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REFERENCES 1. M. Song, Recent developments in small molecule therapies for renal cell carcinoma, Eur. J. Med. Chem. 142 (2017) 383–392; 2. P. Mendiratta, B. I. Rini and M. C. Ornstein, Emerging immunotherapy in advanced renal cell carcinoma, Urol. Oncol. 35 (2017) 687–693; 3. S. M. Yu, D. H. Hu and J. J. Zhang, Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells, Mol. Med. Rep. 12

., LEHOTAY, J., SPIŠSKÁ, Ľ.: Examination of the chemical composition of propolis VIII. Extraction of coumarins from propolis samples. (in Slovak) Farm. Obzor, 82, 2013, 17-21. IKEDA, R., WADA, M., NISHIGAKI, T., NAKASHIMA, K.: Quantitation of coumarin derivatives in Noni ( Morinda citrifilia ) and their contribution of guenching effect on reactive oxygen species. Food Chemistry, 113, 2009, 1169-1172. JURD, L., KING, A. D., JR., MIHARA, K.: Antimicrobial properties of umbelliferone derivatives. Phytochemistry, 10, 1971, 2965-2970. MALIK, A., KUSHNOOR, A., SAINI, V., SINGHAL

to be unravelled for cytochrome P450 enzymes. Phytochem. Rev. 5, 2006, p. 293-308. TOYAMA, D. O. - MARANGONI, S. - DIZ-FILHO, E. B. S. - OLIVEIRA, S. C. B. - TOYAMA, M. H.: Effect of umbelliferone (7-hydroxycoumarin, 7-HOC) on the enzymatic, edematogenic and necrotic activities of secretory phospholipase A2 (sPLA2) isolated from Crotalus durissus collilineatus venom. Toxicon 53, 2009, p. 417-426. KAKÁČ, B. - VEJDĚLEK, Z. J. - HACHOVÁ, E.: Handbuch der Kolorimetrie. Veb Gustav Fischer Verlag, Jena, 1962, p. 626-627. VAĽKO, V. - ČERNOCHOVÁ, S. - GRANČAI, D.: The

REFERENCES 1. Akulshina E.V. and Darmohray V.N., Results development of techniques chromatospectrometrical definitions of herniarin and umbelliferone in the herb of Herniaria polygama. J. Rossiyskij mediko-biologicheskij vestnik imeni akademika I.P. Pawvlova , 3, 147, 2010. 2. Chen Y. et al, Analysis of the monosaccharide composition of purified polysaccharides in Ganoderma atrum by capillary gas chromatography. J. Phytochem Anal., 20 (60), 503, 2009. 3. Ecoflora of Ukraine . Volume 3. Editor in chief Ya Didukh, 2002, Phytosociocentre, Kiev p.495. 4. Freiler

capacity of glycan extracted from Cynomorium songaricum. Int. J. Biol. Macromol., 2011, 48, 5, 788-792. 39. Sodd u G., Sanjust E., Murgia S., Rescigno A., Interference of some tryptophan metabolites in the formation of melanin in vitro. Pigment Cell Res., 2004, 17, 2, 135-141. 40. Sollai F., Zucca P., Sanjust E., Steri D., Rescigno A., Umbelliferone and esculetin: Inhibitors or substrates for polyphenol oxidases? Biol. Pharm. Bull., 2008, 31, 12, 2187-2193. 41. Traka M.H., Mithen R.F., Plant science and human nutrition: Challenges in assessing health-promoting properties

expressed as pyrogallol were 1.68–1.99 %. The content of tannins expressed as pyrogallol were 0.22–0.59 %. The content of total flavonoids expressed as hyperoside were 1.31–1.63 %. The content of hydroxycinnamic derivatives expressed as rosmarinic acid were 1.15–0.47%. The content of coumarins expressed as umbelliferone were 0.22 –0.33 %. Volatile oils were isolated (from dry plant materials) by hydrodistillation. The content of essential oil in Sideritis raeseri herba were 60–65 ml/kg. cOncLUSIOnS: This pilot study quantified some secondary metabolites of the