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Mostafa Ghorab, Fatma Ragab, Helmy Heiba, Marwa El-Gazzar and Mostafa El-Gazzar

Synthesis, in vitro anticancer screening and radiosensitizing evaluation of some new 4-[3-(substituted)thioureido]-N-(quinoxalin-2-yl)-benzenesulfonamide derivatives

Sulfonamides and quinoxaline derivatives possess many types of biological activities and have been recently reported to show substantial antitumor activity. This paper reports the synthesis of novel thioureido sulfaquinoxaline derivatives. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against a human liver cell line (HEPG2) and showed higher activity than the reference drug doxorubicin. 4-(3-(4-Ethylbenzoate) thioureido)-N-(quinoxalin-2-yl)benzenesulfonamide (9) (IC 50 = 15.6 μmol L-1), N-(pyridin-2-yl)-4-(3-(4-(N-quinoxalin-2-yl-sulfamoyl)phenyl)thioureido)benzenesulfonamide (10) (IC 50 = 26.8 μmol L-1) and N-(quinoxalin-2-yl)-4-(3-(4-(N-thiazol-2-ylsulfamoyl)phenyl)thioureido)benzenesulfonamide (11) (IC 50 = 24.4 μmol L-1) were the most potent compared to doxorubicin (IC 50 = 71.8 μmol L-1). The most potent compounds 9, 10 and 11 were evaluated as radiosensitizing agents by subjecting the compounds to γ-irradiation (8 kGy).

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Anatoliy A. Martynyuk, Bogusław Radziszewski and Andrzej Szadkowski

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The Economy of Bulgaria

Structural Funds, Growth And Cyclical Recurrence

Ivan Todorov, Kalina Durova and Aleksandar Aleksandrov

Open access

Katalin Bukta

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Major Trends in Theoretical and Applied Linguistics 2

Selected Papers from the 20th ISTAL

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The Eurasian Triangle

Russia, The Caucasus and Japan, 1904-1945

Hiroaki Kuromiya and Georges Mamoulia

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Major Trends in Theoretical and Applied Linguistics 3

Selected Papers from the 20th ISTAL

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Beate Jochimsen

Abstract

Federalism is always torn between the principles of subsidiarity and solidarity. Defining the federal structure of a country by finding the welfare-maximizing amount and design of government layers is challenging. Thereby, the financial endowment of different layers of government which they need to fulfill their respective tasks is an important aspect. European countries have chosen quite different federal designs to address the question of an optimal degree of fiscal decentralization. The aim of this paper is to analyze these different approaches for Germany, Italy, and the European Union. Parallels can be found in that all the three entities share a form of institutional asymmetry, a kind of fiscal bailout system, and a sort of fiscal equalization scheme.

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Patrick Idode and Gbenga Sanusi

-1281. Stern R., 2017, Balance of Payments: Theory and Economic Policy , Routledge. Ugur M., 2014, Corruption’s direct effects on per-capita income growth: A meta-analysis , Journal of Economic Surveys, 28(3), pp. 472-490. Wang C., Hong J., Kafouros M., Wright M., 2012, Exploring the role of government involvement in outward FDI from emerging economies , Journal of International Business Studies, 43(7), pp. 655-676.

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Archives of Environmental Protection

The Journal of Institute of Environmental Engineering and Committee of Environmental Engineering of Polish Academy of Sciences