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Open access

Johann Trutz, Aurel Babeș and Katalin Babeș

Abstract

Background and Aims. Several factors are associated with a heightened risk of subsequent events, morbidity and mortality in patients with type 2 diabetes mellitus (T2DM) after an acute coronary syndrome (ACS). Improving the management of these patients is a challenge that requires urgent attention. We aimed to study the long-term effect of the change in treatment strategy depending on the HbA1c level detected during the hospitalization for ACS. Material and methods. The primary endpoints of this study were the major adverse cardiac events (MACE) at 12 months. From the originally included 221 patients 15 were lost (no response to follow-up phone calls). The suboptimal glycaemic control group (HbA1c>7.0%, n=84) was divided in two subgroups: patients who completed a diabetological consult with further treatment changes (intervention group) and patients without this referral (control group). Results. No significant differences in baseline characteristics were found between the 2 subgroups. The second subgroup had a triple risk for a MACE in 1 year (HR=2.8704, 95% CI: 1.109-7.423, p=0.0296) compared to the intervention group. No significant differences were found in secondary endpoints. Conclusion. This study suggests that, after hospitalization for an ACS, diabetologist referral and treatment strategy changes are recommended for all T2DM patients whose HbA1c level is over 7% before discharge.

Open access

Xiao-huan Gong, Jin-ming Yu, Yong Mao and Da-yi Hu

Introduction Acute coronary syndrome (ACS) encompasses unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STE-MI). UA and NSTE-MI are classified as non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Life-threatening NSTE-ACS is a leading cause of emergency and hospitalization in the United States. [ 1 ] It causes a lot of public expenditures. Its cost might account for a large proportion of worldwide health care expenditures in the future. [ 2 ] The basic medicine for

Open access

Johann Trutz, Aurel Babeş and Katalin Babeş

Abstract

Background and Aims. The identification of type 2 diabetes mellitus (T2DM) patients with high cardio-vascular risk became more crucial, especially in patients with known coronary artery disease (CAD). Our study is focusing on T2DM patients who suffered recently an acute coronary syndrome (ACS), and evaluates the importance of albuminuria and NT-proBNP level as risk factors for short-term recurrence.

Material and methods. 221 T2DM patients with recent ACS were evaluated 1 month after discharge, assessing NT-proBNP and albuminuria level and followed for 12 months for major adverse cardiac events (MACE).

Results. Patients who reached the endpoint (33%) presented significantly higher levels of NT-proBNP (458.5 vs. 207.4 pg/ml, p<0.0001) and urinary albumin/creatinine ratio (80 vs. 27 mg/g, p<0.0001) than those who did not present a MACE in the follow-up period. Comparison of the MACE-free survival curves revealed that NT-proBNP has a better power than albuminuria in the prediction of the short-term outcome: hazard ratio (HR)=1.6176 (95%CI: 1.0047-2.6044), p=0.0433 vs. HR=1.4813 (95%CI: 0.8497-2.5824), p=0.1921. Only the NT-proBNP level entered the multivariable regression model besides age and represents an independent risk factor (HR=1.0025, 95%CI: 1.0014-1.0035, p=0.0036).

Conclusion. NT-proBNP provides excellent prognostic information in patients with diabetes mellitus who recently suffered an ACS. Albuminuria wasn’t an independent risk factor in this cohort.

Open access

Tiberius Mogoş, Carmen Dondoi, Claudia Chelan and Andra Evelin Iacobini

16, 2013 at http://www.cancer.org/acs/groups/cid/documents/webcontent/003022-pdf.pdf 3. American Cancer Society Web Site . Atlanta, Ga: American Cancer Society, 2013. Available online. Last accessed October 15, 2013 at http://www.cancer.org/index 4. American Institute for Cancer Research . AICR Brochures. Washington, DC: AICR, 2010. Available online. Last accessed October 9, 2013 at http://preventcancer.aicr.org/site/PageServer?pagename=aicr_publications_brochures 5. Fleischauer AT, Arab L . Garlic and cancer: A critical review of the

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Justin S. Michael, Bong-Seop Lee, Miqin Zhang and John S. Yu

