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Lack of association between TCF7L2 gene variants and type 2 diabetes mellitus in a Brazilian sample of patients with the risk for cardiovascular disease

Abstract

Objective. Genetic variants in the transcription factor 7-like 2 (TCF7L2) gene have been described as the most noteworthy ones regarding the type 2 diabetes mellitus (T2DM) liability. This work is aimed to evaluate the association between rs12255372 and rs7903146 polymorphisms and T2DM in patients with cardiovascular disease (CAD) risk.

Methods. A sample of six hundred and forty-seven patients that underwent the coronary angiography in a Cardiac Catheterization Lab was evaluated. The patients were investigated for the presence of T2DM and coronary stenosis. The TCF7L2 polymorphisms were genotyped by real-time PCR and the haplotype analysis was performed with the MLOCUS software. All genetic tests were carried out by considering the haplotype combinations in patients divided into three groups: 0 – carrying none disease risk allele, 1 – carrying one or two risk alleles and 2 – carrying three or four risk alleles.

Results. No significant associations between TCF7L2 risk haplotypes and the presence of T2DM or CAD were detected.

Conclusions. Our results indicate that the TCF7L2 rs12255372 and rs7903146 polymorphisms do not influence T2DM in Brazilian patients with the high risk for CAD. Therefore, we assume that these variants may only be relevant for a specific subgroup of T2DM patients or some particular human population.

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Eveningness and its possibility of predicting burnout symptoms among physicians and nurses – preliminary results

Abstract

Introduction.

A sense of burnout may seriously impair one’s functioning and well-being. It may also hamper the quality of care over a patient. The present study therefore assesses sleep quality and chronotype as predictors of a sense of burnout in physicians and nurses of a district hospital.

Material and methods.

The study group comprised 16 physicians and 31 nurses of a district hospital in Central Poland. The participants completed the Link Burnout Questionnaire (LBQ), Chronotype Questionnaire, and Pittsburgh Sleep Quality Inventory. A linear regression model was constructed for each LBQ dimension by means of stepwise elimination. Each model was adjusted to empirical data (p<0.05).

Results.

A rise in Psychophysical exhaustion was predicted by greater scores for Morningness-Eveningness (ME) and Distinctness (DI) of the rhythm. A higher ME score was associated with higher scores in Relationship deterioration and Sense of professional ineffectiveness, with the latter also associated with presence in the nurses group. The nurses group also demonstrated higher Disillusionment and Psychophysical exhaustion scores than the physicians group.

Conclusions.

Eveningness predicted greater burnout in the studied sample. Thus, chronotype should be considered an important burnout risk factor and it can act as a starting point for devising behavioural interventions.

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Protective effects of boron and vitamin E on ethylene glycol-induced renal crystal calcium deposition in rat

Abstract

Objectives. Kidney stone disease is a common form of renal disease. Antioxidants, such as vitamin E (Vit E) and boron, are substances that reduce the damage caused by oxidation.

Methods. Adult male rats were divided into 5 groups (n=6). In group 1, rats received standard food and water for 28 days (control group); in group 2, standard rodent food and water with 0.75% ethylene glycol/d (dissolved in drinking water) (EG Group); in group 3, similar to group 2, with 3 mg of boron/d (dissolved in water) (EG+B Group); in group 4, similar to group 2, with 200 IU of vitamin E injected intraperitoneally on the first day and the 14th day, (EG+Vit E Group); in group 5, mix of groups 3 and 4, respectively (EG+B+Vit E Group).

Results. Kidney sections showed that crystals in the EG group increased significantly in comparison with the control group. Crystal calcium deposition score in groups of EG+B (160), EG+Vit E, and EG+B+Vit E showed a significant decrease compared to EG group. Measurement of the renal tubules area and renal tubular epithelial histological score showed the highest significant dilation in the EG group. Tubular dilation in the EG+B+Vit E group decreased compared to the EG+B and EG+Vit E groups.

Conclusions. Efficient effect of boron and Vit E supplements, separately and in combination, has a complimentary effect in protection against the formation of kidney stones, probably by decreasing oxidative stress.

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Comparison of selected clinical and personality variables in alcohol–dependent patients with or without a history of suicide attempts

Summary

Objective: The aim of the study was to determine differences in the range of socio-demographic variables, selected clinical variables, temperament and character traits, coping with stress strategies and the level of aggression in alcohol addicts with or without a history of suicide attempt(s).

Methods: The study involved 90 people addicted to alcohol, treated in inpatient alcohol dependence treatment program. In order to collect data on socio - demographic variables and selected clinical variables, a self-made questionnaire was used. The severity of alcohol dependence was verified using the MAST and SADD scales. Characteristics of temperament and character were examined with the TCI questionnaire. The BPAQ and COPE questionnaires were used to examine the level of aggression and styles of coping with stress.

