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Pathophysiological response to experimental oral overdose of different forms of selenium in lambs

gestation and lactation. J. Anim. Sci., 84: 660-668. Davis P.A., Mc Dowell L.R., Wilkinson N.S., Buergelt C.D., Van Alstyne R., Wel-don R.N., Marshall T.T., Matsuda- Fugisaki E.Y. (2008). Comparative effects of various dietary levels of Se as sodium selenite or Se yeast on blood, wool, and tissue Se concentrations of wether sheep. Small Rumin. Res., 74: 149-158. Davis T.Z., Stegelmeier B.L., Green B.T., Welch K.D., Hall J.O. (2013). Evaluation of the respiratory elimination kinetics of selenite and Se-methylselenocysteine after oral

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Different experimental approaches in modelling cataractogenesis

perspective from in vitro and lens culture studies. Exp Eye Res   65 : 507-516. Dillon J, Roy D, Spector A, Walker ML, Hibbard LB and Borkman RF. (1989). UV laser photodamage to whole lenses. Exp Eye Res   49 : 959-966. Doganay S, Borazan M, Iraz M and Cigremis Y. (2006). The effect of resveratrol in experimental cataract model formed by sodium selenite. Curr Eye Res   31 : 147-153. Doganay S, Turkoz Y, Evereklioglu C, Er H, Bozaran M and Ozerol E. (2002). Use of caffeic acid phenethyl ester

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Antioxidants and selenocompounds inhibit 3,5-dimethylaminophenol toxicity to human urothelial cells

isolated rat pancreatic islets function by combination of cerium oxide nanoparticles/sodium selenite through reduction of oxidative stress. Toxicol Mech Methods. 2012;22:476-82. doi: 10.3109/15376516.2012.673093. 24. Mansur DB, Hao H, Gladyshev VN, Korotkov KV, Hu Y, Moustafa ME, El-Saadani MA, Carlson BA, Hatfield DL, Diamond AM. Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines. Biochem Pharmacol 2000;60:489-97. PubMed PMID: 10874123. 25. Fontenelle LS, Feitosa MM, Silva Morais JB, Soares

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Influence of Selenium on the Morphology of Immune System Organs in Healthy Broilers

parameters of broilers reared under thermoneutral or heat stress conditions. Int J Biometeorol 2014, 58:741-752. 5. Todorović M, Jovanović M, Jokić Ž, Hristov S, Davidović V: Alterations in liver and kidneys of chickens fed with high levels of sodium selenite or selenized yeast Acta Veterinaria-Beograd, 2004, 54(2-3):191-200. 6. Biswas A, Mohan J, Sastry KVH: Effect of higher levels of dietary selenium on production performance and immune responses in growing Japanese quail. Br. Poult Sci 2006, 47:511-515. 7. Franson JC, Hoffman DJ, Wells-Berlin A, Perry

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The influence of high selenium intake of ewes on leukocytes in newborn lambs

blood of pygmy goats from herd infected with Mycobacterium avium subspecies paratuberculosis. Vet Med Czech 44: 259-262. Hawkes WC, Turek P (2001): Effect of dietary selenium on sperm motility in healthy men. J Androl 22: 764-772. Johnson VJ, Tsunoda M, Sharma RP (2000): Increased production of proinflammatory cytokines by murine macrophages following oral exposure to sodium selenite but not to seleno-L-methionine. Arch Environ Con Tox 39: 243-250. Kantola M, Vartiainen T (2001): Changes in selenium, zinc, copper and

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Comparison of the influence of selenium supplementation in organic and inorganic forms on oxidant/antioxidant balance in rat lungs

References 1. Amara I.B., Soudani N., Troudi A., Hakim A., Zeghal K.M., Boudawara T., Zeghal N.: Dimethoate induced oxidative damage and histopathological changes in lung of adult rats: modulatory effects of selenium and/or vitamin E. Biomed Environ Sci 2012, 25 , 340-351. 2. Bik D.: Effect of sodium selenite injection on selenium and magnesium concentrations in the blood serum of ewes and their offspring. Bull Vet Inst Pulawy 1999, 43 , 185-190. 3. Bradford M.M.: A rapid and sensitive method for the

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Protective Role of Selenium Against Over-Expression of Cancer-Related Apoptotic Genes Induced By O-Cresol in Rats

(KDRGCAMS). Observations on effect of sodium selenite in prevention of Keshan disease. Chin Med J 1979;92:471-6. Khalil WKB, Abd El- Kader HAM, Eshak MG, Farag IM, Ghanem KZ. Biological studies on the protective role of artichoke and green pepper against potential toxic effect of thermally oxidized oil in mice. Arab J Biotech 2009;12:27-40. NTP Report on the Toxicity Studies of Cresols (CAS Nos. 95- 48-7, 108-39-4, 106-44-5) in F344/N Rats and B6C3F1 Mice (Feed Studies). Toxicity Report Series No. 9. U.S. Department of

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Phenotypic and genotypic variations in Candida albicans isolates from Romanian patients


Background: During the last two decades a major increase in the proportion of severe fungal infections has been noted due to the excessive use of broad-spectrum antibiotics, catheters, and a growing number of immunocompromised patients.

