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M Vukovic, N Radlovic, Z Lekovic, K Vucicevic, N Maric, N Kotur, V Gasic, M Ugrin, M Stojiljkovic, L Dokmanovic, B Zukic and S Pavlovic

Introduction Uridin diphospho-glucuronosyl transferases (UGT) are a family of enzymes responsible for glucuronidation of numerous endobiotics, xenobiotics and drugs. Glucuronidation is a process of biotransformation of substrate to water soluble, mainly non-toxic products ready for excretion [ 1 ]. The human UGT superfamily is divided into four families: UGT1A, UGT2, UGT3 and UGT8 [ 2 ]. The UGT1A family is encoded by the UGT1A gene complex located on chromosome 2q37. This gene complex at the 5’ region has 13 variable exons, linked to four common exons at

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Jelena Jordovic, Ksenija Bojovic, Jasmina Simonovic-Babic, Vladimir Gasic, Nikola Kotur, Branka Zukic, Marija Vukovic, Sonja Pavlovic, Ivana Lazarevic, Ivana Bekic, Natasa Nikolic, Aleksandar Uroševic, Nikola Mitrovic and Dragan Delic

List of abbreviations UGT1A1 , uridine diphosphate-glucuronosyl transferase 1A1 GS , Gilbert syndrome TA repeats , thymine-adenine repeats CHC , chronic hepatitis C SVR , sustained virologic responce HIV , human immunodeficiency virus PCR HCV RNA , polymerase chain reaction hepatitis C virus ribonucleic acid DNA , deoxyribonucleic acid ALT , alanine aminotransferase AST , aspartate aminotransferase GGT , gamma-glutamyl transpeptidase AFP , alpha-fetoprotein EOT , end of treatment HCC , hepatocellular carcinoma References

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Jelena Jordovic, Ksenija Bojovic, Jasmina Simonovic-Babic, Vladimir Gasic, Nikola Kotur, Branka Zukic, Marija Vukovic, Sonja Pavlovic, Ivana Lazarevic, Ivana Bekic, Natasa Nikolic, Aleksandar Uroševic, Nikola Mitrovic and Dragan Delic

List of abbreviations UGT1A1, uridine diphosphate-glucuronosyl transferase 1A1 GS, Gilbert syndrome TA repeats, thymine-adenine repeats CHC, chronic hepatitis C SVR, sustained virologic responce HIV, human immunodeficiency virus PCR HCV RNA, polymerase chain reaction hepatitis C virus ribonucleic acid DNA, deoxyribonucleic acid ALT, alanine aminotransferase AST, aspartate aminotransferase GGT, gamma-glutamyl transpeptidase AFP, alpha-fetoprotein EOT, end of treatment HCC, hepatocellular carcinoma References

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Maciej Ostrowski and Anna Jakubowska

References [1] Bajguz A, Piotrowska A. Conjugates of auxin and cytokinin. Phytochem 2009; 70: 957-969. [2] Bowles D, Isayenkova J, Lim E-K, Poppenberger B. Glycosyltransferases: managers of small molecules. Curr Opin Plant Biol 2005; 8: 254-263. [3] Coutinho PM, Deleury E, Davies GJ, Henrissat B. An evolving hierarchical family classification for glycosyltransferases. J Mol Biol 2003; 328: 307-317. [4] Dean JV, Delaney SP. Metabolism of salicylic acid in wild-type, ugt74f1 and ugt74f2

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Kapedanovska A. Nestorovska, K. Jakovski, Z. Naumovska, Hiljadnikova M. Bajro, Z. Sterjev, A. Eftimov, Matevska N. Geskovska, L. Suturkova, K. Dimitrovski, N. Labacevski and A. J. Dimovski

, Labacevski N, Dimovski AJ. Frequency of most common CYP3A5 polymorphisms in the healthy population of the Republic of Macedonia. Macedonian Pharmaceutic Bull. 2012; 58(1-2): 25-31. 26. Hildebrandt MA, Carrington DP, Thomae BA, Eckloff BW, Schaid DJ, Yee VC, et al. Genetic diversity and function in the human cytosolic sulfotransferases. Pharmacogenomics J. 2007; 7(2): 133-143. 27. Horsfall LJ, Zeitlyn D, Tarekegn A, Bekele E, Thomas MG, Bradman N, et al. Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations

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Sonja Pavlović, Branka Zukić and Maja Stojiljković Petrović

with warfarin dose requirement and risk of bleeding complications. Lancet 1999; 353: 717-19. 46. Hoskins JM, Goldberg RM, Qu P, Ibrahim JG, McLeod HL. UGT1A1*28 genotype and irinotecan-induced neutropenia: dose matters. J Natl Cancer Inst 2007; 99: 1290-5. 47. Dokmanović L, Urošević J, Janić D, Jovanović N, Petručev B, Tošić N, et al. Analysis of thiopurine Smethyltransferase Polymorhism in the Population of Serbia and Montenegro and Mercaptopurine Therapy Tolerance in Childhood Acute Lymphoblastic Leukemia. Ther Drug Monit 2006; 28

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Zbigniew Korczewski

on ship propulsion system behavior in rough sea conditions Part 2. The simulation investigations . Polish Maritime Research, No 1(39), Vol. 11, 2004 Dzida M.: Simulation of ship propulsion gas turbine dynamics - an educational laboratory model . Polish Maritime Research, No 4(22), Vol. 6, 1999 Hardin J.R. and others: A gas turbine condition - monitoring system . Naval Engineers Journal, November, USA 1995 Korczewski Z.: Methods of diagnosing the flow section of a naval turbine engine

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Zbigniew Korczewski

controller adjustment on ship propulsion system behavior in rough sea conditions Part 2. The simulation investigations. Polish Maritime Research, No 1(39), 2004, Vol.11. Dzida M.: Simulation of ship propulsion gas turbine dynamics - an educational laboratory model. Polish Maritime Research, No 4(22), 1999, Vol.6. 6. Hardin J. R. and others: A gas turbine condition - monitoring system. Naval Engineers Journal, November, USA 1995. Korczewski Z.: Method of diagnosing the flow section of a

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Zbigniew Korczewski

adjustment on ship propulsion system behavior in rough sea conditions Part 2. The simulation investigations. Polish Maritime Research, No 1(39), 2004, Vol.11. Dzida M.: Simulation of ship propulsion gas turbine dynamics - an educational laboratory model. Polish Maritime Research, No 4(22), 1999, Vol.6. Hardin J. R. and others.: A gas turbine condition - monitoring system. Naval Engineers Journal, November, USA 1995. Korczewski Z.: Method of diagnosing the flow part of a naval turbine engine