Search Results

1 - 10 of 28 items :

  • "severe mental illness" x
Clear All


Background: Forensic autopsy strategies may improve differential diagnostics both post-mortem and ante-mortem and aid in clinical settings concerning preventive efforts for premature mortality. Excess mortality and reduced life expectancy affect persons with severe mental illnesses (SMI) for multi-faceted reasons that remain controversial. Somatic conditions, medical treatment and lifestyle diseases, which are primarily examined in the living, contribute to premature deaths. The underlying pathophysiological mechanisms are unclear, though, and the benefits of a focused, standardised autopsy remain unproven. We have developed and implemented an optimised molecular–biological autopsy for deceased persons with SMI. Our aim is to map the occurrence of 1) somatic diseases and organ changes; 2) metabolic syndrome; 3) use and abuse of alcohol, pharmaceuticals and psychoactive substances; 4) pharmacokinetic and pharmacodynamic factors in the metabolism of pharmaceuticals; and 5) genetic variations (acquired and/or congenital) in sudden cardiac death. Additionally, we hope to contribute to diagnostic treatments and preventive measures to benefit those living with SMI. Methods: SURVIVE: let the dead help the living is a prospective, autopsy-based study on 500 deceased persons with SMI subjected to forensic autopsies under the Danish Act on Forensic Inquests and Autopsy. The autopsies followed an extended, standardised autopsy protocol comprised of whole-body computed tomography scanning, magnetic resonance imaging of the heart and brain and an extended forensic autopsy, including a wide panel of analyses (toxicology, microbiology, genetics, histology and biochemical analysis). Additionally, post-mortem data were linked to ante-mortem health data extracted from Danish national health registers.

Discussion: The SURVIVE autopsy procedure, including tissue sampling and bio banking, has been shown to be effective. We expect that the SURVIVE study will provide unique opportunities to unravel the mechanisms and causes of premature death in persons with SMI. We also expect that identifying prognostic biomarkers for comorbidities will contribute to prevention of premature deaths and comorbidities in persons with SMI.

cardiometabolic risk in people with schizophrenia and other severe mental illnesses. Lancet Psychiatry 2: 452-464, 2015 5. De Hert M, Schreurs V, Vancampfort D, van Winkel R . Metabolic syndrome in people with schizophrenia: a review. World Psychiatry 8: 15–22, 2009. 6. Mitchell AJ, Vancampfort D, Sweers K et al . Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders – a systematic review and meta-analysis. Schizophr Bull 39: 306–318, 2013. 7. Vancampfort D, Vansteelandt K, Correll CU et al . Metabolic syndrome and metabolic

. Hyperlipidemia following treatment with antipsychotic medications. Am J Psychiatry 2006; 163:1821–1825. 41. Raedler TJ. Cardiovascular aspects of antipsychotics. Curr Opin Psychiatry. 2010;23(6):574-81. 42. Brown S. Excess mortality of schizophrenia: a meta-analysis. Br J Psychiatry 1997; 171:502–508. 43. Ray WA, Chung CP, Murray KT, et al. Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 2009; 360:225–235. 44. Newcomer JW, Hennekens CH. Severe mental illness and risk of cardiovascular disease. JAMA 2007; 298:1794–1796. 45. Newcomer JW

Introduction Madness, in simple terms, can be defined as a state of severe mental illness ( Merriam-Webster 2017 ). Mental illness, according to the American Psychiatric Association, can be described as a health condition involving changes in thinking, emotion or behaviour (or a combination of these) ( American Psychiatric Association 2017 ). The etiological/risk factors of mental illness are diverse ( Cirulli et al 2009 ). However, the major factors include developmental stress, substance abuse, and nutritional factors ( Dube et al., 2003 , Cirulli et al., 2009

, Mondelli V. The dietary pattern of patients with schizophrenia: a systematic review. Journal of psychiatric research. 2013;47:197–207. 14. Teasdale S, Samaras K, Wade T, Jarman R, Ward P. A review of the nutritional challenges experienced by people living with severe mental illness: a role for dietitians in addressing physical health gaps. Journal of human nutrition and dietetics. 2017;30:545–53.

. 35:1947-1952. Srivastava S., O.P.John, S.D.Gosling, J.Potter (2003) Development of personality in early and middle adulthood: Set like plaster or persistent change? J.Pers.Soc.Psychol., 84:1041-1053. Stobble J., N.C.R.Mulder, B.J.Roosenschoon, M.Depla, H.Kroon (2010) Assertive community treatment for elderly people with severe mental illness. BMC Psychiatry. 10:84. McCrae R.R. (1993) Moderated Analyses of Longitudinal Personality Stability. J.Pers.Soc.Psychol., 65:577–585. Rowe J.W., R.L.Kahn (1997) Successful

Residential Care Journal. 2001; 5:97-111. 14. Skantze K, Malm U, Dencker S, et al. Comparison of quality of life with standard of living in schizophrenic outpatients. Br J Psychiatry. 2002; 161: 797-801. 15. Lehman A. Measures of quality of life among persons with severe and persistent mental disorders. Soc Psychiatry Psychiatr Epidemiol. 2006; 31:78-88. 16. Lehman A, Kerman E, DeForge B, et al. Effects of homelessness on the quality of life of persons with severe mental illness. Psychiatr Serv. 2005; 46:922-925. 17. Test MA, Greenberg JS, Long JD, Brekke JS, Burke SS

pacjentów ze schizofrenią. Psychiatria i Psychologia Kliniczna,2013, 13(1). 26. Yıldırım A., Hacıhasanoğlu Aşılar R., Camcıoğlu T. H., Erdiman S., Karaağaç E. Effect of Psychosocial Skills Training on Disease Symptoms, Insight, Internalized Stigmatization, and Social Functioning in Patients with Schizophrenia. Rehabilitation Nursing , 2015, 40 (6), 341-348. 27. Hasson-Ohayon I., Kravetz S., Meir T., Rozencwaig S. Insight into severe mental illness, hope, and quality of life of persons with schizophrenia and schizoaffective disorders. Psychiatry Res. 2009; 167: 231

Social-Environmental Context of Violent Behavior in Persons Treated for Severe Mental Illness’, American Journal of Public Health 92(9): 1523-1531. Walsh, E. & Fahy, T. (2002) ‘Violence in Society: Contribution of Mental Illness is Low’, British Medical Journal 325: 507-508.

(2), 179-193. Topor, A., Svensson, J., Bjerke, C., Borg, M. & Kufås, E. (2002). Vendepunkter - Et nærstudie af vendepunkter for mennesker der er kommet sig efter alvorlig psykisk lidelse /Turning-points - a study of turning-points for people recovered from severe mental illness/. Copenhagen: Videnscenter for socialpsykiatri. Topor, A., Borg, M., Di Girolamo, S. & Davidson, L. (2011). Not Just an Individual Journey: Social Aspects of Recovery. International Journal of Social Psychiatry, 57(1), 90-99 Tew, J., Ramon, S., Slade, M., Bird, V., Melton, J. & Le Boutillier, C