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intestinal microbiota. Probiotics may affect intestinal barrier function and exert anti-inflammatory actions. 12 To date, many clinical studies have investigated the effects of probiotics in IBS patients, and these studies demonstrated that probiotic administration is effective in IBS patients. In this article, we summarize the systematic reviews and meta-analysis of the effectiveness of probiotics on IBS, evaluate the quality of the report and methodology, explore the influencing factors, providing strong evidence for the development of related work, and regulate the

progressed after the failure of a bevacizumab-based first line chemotherapy were randomized to continuation or suspension of bevacizumab. The chemotherapy backbone was changed. They both showed that continuation of bevacizumab can effectively improve survival, even if to a small amount. In order to verify if this strategy could be generalized to all the VEGF-targeting drugs, we conducted a systematic review of all the literature available regarding the administration of antiangiogenic drugs targeting VEGF pathway after failure of a previous antiangiogenic therapy and

autoimmune thyroid disorders. Int J Immunopathol Pharmacol 19, 31–36, 2006. Megdal SP, Kroenke CH, Laden F, Pukkala E, Schernhammer ES. Night work and breast cancer risk: A systematic review and meta-analysis. Eur J Cancer 41, 2023–2032, 2005. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6, e1000097, 2009. Moon SH, Lee BJ, Kim SJ, Kim HC. Relationship between thyroid stimulating hormone and night shift work. Ann Occup Environ Med 28, 53, 2016. Rizza S, Neri A

, most older depressed adults are excluded from the existing treatment guidelines and well-designed RCTs and meta-analyses, which means that there is a great lack of evidence to manage these patients in real clinical practice. Thus, the main aim of this paper was to identify the data on antidepressant treatment in depressed older adults on polypharmacy using a systematic review approach. Methods Search Strategy Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines-review protocol was used to conduct this review and this is summarized in

country, which has been considered as a barrier of help seeking ( Suryadevara & Tandon 2018 ; Salam et al. 2017 ; Khan 2005 ; Arafat 2017 ; Shah et al. 2017 ). Therefore, the author aimed at critical appraising different aspects of suicide in Bangladesh based on the available literature and systematic search. Methods Literature searching For the critical appraisal of suicide in Bangladesh, the author conducted a systematic review of the following databases: PubMed, PubMed Central, Scopus, Google, Google Scholar and BanglaJOL. The relevant literature search was

receptors in the brain ( Mao et al., 2015 ). Finally, ( Lishmanov et al., 1987 ) reports that studies have also shown that R. rosea promotes an increase in β-endorphins, which lowers the intensity of the stress response and the production of endorphins at stressful situations. In other words, the herb acts by decreasing or totally preventing stress-induced hormonal changes, by its adaptogenic properties ( Figure 1 ). Figure 1 ‘Mechanism of action of Rhodiola rosea.’ The objective of this systematic review was to examine the effects of R. rosea on humans suffering from

tests are available for the assessment of cognition. However, with the completion of this systematic review, we have encountered great heterogeneity of cognitive tests across studies. In order to perform a meta-analysis of the outcome results, such heterogeneity must be eliminated. Thus, we propose the CDR computerized assessment system (Keith A. Wesnes, 2000 ) for the evaluation of the effects of guarana on cognition accompanied by the Serial of 3s and Serial of 7s tasks. The CDR battery has been found sensitive for the assessment of the cognitive effects of herbal

how science advances. The complexity of science mapping is shared by many research fields. In this article, our aim is to demonstrate the process of a systematic review based on a series of visual analytic functions implemented in the continously evolving software CiteSpace ( Chen, 2004 ; Chen, 2006 ; Chen, Ibekwe-SanJuan, & Hou, 2010 ). We demonstrate the steps of preparing a representative dataset, how to generate visualizations that can guide our review, and how to identify salient patterns at various levels of granularity. We also aim to set an example of a

issues of their relationships with heterosexual peers or the issues of sexual risk taking and sexually transmitted diseases. Although other aspects, such as social context and its effect on the association between self-concept and well-being of sexual minorities, have been researched, the literature in this area is relatively new, and findings are not homogeneous. At present, no review has been conducted using the existing literature to synthesize findings on the relationship of the two concepts: social context and self-concept. Thus, the aim of this systematic review

need for inpatient admission. To assess the relevance of clozapine associated nocturnal enuresis, the aim of this systematic review was to determine the prevalence of nocturnal enuresis secondary to clozapine use. Methods Literature search To investigate the prevalence of nocturnal enuresis in patients taking clozapine, a systematic review was conducted using the electronic data source, PubMed. The literature search was performed in March 2018. The search terms used were ‘clozapine’, ‘nocturnal enuresis’ and ‘urinary incontinence’. Those articles that could not be