Allergic diseases represent an important health problem in the most of developed countries, due to continuous increasing prevalence, with significant individual and social consequences. Allergic diseases may raise serious problems in clinical practice, derived from complexity of clinical forms and mechanisms and from rising incidence of severe cases, with high fatality risk. Taking into consideration the dramatic increase of all allergies forms during the last decades, they are considered a real “epidemic” of the XXIst century, being classified by the World Health Organization as the fourth most frequent chronic diseases. The European authorities pay more attention to allergic diseases in last years and discuss the actual situation of the allergology specialty in different countries, with the aim of harmonization and improvement of medical assistance in this field. The aim of this paper is presentation of some relevant aspects of allergology specialty and practice in our country in the actual European context, mainly unmet needs and difficulties, taking into consideration recommendations and priorities recently issued by European authorities. We hope for a better recognition of the specialty and improved interdisciplinary collaboration.
Bozeman, B., Rimes, H., Youtie, J. (2015). The evolving state-of-the-art in technology transfer research: Revisiting the contingent effectiveness model, Research Policy , 44(1), 34-49.
Dezvoltarea capacității de transfer și comercializare a rezultatelor din cercetare în cadrul institutelor și centrelor de cercetare aplicativă din România – implementarea unui model pilot pentru compartimentele de specialitate, Contract de tip Proiect Sectorial , 10S/04.02.2015 (in Romanian).
Voichiţa Ileana Sîrbu, Irina Pintilie and Mihaela M. Opriş
Venous thromboembolism (VTE) is a multifactorial disease; age, a prior history of deep vein thrombosis, cancer, surgery, obesity, prolonged immobility, pregnancy, oral contraceptive agents, thrombophilia, have been identified as major risk factors. Thrombophilia is a heritable or acquired prothrombotic state that increases the tendency to venous thromboembolism. The use of anabolic steroids is strongly linked to venous thromboembolism, due to their role in thrombus formation. We present a case of a venous thromboembolism in a 26-year old male who had undergone a testosterone abuse and had a previously undiagnosed genetic thrombophilia, with discussion upon literature regarding the heritable thrombophilia and prothrombotic effects of testosterone.
: Editura Fundaţiei Universitare Dunărea de Jos, Galaţi.
Dibuz, Erzsébet. 2014. Magyar gyümölcsfajták elnevezésének története és gyakorlata. In: Soltész, Miklós (ed.), Magyar gyümölcsfajták. Budapest: Mezőgazda Kiadó. 35-63.
Nagy, Imola Katalin. 2013. The usage and translation of plant names. In: Munteanu, Sonia-Bretan, Bianca (eds), Diversitate culturală şi limbaje de specialitate, Casa Cărţii de Ştiintă, Cluj. 119-129.
Nagy-Tóth, Ferenc. 1998. Régi magyar gyümölcsfajták. Kolozsvár: Erdélyi Múzeum-Egyesület Kiadó
Florina Ruţa, Oana Maria Iacob, Cristina Naşca and Anca Ileana Sin
). Analiza de situație în cadrul campaniei cu ocazia zilei naționale fără tutun .
Trofor, A., Mihălțan, M., & Mihăițan, S. (2010). Ghid de renunțare la fumat și asistență de specialitate a fumătorului (GREFA). Ghidul Societății Române de Pneumologie, Ediția a 2-a , București: Tehnopress, ISBN 978-973-702-768-9.
Iuliu C. Ivanov, Daniela Jitam, Georgiana E. Grigore, Mihaela Zlei, Anca V. Ivanov, Silvia Dumitraş, Eugen Carasevici and Ingritli C. Miron
Background. A high occurrence of translocation t(4;11)(q21;q23) was reported in infant acute lymphoblastic leukemia (ALL) leading to the fusion of the mixed lineage leukemia (MLL) gene on chromosome 11 and the AF4 gene on chromosome 4. More than 50 distinct MLL-AF4 types of fusion have been previously identified, none of those reported matching the peculiarities found in an infant ALL case to be reported below. Materials and methods. Molecular tests were performed for the detection of TEL-AML1, BCR-ABL(p190), E2A-PBX1, and MLL-AF4 in the peripheral blood sample of a 21 days new-born boy suspected of ALL. An unexpected MLL-AF4 fragment was identified, further purified, and later analyzed by sequencing. Flow cytometry analyses were carried out at diagnosis and relapse on a FACSCanto-II cytometer (Becton-Dickinson). Results. The patient was found to be positive for the MLL-AF4 transcript, with an uncommonly long-sized product and a previously undescribed sequence (in-frame fusion between exon 12 of MLL and exon 4 of the AF4 gene). The immunophenotypic analyses also showed a particular development: while at diagnosis a dominant malignant clone displaying a B lymphoid precursor phenotype was described, at relapse a malignant monocytoid population predominantly expanded. The presence of MLL-AF4 e12-e4 transcript was still manifest at relapse, without other transcript characteristic for myeloid lineage. Conclusions. To our knowledge, this is the first report of a MLL-AF4 rearrangement revealing this complex transcript with new breakpoints in MLL. Its early detection may predict an immunophenotypic switch and may assist the clinicians in designing optimized therapies.
Corina Roman-Filip, Aurelian Ungureanu, Dan Filip, Eugen Radu and Ioan-Sorin Zaharie
Creutzfeldt - Jakob disease (CJD) is a rare neurodegenerative disease caused by prions, characterized by a progressive dementia with rapid onset, psychiatric and neurologic symptoms (myoclonus, cerebellar, pyramidal, extrapyramidal and visual signs), with an invariable course to exitus. There are three general forms: sporadic or spontaneous, genetic or familial, and acquired form, including a variant form of CJD. The diagnosis can be confirmed only by histological examination of brain tissue, showing non-inflammatory spongiform changes and neuronal loss. We present the case of a 64 years old male who was admitted in our department for a rapidly progressive cognitive decline, hallucinations and myoclonus. Autopsy brain histology confirmed the diagnosis showing incipient spongiform vacuolization and astrogliosis. This paper illustrates a very rapid course of a sporadic CJD with discussion upon literature regarding the laboratory and pathology biomarkers of diagnosis.
This paper presents an analysis of the flow regime of the Timiş River in Romania. The analysis was based on hydrological data provided by the National Institute of Hydrology and Water Management in specialized publications (hydrological yearbooks or online series). The data were supplemented by personal observations in the field. The following leakage parameters were analyzed: average flow (monthly, seasonal, annual), maximum flow (especially flash floods) and minimum leakage. This paper highlights the link between hydrological parameters and conditioning factors of spatial distribution (characteristics of the geological substratum, relief units, elevation, slope) and temporal variation of flow (in function of type of supply, and variability and variation of climatic conditions).
Emese Rita Markovics, Kinga Jánosi, Carmen Biriș, Diana Cerghizan, C Horga, B Bögözi and Alina Iacob
1. Samorodnitzky-Naveh GR, Geiger SB. Patient’s satisfaction with dental esthetics. JADA. 2007;138(6):805-808.
2. Bîclesanu C, Valeriu I, Pangică A. Importanța esteticii în restaurarea funcției fizionomice a pacientului. Revista Română de Stomatologie. 2007; LIII(4):176-180.
3. Petre A, Ionită S, Trăistaru T. Criteriile estetice in medicina dentara consemnate in literatura de specialitate. Revista Română de Stomatologie. 2011;LVII(4):278-286.
4. Tin-Oo M, Saddki N, Hassan N