Objectives: This is the first investigation providing complete data regarding the phenotypic and genotypic profiles of Candida albicans (C. albicans) isolates in Romanian patients.

Methods: We investigated 301 isolates in terms of genotype determination (G), resistogram (R), phospholipase activity (Pl), haemolysis (Hl), proteinase activity (Pt), and biofilm formation (BF).

Results: The analyzed isolates of C. albicans showed low values for Pt (61.73%), Hl (95.49%), and BF (60.71%), and did not present any Pl activity (92.23%). More than half of the investigated samples were genotype A with 450 bp (52.92%) and the majority (86.19%) were resistant to sodium selenite (A), boric acid (B), sodium periodate (D) and silver nitrate (E), but sensitive to cetrimide (-). One-way ANOVA analysis revealed significant effects of the infection site on biofilm formation (p = 0.0137) and no significant correlation was found between the genotype (A, B, C) and the infection site (p =0.449).

Conclusions: Based on the obtained results it can be concluded that C. albicans isolates in Romanian patients exhibit different genotypic and phenotypic patterns, and no significant correlations between genotype and infection site could be observed.

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Alleviation Effect of Selenium on Manganese Stress of Plants


Mn, as Fe, Zn, Cu and Ni is a heavy metal and also a necessary element all the living organisms. Excessive Mn nutrition causes a strong oxidative stress. The aim of the studies was to determination the effect of Se treatment (as sodium selenite Na2O4Se3) to alleviate the Mn stress of plants. Because of its sensitivity to oxidative stress induced by excessive concentrations of Mn a model plant was lettuce (Lactuca sativa L. ‘Sunny’). The studies were conducted in a controlled environment growth room in stable climate conditions: 16 h photoperiod; temperature light/dark 18.0 ±0.5°C/16.0 ±0.5°C; relative humidity 70-80%; quantum flux density 195-205 μmol m−2 s−1. Plants were grown hydroponically in nutrient solution characterized by excessive Mn content (19.2 mg dm−3) and different contents of Se (control; 0.77, 1.05, 1.33 mg dm−3). In all the combination were also tested different foliar sprays (distilled water and a 0.005% Se solution). Plants grown under conditions described above take up and transported Se from nutrient solutions into their leaves with a significant reduction of Mn concentration and changes in the plant nutrient status. With the increase in the concentrations of Se clearly narrowed quantitative relations in the leaves between this element and micro-metallic. Increasing Se levels in nutrient solution has a positive influence on the growth of plants, but Se foliar treatment generally decreases plant yield. The study shown that Se application may lead to alleviation of Mn stress of plants, with simultaneous reduce in Mn concentration in leaves - which may be of practical importance also in the cultivation of more economically important species.

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Supplemental Selenium Reduces the Levels of Biomarkers of Oxidative and General Stress in Peripartum Dairy Cows / Dodati Selen Snižava Nivoe Biomarkera Oksidativnog I Opšteg Stresa Kod Mlečnih Krava U Peripartalnom Periodu

The aim of this investigation was to determine the influence of oxidative stress upon general stress in dairy cows on parturition and whether the indicators of stress can be reduced by selenium (Se) supplementation.

A total of 36 animals were divided into 3 groups 21 days prepartum and treated with a single-term intramuscular supplement of sodium selenite: Control group - 0 mg; group Se10 - 10 mg; group Se20 - 20 mg.

Se supplementation significantly raised blood Se content and glutathione peroxidase (GPx) activity in groups Se10 and Se20, compared to Control, although there was no marked difference between supplemented groups. Plasma malondialdehyde (MDA) and cortisol concentrations were significantly reduced in supplemented groups Se10 and Se20, compared to Control. A negative correlation was detected between blood GPx activity and plasma MDA, while a positive correlation was determined between plasma MDA and cortisol concentrations.

These results indicate that prepartum Se supplementation can be utilized for a partial relief of stress in cows during labor by augmenting the antioxidative action of GPx.

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