Results:Out of 90 subjects with alcohol dependence syndrom, 20% had attempted suicide in the past. The respondents with a history of suicide attempts were statistically significantly younger, were characterized by a younger age of alcohol drinking initiation and the initiation of regular alcohol drinking, and a greater severity of alcohol dependence in the MAST and SADD scales. A significantly larger percentage of respondents who had attempted suicide inflicted self-injury in the past, used other psychoactive substances as well as hypnotics and sedatives. The subjects with a suicide attempt in the interview obtained statistically significantly higher scores in terms of the level of aggression, harm avoidance and self-directedness, and more often used the style of coping with stress based on avoidance and accepting the situation.

Conclusions: The obtained results correspond with data available in the literature and may provide a foundation for theoretical models explaining the phenomenon of suicidal behavior in alcohol addicts as well as for suicide prevention programs in this group of patients.

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TLR4 polymorphisms seem not to be associated with prediabetes and type 2 diabetes but predispose to diabetic retinopathy; TLR4 polymorphisms in glucose continuum

-Larrad MT, Serrano-Rios M, Frechtel GD, Taverna MJ. A functional nonsynonymous toll-like receptor 4 gene polymorphism is associated with metabolic syndrome, surrogates of insulin resistance, and syndromes of lipid accumulation. Metabolism 59, 711–717, 2010. Weintrob N, Amitay I, Lilos P, Shalitin S, Lazar L, Josefsberg Z. Bedside neuropathy disability score compared to quantitative sensory testing for measurement of diabetic neuropathy in children, adolescents, and young adults with type 1 diabetes. J Diabetes Complications 21, 13–19, 2007. Weyrich P, Staiger

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Neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) may be superior to C-reactive protein (CRP) for predicting the occurrence of differentiated thyroid cancer

prostate cancer patients. World J Urol 33, 1661–1667, 2015. Liu CL, Lee JJ, Liu TP, Chang YC, Hsu YC, Cheng SP. Blood neutrophil-to-lymphocyte ration correlates with tumor size in patients with differentiated thyroid cancer. J Surg Oncol 107, 493–497, 2013. McMillan DC. The systemic inflammation-based Glasgow prognostic score: a decade of experience in patients with cancer. Cancer Treat Rev 39, 534–540, 2013. Nozawa H, Chiu C, Hanahan D. Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis. Proc

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Phantom limb phenomenon as an example of body image distortion

leczenie. Warszawa: Springer PWN; 1996. 32. Melzack R. The McGill Pain Questionnaire: major properties and scoring methods. Pain. 1975;1:277–99. 33. Flor H, Nikolajsen L, Staehelin Jensen T. Phantom limb pain: a case of maladaptive CNS plasticity? Nat. Rev. Neurosci. 2006;7:873–81. 34. Li S, Melton DH, Li S. Tactile, thermal, and electrical thresholds in patients with and without phantom limb pain after traumatic lower limb amputation. J. Pain Res. 2015;8:169–74.

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Elevated neutrophil-lymphocyte ratio in patients with euthyroid chronic autoimmune thyreotidis

pediatric ulcerative colitis. J Crohns Colitis 5, 423-429, 2011. Uslu AU, Kucuk A, Sahin A, Ugan Y, Yilmaz R, Gungor T, Bagdaci S, Kucuksen S. Two new inflammatory markers associated with Disease Activity Score-28 in patients with rheumatoid arthritis: neutrophil-lymphocyte ratio and platelet-lymphocyte ratio. Int J Rheum Dis 18, 731-735, 2015. Wang J, Arase H. Regulation of immune responses by neutrophils. Ann N Y Acad Sci 1319, 66-81, 2014. Yao Y, Simard AR, Shi FD, Hao J. IL-10-producing lymphocytes in inflammatory

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LDL and HDL lipoprotein subfractions in multiple sclerosis patients with decreased insulin sensitivity

Framingham risk score of coronary heart disease in middle-aged men with increased non-HDL cholesterol. Int J Cardiol 168, 3853–3858, 2013. Jorissen W, Wouters E, Bogie JF, Vanmierlo T, Noben JP, Sviridov D, Hellings N, Somers V, Valcke R, Vanwijmeersch B, Stinissen P, Mulder MT, Remaley AT, Hendriks JJ. Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL. Sci Rep 7, 43410, 2017. Jorissen W, Vanmierlo T, Wens I, Somers V, Van Wijmeersch B, Bogie JF, Remaley AT, Eijnde BO, Hendriks JJA. Twelve Weeks of

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