T, Wang HQ, Pantoja JL, Yoon CW, Hanson CJ, et al . Reactive oxygen species responsive nanoprodrug to treat intracranial glioblastoma. ACS Nano 2013;7:3061-77. 10.1021/nn400347j Lee BS Amano T Wang HQ Pantoja JL Yoon CW Hanson CJ et al Reactive oxygen species responsive nanoprodrug to treat intracranial glioblastoma ACS Nano 2013 7 3061 – 77 41 Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, et al . An integrated genomic analysis of human glioblastoma multiforme. Science 2008;321:1807-12. 10.1126/science.1164382 Parsons DW

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Konstantinos V. Voudris and Mladen I. Vidovich

the impact of practicing “defensive medicine” is considered, the economic costs are even higher both for the health system as well as for medical services consumers who face increased medical care costs. [ 18 ] In this setting, TRA has emerged as a reliable alternative to the traditional femoral approach. TRA has been shown to reduce mortality both in ST-segment elevation myocardial infarction [ 19 ] and non-ST-segment elevation acute coronary syndrome (NSTE ACS) [ 20 ] . Equally important, in patients with acute coronary syndromes, TRA and TRA PCI have been

Open access

Hongting Wang, Zuan-tao Lin, Yulin Yuan and Tianfu Wu

-14. 10.1021/acs.jproteome.5b00905 Wu T Ding H Han J Arriens C Wei C Han W et al. Antibody-Array-Based Proteomic Screening of Serum Markers in Systemic Lupus Erythematosus: A Discovery Study J Proteome Res 2016 15 2102 14 41 Wu T, Xie C, Wang HW, Zhou XJ, Schwartz N, Calixto S, et al . Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. J Immunol 2007; 179: 7166-75. 10.4049/jimmunol.179.10.7166 Wu T Xie C Wang HW Zhou XJ Schwartz N Calixto S et al. Elevated urinary VCAM-1

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Wynford R. Williams

, Yan BC, Kang IJ, Shin BN, Lee YL, Shin MC, Cho JH, Lee YJ, Jeon YH, Won MH, Ahn JH. Melatonin improves cognitive deficits via restoration of cholinergic dysfunction in a mouse model of scopolamine-induced amnesia. ACS Chem Neurosci 9, 2016-2024, 2018. Cheng XP, Sun H, Ye ZY, Zhou JN. Melatonin modulates the GABAergic response in cultured rat hippocampal neurons. J Pharmacol Sci 119, 177-185, 2012. Coloma FM, Niles LP. Melatonin enhancement of [3H]-gamma-aminobutyric acid and [3H]muscimol binding in rat brain. Biochem Pharmacol 37

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Heba A. Abdel-Hamid, Mona M. I. Abdalla, Nagwa M. Zenhom and Rasha F. Ahmed

-analogue continuously administered in mice. Bioorg Med Chem Lett 27, 3829–3832, 2017a. Nishizawa N, Niida A, Masuda Y, Kumano S, Yokoyama K, Hirabayashi H, Amano N, Ohtaki T, Asami T. Antiobesity effect of a short-length peptide YY analogue after continuous administration in mice. ACS Med Chem-Lett 8, 628–631, 2017b. Panigrahi G, Panda C, Patra A. Extract of Sesbania grandiflora ameliorates hyperglycemia in high fat diet-streptozotocin induced experimental diabetes mellitus. Scientifica (Cairo) 2016, 4083568, 2016. Pari L, Chandramohan R. Modulatory effects of

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Laura M. L. Carvalho, Fernando M. dos Reis, Ana Lucia Candido, Fernanda F. C. Nunes, Claudia N. Ferreira and Karina B. Gomes

, Ma J, Xie X. Association of IRS-1 and IRS-2 genes polymorphisms with polycysticovary syndrome: a metaanalysis. Endocr J 59, 601-619, 2012. Sales MF, Soter MO, Candido AL, Fernandes AP, Oliveira FR, Ferreira ACS, Souza MO, Ferreira CN, Gomes KB. Correlation between plasminogen activator inhibitor-1 (PAI-1) promoter 4G/5G polymorphism and metabolic/ proinflammatory factors in polycystic ovary syndrome. Gynecol Endocrinol 29, 936-939, 2013. Sam S. Obesity and Polycystic Ovary Syndrome. Obes Manag 3, 69-73, 2007. Santos