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the soluble fms-like tyrosine kinase-1/placental growth factor ratio as a diagnostic test for preeclampsia. Hypertension 2014;63(2):346-52. 11. Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennstr M, et al. Predictive value of the sFlt-1: PlGF ratio in women with suspected preeclampsia. N Engl J Med. 2016;374(1):13-22.

gestation ( 26 ). Navaratnam and colleagues went a step further, and compared PlGF tests and the sFlt-1/PlGF ratio with abnormal uterine artery Doppler ( 27 ). Results of their investigation showed significant association between PlGF or sFlt-1/PlGF ratio with results of Doppler parameters. Taken all together, uterine artery Doppler can be used for prediction and monitoring of preeclampsia, but in order to increase sensitivity and specificity uterine artery Doppler should be combined with estimation of other markers. ROLE OF MICRO-RNA IN PREECLAMPSIA Ribonucleic acid (RNA