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Zeqir Hashani, Qenan Maxhuni, Rrahman Ferizi, Almir Abdurrahmani and Xhavit Mala

Abstract

Flora of the southern part of Kosovo has previously been studied in a limited way due to the difficult terrain and the fact that up to the 1990s it was a military area. In this paper we report Galanthus elwesii Hook for the first time from Kosovo. This species is found in different habitats, mainly in siliceous substrate or wet meadows of the Dragash Municipality, South Kosovo. This species was collected in the Vraça Mountains, near Restelica, (part of National Park ‘Sharri’) on the road leading to the border with Macedonia. The study area consists of territories belonging to the phytogeographic system Skardon-Pindik (Sharri-Pindi) and includes the mountain ranges of Sharri. This research comprises the presence, description, spread and mapping of the species.

Open access

Bosiljka M. Lalević-Vasić

Abstract

In the early 19th century, after several centuries of slavery, Serbia was liberated and along with the overall organization of the country, health services were formed. The first specialists appeared at the end of the century, among them our first dermatovenereologist, Dr. Jevrem Žujović. He was born in 1860 in Belgrade. He attended high school in Belgrade and in 1885 he graduated from School of Medicine in Paris. Dr. Žujović specialized in dermatovenereology in Paris, with Prof. Fournier as his mentor. He was the first Head of the Department of Skin Diseases and Syphilis at the General Public Hospital since 1889. He organized specialized services all over Serbia. His activity in the work of the Serbian Medical Society was very appreciated. Dr. Žujović studied endemic syphilis and leprosy, and translated A. Fournier’s book “Syphilis and Marriage”, and Loraine’s “Prostitution and Degeneration”. Together with M. Jovanović-Batut, he wrote “Instructions on Syphilis”.

As an Army Medical Officer, Dr. Žujović participated in the Serbo-Bulgarian war (1885), the First and the Second Balkan War and in the First World War (1912 - 1918). He was the vice-president of the Society of the Red Cross of the Kingdom of Yugoslavia, and the first president of the newly-founded Association of Dermatovenereologists of Yugoslavia. He was a recipient of many awards and decorations. Jevrem Žujović retired in 1927, and passed away in 1944.

Open access

Đorđije Karadaglić and Silvija Brkić

Abstract

Despite, the fact that palmoplantar pustulosis is still widely known by this name, it is currently regarded as a disease distinct from psoriasis. The real cause is still unknown. Septic foci have been blamed, but their removal may not cure eruptions. A case series of de novo occurrence of palmoplantar pustulosis induced by tumor necrosis factor-alpha antagonist therapy has been reported. It has been shown that stress may be related to exacerbation of palmoplantar pustulosis. Some authors suggest that palmoplantar pustulosis is an autoimmune disease. In sera of patients with palmoplantar pustulosis circulating autoantibodies against nicotinic acetylcholine receptors were detected. The differences between palmoplantar pustulosis and pustular palmoplantar psoriasis are numerous. Genetic studies have failed to find any link between palmoplantar pustulosis and major genetic susceptibility locus for psoriasis vulgaris. Most patients with palmoplantar pustulosis have no evidence of psoriasis elsewhere. Histologically, it closely resembles psoriasis. However, accumulation of neutrophils just beneath the corneal layer, finding known as Munro’s microabscess, and dilation of capillaries in the papillary dermis are lacking. Approximately 90% of patients are women. A significantly higher prevalence of smokers was found in the group with palmoplantar pustulosis than in the normal population and a particularly strong association was confirmed between smoking and pustular lesions in patients with psoriasis, OR=5.3 (2.1-13.0). Nevertheless, according to a recent review from the Cochrane Library, there is no evidence that smoking cessation improves the condition once it has developed.

Topical corticosteroids under occlusion are the first-line therapy. Prolonged therapy is needed on a second or third-day basis, in order to sustain the obtained effects. Oral retinoids in combination with oral PUVA are the best second-line therapy. No difference in the efficacy between etretinate and acitretin was found. The disadvantage of systemic retinoid therapy is its teratogenicity. Oral PUVA is effective and the response is enhanced by combination with retinoids. There is an established increased efficacy of a combination of retinoids with PUVA therapy over each treatment modallity when used alone. Liarozole may be an effective and well-tolerated therapy, but side effects are like in retinoids. The advantage over acitretin is that raised levels of retinoic acid fall to normal within a few days after cessation of therapy. Significant improvement, but no complete clearance, occurs in most patients treated with low dose cyclosporine. Before starting the treatment, it is necessary to consider: patient’s individual factors, since many patients have already received some previous treatment; specific treatment factors such as formulation, way of administration, dose, different drug combinations; regimens and periods of treatment; site of involvement, due to differences between hands and feet in the probability of response to treatment.