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References 1. Wain, S.L., Kier, R. & Vollmer, R.T. et al. (1986). Basaloid squamous carcinoma of the tongue hypopharynx and Larynx: report of 10 cases. Hum Pathol. 17, 1158-1166 2. Shanmugartnam, K. & Sobin, L.H. (1991). Histological typing of tumors of the upper respiratory tract and ear. 2nd Edition. Berlin: Springer 3. Vasudev, P., Boutross-Tadross, O. & Radhi, J. (2009). Basaloid squamous cell carcinoma: two case reports. Cases Journal. 2, 9351. DOI: 10.1186/1757-1626-2-9351 4. Wenig, M.B. (2008). Atlas of Head and Neck Pathology. 2nd Edition. Elsevier 5

66 Romanian Journal of Orthopaedic Surgery and Traumatology 2018; Special Issue 1 ROMSOS, SROA © 2018 SQUAMOUS CELL CARCINOMA DEVELOPED IN CHRONIC OSTEOMYELITIS doi: 10.2478/rojost-2018-0077 M.I. Zaharia1, A.M. Oproiu1,2, M. Costache1,2, D. Popescu1, N. Dumitrescu1, A. Varga3 1University Emergency Hospital, Bucharest, Romania 2”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 3County Emergency Hospital, Buzău, Romania Introduction. Squamous cell carcinoma is the second as frequency in malignant tumors of the skin, representing 20% of this

.R, Lee J.Y, Byun J.Y, Hong H.S, Koh E.S. - Infrasellar craniopharyngioma originating from the pterygopalatine fossa with invasion to the maxillary sinus. Br J Oral Maxillofac Surg., 2009;47(5):422-424. doi: 10.1016/j.bjoms.2008.10.003. 5. Slavin M.J, Abramson A.L. - Squamous cell carcinoma of the pterygopalatine fossa (retroantral space). J Clin Neuroophtalmol., 1986;6(4):254-257. 6. Hofstetter C.P., Singh A., Anand V.K., Kacker A., Schwartz T.H. - The endoscopic, endonasal, transmaxillary transpterygoid approach to the pterygopalatine fossa, infratemporal fossa

. The many faces of basal cell carcinoma. J Dermatol Surg Oncol 1978; 4: 23-8. Siegle RJ, MacMillan J, Pollack SV. Infiltrative basal cell carcinoma: a nonsclerosing subtype. J Dermatol Surg Oncol 1986; 12: 830-6. Clark RR, Soutar DS. Lymph node metastases from auricular squamous cell carcinoma. A systematic review and meta-analysis. J Plast Reconstr Aesthet Surg 2008; 61: 1140-7. Freedlander E, Chung FF. Squamous cell carcinoma of the pinna. Br J Plast Surg 1983; 36: 171-5.

References 1. Kásler M. Az onkológia alapjai. Medicina, Budapest, 2011;327-386. 2. Stewart B. W., Wild C. P. World Cancer Report. International Agency for Research on Cancer, Lyon 2014;422-431. 3. Gregoire V, Lefebve JL, Licitra A et al. Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow up. Ann Oncol, 2010;21(suppl 5): v184-186. 4. National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: head and neck cancers. Version 2.2013 5. Psyrri A, Rampias T, Vermorken

References Marjolin JN. Dictionnaire de medicine, 1828;1:31-50. Fleming MD, Hunt JL, Purdue GF, Sandstad J. Marjolin 's Ulcer: a review and revaluation of a difficult problem. J Burn Care Rehabil, 1990;11:460-69. DaCosta JC. Carcinomatous changes in the area of chronic ulceration or Marjolin's ulcer. Ann Surg, 1903; 37:496-502. Noona KJ Goetz DD, Marsh JL, Peterson KK. Rapidly destructive squamous cell carcinoma as a complication of chronic osteomyelitis: A case report and review of literature. The IOWA Orthop Journal. 1991;11:165-70. Yang D, Morrison BD

reassessment after 212 cases. Head Neck 2011; 33 : 1154-61. Hug EB, Wang CC, Montgomery WW, Goodman ML. Management of inverted papilloma of the nasal cavity and paranasal sinuses: importance of radiation therapy. Int J Radiat Oncol Biol Phys 1993; 26 : 67-72. Gomez JA, Mendenhall WM, Tannehill SP, Stringer SP, Cassisi NJ. Radiation therapy in inverted papillomas of the nasal cavity and paranasal sinuses. Am J Otolaryngol 2000; 21 : 174-8. Tanvetyanon T, Qin D, Padhya T, Kapoor R, McCaffrey J, Trotti A. Survival outcomes of squamous cell carcinoma arising from

increase the proportion of hypoxic tumour cells. 13 Hypoxia is widely recognized as a major factor leading to the resistance of tumour cells to radiotherapy, but several mechanisms may also cause cells in the hypoxic region to be resistant to anticancer drugs. 16 The influence of anaemia on the outcome of treatment was first recognized in 1940s in cervical cancer patients and later in patients with other tumours such as head and neck squamous cell carcinoma, carcinoma of the lungs, bladder, prostate and anus. 7 , 17 , 18 The purpose of present study was to evaluate

are present in surgical margins of oral squamous cell carcinoma. JBUON, 2018;23:1686-1692. 24. Mancic L, Djukic-Vukovic A, Dinic I, Nikolic MG, Rabasovic MD, Krmpot AJ, et al. NIR photo-driven upconversion in NaYF4:Yb,Er/PLGA particles for in vitro bioimaging of cancer cells. Mater Sci Eng C, 2018;91:597-605. 25. Repetto G, del Peso A, Zurita JL. Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat Protoc, 2008;3:1125-1131. 26. De Oliveira PF, Alves JM, Damasceno JL, Oliveira RAM, Júnior Dias H, Crotti AEM, et al. Cytotoxicity screening of

Introduction Head and neck squamous cell carcinoma (HNSCC) is a common malignancy that ranks sixth in incidence of all cancers. The HNSCC tumors display dysregulation of cell differentiation, cell cycle control, epithelial and stromal interactions, apoptosis, angiogenesis and their associated pathways [ 1 , 2 ]. Although its exact cause remains unclear, like most malignancies, HNSCC pathogenesis is affected by both genetic and environmental factors [ 1 ]. Of the approximately 500,000 new cases of HNSCC each year, many occur in the oral cavity, pharynx, and larynx