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in humans. Diabetologia. 2005;48(11):2330-3. 8. Fukuhura A, Matsuda M, Nishizawa M. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005;5708(307):426-30. 9. Saddi-Rosa P, Olivera C, Giuffrida F, Reis A. Visfatin, glucose metabolism and vascular disease: a review of evidence. Diabetol Metab Syndr. 2010; 26;2:21. doi: 10.1186/1758-5996-2-21. 10. Christov Vl, Gocheva N, Petkova M, Zaharieva S, Tankova Tz, Orbetzova M, et al. A consensus of the Bulgarian Institute Metabolic Syndrome. Nauka Endocrinologia. 2010;2:3-70. (in

References 1.Revollo JR, Korner A, Mills KF, Satoh A, Wang T, Garten A, Dasgupta B, Sasaki Y, Wolberger C, Townsend RR, Milbrandt J, Kiess W, Imai S. Nampt/ PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab. 2007;6(5):363-75; DOI:10.1016/j. cmet.2007.09.003. 2. Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annu Rev Nutr. 2008;28:115-30; DOI:10.1146/annurev. nutr.28.061807.155443. 3. Houtkooper RH, Canto C

–3129, 2003. Gabay O, Hall DJ, Berenbaum F, Henrotin Y, Sanchez C. Osteoarthritis and obesity: experimental models. Joint Bone Spine 75, 675–679, 2008. Goggins J, Baker K, Felson D. What WOMAC pain score should make a patient eligible for a trial in knee osteoarthritis? J Rheumatol 32, 540–542, 2005. Gosset M, Berenbaum F, Salvat C, Sautet A, Pigenet A, Tahiri K, Jacques C. Crucial role of visfatin/pre-B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: Possible influence on osteoarthritis. Arthritis Rheum 58, 1399–1409, 2008

S, Sotiropoulos G, Kar ma - niolas K, Pelekanos N, Papadavid E, et al. Could serum visfatin be a potential biomarker for postmenopausal breast cancer? Maturitas 2012; 71: 301-8. 11. Kelesidis I, Kelesidis T, Mantzoros CS. Adiponectin and cancer: a systematic review. Br J Cancer 2006; 94: 1221-5. 12. Moon HS, Liu X, Nagel JM, Chamberland JP, Diako - poulos KN, Brinkoetter MT, et al. Salutary effects of adiponectin on colon cancer: in vivo and in vitro studies in mice. Gut 2012. 13. Fujisawa T, Endo H, Tomimoto A, Sugiyama M, Taka - hashi H, Saito S, et al

References Abu Aboud O, Chen CH, Senapedis W, Baloglu E, Argueta C, Weiss RH. Dual and specific inhibition of NAMPT and PAK4 by KPT-9274 decreases kidney cancer growth. Mol Cancer Ther 15, 2119–2129, 2016. Alaee M, Khaghani S, Behroozfar K, Hesari Z, Ghorbanhosseini SS, Nourbakhsh M. Inhibition of ncotinamide phosphoribosyltransferase induces apoptosis in estrogen receptor-positive MCF-7 breast cancer cells. J Breast Cancer 20, 20–26, 2017. Annie L, Gurusubramanian G, Roy VK. Estrogen and progesterone dependent expression of visfatin/NAMPT regulates proliferation

. Diabetes 2008;57(6):1501-7. 29. Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005;307:426-30. 30. Yang RZ, Lee MJ, Hu H, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 2006;290:E1253-61. 31. Tan BK, Adya R, Farhatullah S, et al. Metformin treatment may increase omentin-1 levels in women with polycystic ovary syndrome. 2010;59(12):3023-31.

JW. et al. Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study. Clin Endocrinol (Oxf) 2008; 69: 885-93. 26. Cambuli VM, Musiu MC, Incani M, Paderi M, Serpe R, Marras V. et al. Assessment of adiponectin and leptin as biomarkers of positive metabolic outcomes after lifestyle intervention in overweight and obese children. J Clin Endocrinol Metab 2008; 93: 3051-7. 27. Hu E, Liang P, Spiegelman BM. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem

References 1. Bauer S. et al.: Systemic resistin is increased in type 2 diabetic patients treated with loop diuretics. J. Diabetes Complications, 2011, 25:377-381. 2. Cao H., Hegele R.: Single nucleotide polymorphisms of the resistin (RSTN) gene. J. Hum Genet., 2001; 46: 553-555. 3. Ebtesam A Al-Suhaimi, Adeeb Shehzad.: Leptin, resistin and visfatin: the missing link between endocrine metabolic disorders and immunity. European Journal of Medical Research, 2013, 18:12. 4. Fujinami A. et al.: Enzyme-linked immunosorbent assay for circulating human resistin

human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Med 1995; 1: 1155-61. Halaas JL, Boozer C, Blair-West J, et al. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997; 94: 8878-83. Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005; 307: 426-30. Brendt J, Kling N, Kralishc S, et al. Plasma Visfatin concentrations and fat depot-specific mRNA expression in

Plasminogen Activator Inhibitor–1 by Macrophages. Sci Trans Med. 2010 Febr;2(20):15-20. 53. Oki K, Yamane K, Kamei N, Nojima H, Kohno N. Circulating visfatin level is correlated with inflammation, but not with insulin resistance. Clin Endocrinol. 2007;67:796–800. DOI: 10.1111/j.1365-2265.2007.02966.x 54. Jurdana M, Petelin A, Cernelic Bizjak M, Bizjak M, Biolo G, Jenko-Praznikar Z. Increased serum visfatin levels in obesity and its association with anthropometric/biochemical parameters, physical inactivity and nutrition. eSPEN Journal. 2013 Apr;8(2):e59-67. DOI: 10.1016/j