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In Vivo Enzymes Activities of Some Ru(II) Compounds with N-Alkylphenothiazines

References 1. Alessio E: Synthesis and reactivity of Ru-, Os-, Rh-, and Ir-Halide−Sulfoxide complexes. Chem Rev 2004, 104: 4203-4242. 2. Kandioler W, Hartinger CG, Nazarov AA, Kasser J, John R, Jakupec MA, Arion VB, Dyson PJ, Keppler BK: Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety. J Organomet Chem 2009, 694: 922-929. 3. Singh AK, Pandey DS, Xu Q, Braunstein P: Recent advances in supramolecular and biological aspects of arene ruthenium

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Ruthenium(II) Complexes as Potential Apoptosis Inducers in Cancer Therapy

, lipophilicity and anticancer activity. J BiolInorg Chem. 2017;22(7):1007-28. 10. Urathamakul T, Beck JL, Sheil MM, Aldrich-Wright JR, Ralph SF. A mass spectrometric investigation of noncovalent interactions between ruthenium complexes and DNA. Dalton Trans. 2004;(17):2683-90. 11. Alessio E, Mestroni G, Bergamo A, Sava G. Ruthenium antimetastatic agents. Curr Top Med Chem. 2004;4(15):1525-35. 12. Coverdale JP, Laroiya-McCarron T, Romero-Canelón I. Designing Ruthenium Anticancer Drugs: What Have We Learnt from the Key Drug Candidates?. Inorganics. 2019

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Toxic Effects of Metallopharmaceuticals

. Keppler BK, Henn M, Juhl U M, Berger MR, Niebl R, & Wagner FE. (1989). New ruthenium complexes for the treatment of cancer. In Baulieu E, Forman DT, Ingelman- Sundberg M, Jaenicke L, Kellen JA, Nagai Y, Springer GF, Trager T, Will-Shahab L,Wittliff JL (Eds.) Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy (pp. 41-69). Springer Berlin Heidelberg. 17. Meijer C, de Vries EG, Marmiroli P, Tredici G, Frattola L, & Cavaletti G. (1999). Cisplatin-induced DNA-platination in experimental dorsal root ganglia neuronopathy. Neurotoxicology

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Cytotoxic and Genotoxic Effects of the Quercetin/Lanthanum Complex on Human Cervical Carcinoma Cells In Vitro

cell line by lanthanum chloride. Biol Trace Elem Res 2011. DOI: 10.1007/s12011-011-9027-8 Kovacic P, Popp WJ, Ames JR, Ryan MD. Anti-cancer action of metal complexes:electron transfer and oxidative stress? Anticancer Drug Des 1988;3:205-16. Kostova I, Momekov G, Zaharieva M, Karaivanova M. Cytotoxic activity of new lanthanum (III) complexes of biscoumarins. Eur J Med Chem 2005;40:542-51. Brabec V, Nováková O. DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity

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Carbon Sequestration: Hydrogenation of CO2 to Formic Acid

, Russ. Chem. Bull. , 51, 2165–2169 (2002). 24. Gao Y., Kuncheria J. K., Jenkins H. A., Puddephatt R. J. and Yap G. P. A., The interconversion of formic acid and hydrogen/carbon dioxide using a binuclear ruthenium complex catalyst, J. Chem. Soc., Dalton Trans ., 3212–3217 (2000). 25. Tai C. C., Pitts J., Linehan J. C., Main A. D., Munshi P. and Jessop P. G., In situ formateion of ruthenium catalysts for the homogeneous hydrogenation of carbon dioxide. Inorg. Chem. , 41, 1606–1614 (2002). 26. Man M. L., Zhou Z. Y., Ng S. M. and Lau C. P

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Ionic [Ru] complex with recyclability by electro-adsorption for efficient catalytic transfer hydrogenation of aryl ketones

ofruthenium after solid phase extraction with somequinoxaline dyes into microcrystalline p -dichlorobenzene. Spectrochim. Acta Part. A . 58, 1831–1837. DOI: 10.1016/S1386-1425(01)00681-3. 24. Chaplin, A.B., Fellay, C., Laurenczy, G. & Dyson, P.J. (2007). Mechanistic Studies on the Formation of η 2 -Diphosphine(η 6 - p -cymene)ruthenium(II) Compounds. Organometallics 26, 586–593. DOI: 10.1021/om060752n. 25. Gichumbi, J.M., Friedrich, H.B. & Omondi, B. (2016). Synthesis and characterization of half-sandwich ruthenium complexes with N-alkyl pyridyl

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Biological evaluation of transdichloridoplatinum( II) complexes with 3- and 4-acetylpyridine in comparison to cisplatin

2002; 42: 317-25. 4. Reedijk J. Metal-ligand exchange kinetics in platinum and ruthenium complexes. Platinum Metals Rev 2008; 52: 2-11. 5. Wang, X. Fresh platinum complexes with promising antitumor activity. Anti- Cancer Agents Med Chem 2010; 10: 396-411. 6. Farrell N, Kelland LR, Robert JD. Van Beusichem M. Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their

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Measuring plasma ferritin levels with two different methods: A comparison of roche cobas E601 versus roche cobas C501 (integrated modular system roche cobas 6000)

expanded particle surface immunoturbidimetric test. Precipitation was to be turbidimetric at 570/800 nm. Cobas e601 hormone module measurement method First incubation: sample with monoclonal antibody with biotin specific to ferritin and monoclonal antibody specific to ferritin marked with ruthenium complex creates a sandwich complex. Second incubation: After streptavidin-covered micro-particles are added, by way of interaction between biotin and streptavidin, complex is linked to a solid phase. Reaction mixture is aspired into measurement cell where micro

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Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy

emerging as a new class of promising anticancer drugs. They show selective activity against certain cancer cells and low toxicity. Due to octahedral coordination sphere, ruthenium complexes have higher degree of specificity and size discrimination and exert lower toxicity and faster elimination from the body, in contrast to square planar geometry of platinum (II) compounds. Well known species NAMI-A and KP1019, which are currently in clinical trials, is opening new approaches in cancer treatment. The cellular targets of ruthenium compounds have not yet been identified

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