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Ksenija Kramiča, Jeļena Eglīte, Aleksandrs Koļesovs, Tatjana Kramiča, Gaļina Titoviča, Diāna Džeriņa, Glafira Nikolajeva, Ludmila Vīksna and Oksana Koļesova

:// (accessed 17 October 2018). Duarte, R., Carvalho, C., Pereira, C., Bettencourt, A., Carvalho, A., Villar, M., Domingos, A., Barrosb, H., Marques, J., Pinho Costa, P., Mendonça, D., Martins, B. (2011). HLA class II alleles as markers of tuberculosis susceptibility and resistance. Rev. Port. Pneumol. , 17 (1), 15–19. Dubaniewicz, A., Moszkowska, G., Szczerkowska, Z. (2005). Frequency of DRB1–DQB1 two-locus haplotypes in tuberculosis: Preliminary report. Tuberculosis, 85 , 259–267. Kim, H. S., Park, M. H., Song, E. Y., Park, H., Kwon, S. Y., Han, S

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Vladislavs Jasinskis, Oksana Koļesova, Aleksandrs Koļesovs, Baiba Rozentāle, Inga Ažiņa, Ksenija Kramiča, Ludmila Vīksna and Jeļena Eglīte

and/or Nelfinavir: An adult aids clinical trials group study. J. Infect. Dis. , 192 , 1931–1942. Julg, B., Moodley, E. S., Qi, Y., Ramduth, D., Reddy, S., Mncube, Z., Gao, X., Goulder, P. J., Detels, R., Ndung’u, T., Walker, B. D., Carrington, M. (2011). Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection. J. Infect. Dis. , 203 , 803–809. Kapitány, A., Szabó, Z., Lakos, G., Aleksza, M., Végvári, A., Soós, L., Karányi, Z., Sipka, S., Szegedi, G., Szekanecz, Z. (2008). Associations between

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Linda Bāra, Jeļena Eglīte, Pēteris Ošs, Vinita Cauce, Vilnis Lietuvietis, Ludmila Vīksna, Elvīra Hagina and Angelika Krūmiņa

changes in gene expression in septic shock patients: A genome-wide approach. Intensive Care Med. Exp. , 2 (1), 20. Choi, N. M., Majumder, P., Boss, J. M. (2011). Regulation of major histocompatibility complex class II genes. Curr. Opin. Immunol. , 23 (1), 81–87. Eglite, J., Hagina, E., Pavare, J., Grope, I., Gardovska, D., Sochnevs, A. (2010). Polymorphisms of HLA-DRB1* locus and the associations with HMGB1 protein in children with SIRS and sepsis. RSU Research Articles in Medicine & Pharmacy. Rīga Stradiņš University, Rīga, pp. 14–18. Fisher

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Ludmila Vīksna, Jāzeps Keišs, Artūrs Sočņevs, Baiba Rozentāle, Māra Pilmane, Natālija Sevastjanova, Inita Buiķe, Agita Jēruma, Elena Eglīte, Kristīne Ābeltiņa and Valentīna Sondore

Novel Laboratory Tests in Assessment of Liver Function in Acute and Chronic Liver Diseases

Liver biopsy in clinical practice has been widely used for the diagnosis and management of patients with liver diseases, particularly, with chronic liver diseases. However, liver biopsy is an invasive method with potential complications, sampling and interpretation errors. Therefore, noninvasive tests are being developed and introduced to replace liver biopsy. The aim of the present study was to identify the new noninvasive methods to be used for the assessment of liver structure and function, by use of the appropriate serum surrogate markers and to evaluate the clinical diagnostic and prognostic accuracy of these methods, including immunogenetic methods, in cases of acute and chronic liver diseases. The obtained data showed that serum markers of apoptosis (cytokeratin-18 neoepitope and citochrome c) and fibrosis (hyaluronic acid) should be included in viral and toxic liver damage management algorithms. The punctual identification of immunogenetic factors (HLA class II antigens) may prove to be useful in predicting disease evolution, and in guiding the appropriate therapy for patients with poor prognosis.

