Lennart de Vries, Zsuzsanna Kis and Sing-Chien Yap
Ventricular arrhythmias (VAs) in patients without structural heart disease can be found in a significant portion of the general population. The prognosis of patients with idiopathic VA is usually favorable and patients are often asymptomatic. However, sudden cardiac death (SCD) as a consequence of idiopathic VA has been reported. The aim of this review is to present an overview of the association between idiopathic VA and SCD.
Sudden cardiac death in children is one of the most devastating conditions that can be encountered in acute cardiac care. Intracardiac device therapy, providing prompt and effective treatment in malignant ventricular arrhythmia or in severe conduction abnormalities, is a promising tool to reduce the incidence of this fatal condition. However, the implementation of device-based therapy in the pediatric population is currently limited by the lack of clinical studies on large number of subjects. As a result, indications for device therapy in pediatric patients are still unclear in many circumstances. There are also several particularities related to device implantation in pediatric age, such as the somatic growth leading to a mismatch between chamber size and lead length, or the difficulties of implantation technique in children with small body weight. This study aims to present an update on the current advantages and limitations of device-based therapy for treating severe malignant arrhythmia or conduction disorders in children at risk for sudden cardiac death.
Dejan Petrović, Marina Deljanin Ilić, Bojan Ilić, Sanja Stojanović, Milovan Stojanović and Dejan Simonović
1. Zipes DP, Camm AJ, Borggrefe M, et al. ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of suddencardiacdeath – executive summary: Eur Heart J 2006;27:2099–140. https://doi.org/10.1016/j.jacc.2006.07.008
2. Loyd JD, Adams RJ, Brown TM, et al. Heart disease and stroke statistics – 2010 update: a report from the American Heart Association. Circulation 2010; 121:e46-215. https://doi.org/10.1161/CIRCULATIONAHA.109.192667
3. Gillum RF. Gographic variation in sudden coronary death
1. Centers for Disease Control and Prevention (CDC). Statespecific mortality from suddencardiacdeath - United States, 1999, MMWR Morb Mortal Wkly Rep, 2002;51:123-6.
2. Myerburg RJ, Castellanos A. Cardiac arrest and suddencardiacdeath. Braunwald E, ed. Heart Disease: A Textbook of Cardiovascular Medicine. 5th ed. Philadelphia, Pa: WB Saunders; 1997:742-779.
3. de Vreede-Swagemakers JJ, Gorgels AP, Dubois-Arbouw WI, et al. Out-of-hospital cardiac arrest in the 1990’s: a populationbased study in the
Gytis Grigaliūnas, Lina Gumbienė, Nomeda Valevičienė, Mindaugas Matačiūnas, Virgilijus Tarutis, Germanas Marinskis and Audrius Aidietis
. Arrhythmia burden in adults with surgically repaired tetralogy of Fallot: a multi-institutional study. Circulation 2010;122:868–75.
 Gatzoulis MA, Balaji S, Webber S, Siu S, Hokanson J, Poile C, et al. Risk factors for arrhythmia and suddencardiacdeath late after repair of tetralogy of Fallot: a multicentre study. Lancet 2000;356:975–81.
 Harrison DA, Harris L, Siu SC, MacLoghlin CJ, Connelly MS, Webb GD, et al. Sustained ventricular tachycardia in adult patients late after repair of tetralogy of Fallot. J Am Coll Cardiol 1997
István Adorján Szabó, Annamária Fárr, Ildikó Kocsis, Lehel Máthé, László Szilágyi and Atilla Frigy
Early repolarization pattern (ERP), a form of J-wave syndromes, was considered long time a benign ECG phenomenon. However, recent data confirmed that certain phenotypes of ERP are related to an increased risk of sudden cardiac death (idiopathic ventricular fibrillation). Our paper gives a short and practical update regarding the main issues related to ERP: epidemiological data, molecular and electrophysiological background, clinical significance and risk stratification. At the end, the future directions of research and clinical management related to ERP are presented.
D. Janusek, M. Kania, R. Zaczek, H. Zavala-Fernandez, A. Zbieć, G. Opolski and R. Maniewski
Chugh, S. S., Jui, J., Gunson, K. et al. (2004). Current burden of suddencardiacdeath: Multiple source surveillance versus retrospective death certificate-based review in a large U. S. community. Journal of the American College Cardiology , 44 (6), 1268-75.
Huikuri, H. V., Castellanos, A., Myerburg, R. J. (2001). Sudden death due to cardiac arrhythmias. New England Journal of Medicine , 345 (20), 1473-82.
Myerburg, R. J., Kessler, K. M., Castellanos, A. (1992). Sudden
Mirjana Jovanovic, Mladen Divnic, Milan Jovanovic, Sasa Babic, Katarina Nikic Djuricic and Andrea Obradovic
This paper aimed to collect and unite facts known about the effect of methadone treatment on QTc interval prolongation that could determine precipitating factors in the development of heart arrhythmias and their consequences (Torsade de Pointes and sudden cardiac death), and to raise the methadone treatment safety level.
Studies conducted up to now clearly demonstrate that methadone therapy evokes changes in the heart’s electrical conduction, but those studies also show that QTc interval prolongation could be precipitated by other factors. The most often present risk factors in our research were dose of methadone, co-medication, and co-morbidity, but other relevant risk factors were gender, age, misuse of illicit drugs, therapy length and tobacco use.
Active participation in modern treatment processes and implementation of knowledge acquired recently into daily practice, such as setting up reutilized questionnaires and diagnostic methods to expose higher risk for complications and providing broader therapeutic range for cases of drug replacement necessity, will enhance therapy safety level and bring us to the next step of resocialization of these patients, which needs to remain the final goal of treatment.
Radu Emanuil Petruse, Sergiu Batâr, Adela Cojan and Ioan Maniţiu
Chugh SS, Kelly KL, Titus JL. Suddencardiacdeath with apparently normal heart. Circulation. 2000 Aug 8;102(6):649-54.
D. Dey, V.Y. Cheng, P.J. Slomka, R. Nakazato, A. Ramesh, S. Gurudevan, G. Germano, D.S.: Automated 3-dimensional quantification of noncalcified and calcified coronary plaque from coronary CT angiography, Journal of cardiovascular computed tomography 3 (6), 372-382
Flohr T.G., Leng S., Yu L., Aiimendinger T., Bruder H., Petersilka M., Eusemann C.D., Stierstorfer K., Schmidt B., McCollough C