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, Hasegawa N. Enhancement of periodontal tissue regeneration by transplant of bone marrow mesenchymal stem cells. J Periodontal. 2004; 75(9):1281-1287. 8. L in NH, Gronthos S, Bartold PM. Stem cells and periodontal regeneration. Aust Dent J. 2008;53(2):108-112. 9. T hesleff I, Tummers M. Stem cells and tissue engineering: prospects for regenerating tissue in dental practice. Med Princ Prac. 2003;12(Suppl 1):43-50. 10. Stem Cells: Scientific Progress and Future Research Directions. Department of Health and Human Services. National Institutes of Health (NIH), Bethesda June

References 1. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282(5391):1145-1147; DOI:10.1126/SCIENCE.282.5391.1145. 2. Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep. 2015;35(2); DOI:10.1042/BSR20150025. 3. Fortier LA, Nixon AJ, Williams J, Cable CS. Isolation and chondrocytic differentiation of equine bone marrow-derived mesenchymal stem cells. Am J Vet Res. 1998;59(9):1182-1187. 4

References [1] AASEN T, RAYA A, BARRARO MJ et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nature Biotechnol 2008; 26: 1276-1284. [2] ALBERTS B, BRAY D, HOPKIN K et al. Essential Cell Biology, 2005 PWN. [3] AL-HAJJ M, CLARKE MF. Self-renewal and solid tumor stem cells. Oncogene 2004; 23: 7274-7282. [4] ALLAN DS, KEENEY M, HOWSON-JAN K et al. Number of viable CD34+ cells reinfused predicts engrafment in autologous hemopoietic stem cell transplantation. Bone Marrow Transplant 2002; 29: 967-972. [5] BARKER N, van ES

. Jiménez N, Krouwer VJD, Post JA. A new, rapid and reproducible method to obtain high quality endothelium in vitro. Cytotechnology. 2013;65:1–14; DOI:10.1007/s10616-012-9459-9. 18. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981;292:154–6. 19. Ballen KK, Gluckman E, Broxmeyer HE. Umbilical cord blood transplantation: the first 25 years and beyond. Blood. 2013;122:491–8; DOI:10.1182/blood-2013-02-453175. 20. Bielec B, Stojko R. Stem cells of umbilical blood cord - therapeutic use. Postepy Hig Med Doswiadczalnej

References 1. Wong SC. Stem cells: a personal perspective. Balkan J Med Genet. 2011; 14(2): 7-11. 2. Kelland K. British “test tube baby” pioneer Robert Edwards dies. Reuters, April 10 2013. [ edType=nl&feedName=usmorningdigest.] 3. Mole BM. Cell re-programmers Take the Nobel. The Scientist, October 8 2012. [http://] 4. Editorial. Stem cell research gets a reprieve. New York Times, January

Introduction Arguably, the stem cell revolution began with the isolation of the first embryonic stem cell lines by Sir Martin Evans (Evans and Kaufman, 1981) with the initial application to generate functional gene knockouts, which lead to significant scientific discovery [ 1 ]. The application of stem cells is one of the subjects most studied in recent years related to treating various diseases. The possibility of implementing stem cells in Parkinson’s disease, amyotrophic lateral sclerosis, spinal cord injury or stroke could revolutionize current nervous system

References 1. Ahn S.Y., Chang Y.S., Park W.S.: Mesenchymal stem cells transplantation for neuroprotection in preterm infants with severe intraventricular hemorrhage. Korean J Pediatr 57(6):251-6,2014. doi: 10.3345/kjp.2014.57.6.251. 2. Bajek A., Olkowska J., Drewa T.: Mesenchymal stem cells as a therapeutic tool in tissue and organ regeneration. Postepy Hig Med Dosw 24;65:124-32,2011. 3. Ball L.M., et al.: Multiple infusions of mesenchymal stromal cells induce sustained remission in children with steroid-refractory, grade III-IV acute graft-versus-host disease

References Abudusaimi, A., Aihemaitijiang, Y., Wang, Y.H., Cui, L., Maimaitiming, S. & Abulikemu, M. 2011. Adipose-derived stem cells enhance bone regeneration in vascular necrosis of the femoral head in the rabbit. Journal of International Medical Research, 39(5): 1852–1860. Bajek, A., Gurtowska, N., Olkowska, J., Kazmierski, L., Maj, M. & Drewa, T. 2016. Adipose-Derived Stem Cells as a Tool in Cell-Based Therapies. Archivum Immunologiae et Therapiae Experimentalis, 64(6): 443–454. Behr, B., Tang, C., Germann, G., Longaker, M.T. & Quarto, N. 2011. Locally

in connective tissue called Wharton’s jelly (WJ) and covered by epithelium [ 1 ]. In recent years, the research at preclinical and clinical levels on stem cells derived from the umbilical cord is conditioned by these cells self-renewal ability, high potential for differentiation, immuno-modulatory properties, as well as their ability to restore tissues [ 2 ]. In this article, we try to present the latest reports on the use of umbilical cord stem cells in the treatment of common autoimmune diseases,such as type I diabetes or multiple sclerosis,and also the

References Akagi S., Kaneyama K., Adachi N., Tsuneishi B., Matsukawa K., Watanabe S., Kubo M., Takahashi S. (2008). Bovine nuclear transfer using fresh cumulus cell nuclei and in vivo - or in vitro -matured cytoplasts. Cloning Stem Cells, 10 (1): 173-80. Batchelder C. A., Hoffert K. A., Bertolini M., Moyer A. L., Anderson G. B. (2004). Development of bovine nuclear transfer embryos cloned from follicular donor cells in sequential stages of differentiation. Reprod. Fertil. Dev., 16, p. 123. Batchelder C. A., Hoffert K. A., Bertolini M., Moyer A. L., Mason J. B