novel pyrimido[4,5- d ]quinolin-4-ones, Bioorg. Med. Chem. 16 (2008) 3261-3273; DOI: 10.1016/j.bmc.2007.12.012. D. H. Boschelli, Z. Wu, S. R. Klutchko, H. D. Showalter, J. M. Hamby, G. H. Lu, T. C. Major, T. K. Dahring, B. Batley, R. L. Panek, J. Keiser, B. G. Hartl, A. J. Kraker, W. D. Klohs, B. J. Roberts, S. Patmore, W. L. Elliott, R. Steinkampf, L. A. Bradford, H

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B. Kováčová, T. Foltánová, Š. Kónya and A. Ďurišová

References Bandolier Extra. Evidence-based health care. Acute Pain. 2003. http://www.medicine.ox.ac.uk/bandolier/Extraforbando/APain.pdf Bell WR. Acetaminophen and warfarin. Undesirable synergy. JAMA. 1998; 279(9):702-703. Ben-Bassat J, Peretz E, Sulman FG. Analgesimetry and ranking of analgesic drug by the receptacle method. Arch Int Pharmacodyn. 1959; 122:434-447. Bensenor IM. To use or not to use dipyrone? Or maybe, Central Station versus ER? That is the question. Sao Paulo Med. J