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Marwoto, Afiono Agung Prasetyo, Ratna Sariyatun, Suradi, Reviono and Harsini

, cause more adverse events, and have lower cure rates [ 9 - 12 ]. Therapeutic responses among MDR-TB patients are not all the same. Independent of socioeconomic factors, malnutrition, and coinfection with other pathogens, genetic factors in MDR-TB patients exert significant influence [ 13 , 14 ]. One of the individual genetic factors involved in the control of TB infection is a polymorphism in the gene coding for the major histocompatibility complex (MHC), also known as human leukocyte antigen (HLA) [ 15 ]. HLA-G is a nonclassical HLA class I antigen that exerts

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Mirko Spiroski, Aleksandar Petlichkovski and Ana Strezova

References Petlichkovski A, Efinska-Mladenovska O, Trajkov D, Arsov T, Strezova A, Spiroski M. High-resolution typing of HLA-DRB1 locus in the Macedonian population. Tissue Antigens. 2004;64:486-91. doi:10.1111/j.1399-0039.2004.00273.x PMID:15361127 Spiroski M, Arsov T, Petlichkovski A, Strezova A, Trajkov D, Efinska-Mladenovska O, Zaharieva E. Case Study: Macedonian Human DNA Bank (hDNAMKD) as a source for public health Genetics. In: Health Determinants in the Scope of New Public Health. Ed. by

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Mirko Spiroski

the HLA population data (AHPD) submitted to the 15th International Histocompatibility/Immunogenetics Workshop by using the Gene[rate] computer tools accommodating ambiguous data (ahpd project report). Tissue Antigens. 2010;76(1):18-30. doi:10.1111/j.1399-0039.2010.01469.x PMID:20331842. Strezova A. Genotyping of HLA-A, HLA-C and HLA-B Loci with Reverse Line Strip Hybridization in Macedonian Population and Association of HLA Class I Alleles with Spondilitis [MSc thesis]. Skopje, Republic of Macedonia: Institute of Immunobiology and Human

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M. Baleva, M. Nikolova-Vlahova, Tsv. Lukanov, M. Ivanova-Shivarova, Zh. Karagjozova, F. Martinova and E. Naumova

-296. 4. Kapitany A, Tarr T, Gytvai A, et al. Human leukocyte antigen-DRB1 and -DQB1 genotyping in lupus patients with and without antiphospholipid syndrome. Ann NY Acad Sci, 2009, 1173, 545-551. 5. Trabace S, Nicotra M, Cappellacci S, et al. of HLA-DR and DQ antigens and anticardiolipin antibodies in women with recurrent spontaneous abortions. Am J Reprod Immunol, 1991, 26 (4), 147-149. 6. Camps MT, Cuadrado MJ, Ocon P, et al. Association between HLA class II antigens and primary antiphospholipid syndrome from the South of Spain. Lupus, 1995, 4 (1

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S. Vojvodić, D. Ademović-Sazdanić and I. Busarčević

G, Funderud S, Bratlie A, Lea T, Ugelstad J, et al. HLA class I and II typing using cells positively selected from blood by immunomagnetic isolation-a fast and reliable technique. Tissue Antigens. 1986; 25(5): 301-312. 11. Vartdal F, Bratlie A, Gaudernack G, Funderud S, Lea T, Thorsby E. Microcytotoxic HLA typing of cells directly isolated from blood by means of antibody-coated microspheres. Transplant Proceedings. 1987; 19(1): 655-657. 12. Walker RH. Technical Manual, 11th ed. Bethesda: American Association of Blood Banks, 1993

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Eli Djulejic, Aleksandar Senev, Meri Kirijas, Slavica Hristomanova, Aleksandar Petlichkovski, Dejan Trajkov and Mirko Spiroski

;101(7):1999-2004. Yunis JJ, Mobini N, Yunis EJ, Alper CA, Deulofeut R, Rodriguez A, Foster CS, Marcus-Bagley D, Good RA, Ahmed AR. Common major histocompatibility complex class II markers in clinical variants of cicatricial pemphigoid. Proc Natl Acad Sci U S A. 1994;91(16):7747-51. Towner P. Purification of DNA. Essential molecular biology (ed. Brown TA). Oxford University Press, Oxford 1995; 47-54. Spiroski M, Arsov T, Petlichkovski A, Strezova A, Trajkov D, Efinska-Mladenovska O, Zaharieva E. Case Study: Macedonian Human DNA Bank