Jitka Mužíková, Sandra Muchová, Alena Komersová and Václav Lochař
The paper studies the compressibility of directly compressible tableting materials with dry binders, spray-dried lactose and microcrystalline cellulose, and glyceryl dibehenate at various concentrations. Compressibility was evaluated by means of the energy profile of compression and tensile strength of tablets. Release rate of the active ingredient, salicylic acid, from the tablets was also examined. In the case of microcrystalline cellulose, a higher concentration of glyceryl dibehenate increased the strength of tablets, while this did not occur in the case of spray-dried lactose. Increasing concentration of glyceryl dibehenate prolonged the release of salicylic acid; however, no statistically significant difference was found compared to the type of the dry binder used
The paper evaluates and compares the compressibility and compactibility of directly compressible tableting materials for the preparation of hydrophilic gel matrix tablets containing tramadol hydrochloride and the coprocessed dry binders Prosolv® SMCC 90 and Disintequik™ MCC 25. The selected types of hypromellose are Methocel™ Premium K4M and Methocel™ Premium K100M in 30 and 50 % concentrations, the lubricant being magnesium stearate in a 1 % concentration. Compressibility is evaluated by means of the energy profile of compression process and compactibility by the tensile strength of tablets. The values of total energy of compression and plasticity were higher in the tableting materials containing Prosolv® SMCC 90 than in those containing Disintequik™ MCC 25. Tramadol slightly decreased the values of total energy of compression and plasticity. Tableting materials containing Prosolv® SMCC 90 yielded stronger tablets. Tramadol decreased the strength of tablets from both coprocessed dry binders.
Jitka Mužíková, Alena Komersová, Václav Lochař, Lucie Vildová, Bára Vošoustová and Martin Bartoš
This paper evaluates and compares the properties of directly compressible tabletting materials and matrix tablets containing a combination of α-lactose monohydrate and microcrystalline cellulose in the 3:1 ratio in a physical mixture and in a coprocessed dry binder. Tested parameters include flow properties, compressibility, compactibility and the rate of drug release from tablets. Compressibility is evaluated by means of the energy profile of the compression process. Compactibility is evaluated by means of the tensile strength of the tablets. Dissolution testing is done using the rotating basket method. Dissolution profiles are evaluated by non-linear regression analysis.
Total energy of compression and plasticity values were higher in tabletting materials with the coprocessed dry binder. Increasing additions of polyvinyl alcohol decreased the values of total energy of compression, plasticity, tensile strength of tablets and drug release rate. Dissolution behaviour of tablets, which contained the physical mixture or coprocessed dry binder and the same amount of polyvinyl alcohol, was comparable.
optimal formulation, Drug Dev. Ind. Pharm. 29 (2003) 565-574; DOI:10.1081/DDC-120018645.
A. Mckenna and D. F. McCafferty, Effect of particle size on the compaction mechanism and tensilestrengthoftablets, J. Pharm. Pharmacol. 34 (1982) 347-351.
R. L. Carr, Evaluating flow properties of solids, Chem. Eng. 72 (1965) 163-168.
Unated States Pharmacopeia 24, National Formulary 19, USP Convention, Rockville, 2000.
O. A. Odeku and J. T. Fell, Evaluation of Khaya gum
Maja Šantl, Ilija Ilić, Franc Vrečer and Saša Baumgartner
particle size on the compaction mechanism and tensilestrengthoftablets, J. Pharm. Pharmacol. 34 (1982) 347_351; DOI: 0.1111/j.2042-7158.1982.tb04 727.x.
4. H. Vromans, A. H. De Boer, G. K. Bolhuis, C. F. Lerk and K. D. Kussendrager, Studies on tableting properties of lactose. Part I. The effect of initial particle size on binding properties and dehydration characteristics of lactose, Acta Pharm. Suec. 22 (1985) 163_172.
5. A. H. De Boer, H. Vromans, C. F. Lerk, G. K. Bolhius, K. D. Kussendrager and H. Bosch, Studies on tableting