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References 1. Aydin S, Aksoy A, Aydin S et al. Today's and yesterday's of pathophysiology: biochemistry of metabolic syndrome and animal models. Nutrition 30: 1-9, 2014. 2. Ghezzi AC, Cambi LT, Botezelli JD, Ribeiro C, Dalia RA, Rostom de Mell MA. Metabolic syndrome markers in Wistar rats of different ages. Diabetol Metab Syndr 4: 16, 2012. 3. Santoro N, Weiss R. Metabolic syndrome in youth: current insights and novel serum biomarkers. Biomark Med 6: 719-727, 2012. 4. Abdulla MH, Sattar MA, Abdullah NA, Hye Khan MA, Anand Swarup KR, Johns EJ. The contribution of

Necrosis. Alternative Protocol 2. Detection of DNA fragmentation in Total Genomic DNA. In: Current Protocols in Toxicology . Costa LG, Hodgson E, Lawrence DA, Reed DJ, Greenlee WF (eds), John Wiley & Sons Inc. Somerset, pp 2759, 2005. 15. Kovalenko VM, Bagnyukova TV, Sergienko OV et al. Epigenetic changes in the rat livers induced by pyrazinamide treatment. Toxicology and Applied Pharmacology 225: 293-299, 2007 16. Ni S, Wang X, Wang J, Zhao Z, Zeng S. The Effects of a high-fat and high-energy diet on the hepatic expression of CYP3A in developing female rats

References 1. Barone J.J., Roberts H.R.: Caffeine consumption. Food Chem Toxic 1996, 34, 119-129. 2. Birkner E., Grucka-Mamaczar E., Żwirska-Korczala K., Zalejska-Fiolka J., Stawiarska-Pięta B., Kasperczyk S., Kasperczyk A.: Influence of sodium fluoride and caffeine on the kidney function and free-radical processes in that organ in adult rats. Biol Trace Elem Res 2006, 109, 35-47. 3. Birkner E., Grucka-Mamaczar E., Żwirska-Korczala K., Zalejska-Fiolka J., Stawiarska-Pięta B., Kasperczyk S., Kasperczyk A.: Influence of sodium fluoride and caffeine on the

glucose homeostasis. Int J Obes (Lond) 2017;41:1413-9. doi: 10.1038/ijo.2017.123 8. Milić M, Žunec S, Micek V, Kašuba V, Mikolić A, Lovaković BT, Semren TŽ, Pavičić I, Marjanović Čermak AM, Pizent A, Lucić Vrdoljak A, Valencia-Quintana R, Sánchez-Alarcón J, Želježić D. Oxidative stress, cholinesterase activity, and DNA damage in the liver, whole blood, and plasma of Wistar rats following a 28-day exposure to glyphosate. Arh Hig Rada Toksikol 2018;69:154-68. doi: 10.2478/aiht-2018-69-3114 9. Pohanka M. Inhibitors of acetylcholinesterase and butyrylcholinesterase meet

.Physiol. 1954, 178,505-9; 8. McArdle W.D., Moutoye H.J. Reliability of exhaustive Swimming in the laboratory rat. J.Appl.Physiol. 1966,21,1431-4; 9. Jarrett A.S. Alveoral carbon dioxide tension at increased ambient pressures. J.Appl. Physiol. ,1966, 21,158-62; 10. Ryłowa M.Ł. Mietody issledowanja chroniczeskogo diejstwe wrodnych faktorow sredy w eksperymencie. Medicins, Moskwa, 1964; 11. Terblanche, S. E. The Effects of Exhaustive Exercise on the Activity Levels of Catalase in Various Tissues of Male and Female Rats. Cell Biology International, 1999, 23: 749-753. DOI: 10

References Abel S., Gelderblom W.C. (1998). Oxidative damage and fumonisin B1-induced toxicity in primary rat hepatocytes and rat liver in vivo . Toxicology, 131: 121–131. Álvarez-Lloret P., Lind P.M., Nyberg I., Orberg J., Rodríguez-Navarro A.B. (2009). Effects of 3,3',4,4',5-pentachlorobiphenyl (PCB126) on vertebral bone mineralization and on thyroxin and vitamin D levels in Sprague-Dawley rats. Toxicol. Lett., 187: 63–68. Antonissen G., Croubels S., Pasmans F., Ducatelle R., Eeckhaut V., Devree-se M., Verlinden M., Haesebrouck F., Eeckhout M., De Saeger S

References 1. Alexander B.T., Llinas M.T., Kruckeberg W.C., Granger J.P.: L-arginine attenuates hypertension in pregnant rats with reduced uterine perfusion pressure. Hypertension 2004, 43 , 832-836. 2. Chae I.H., Park K.W., Kim H.S., Oh B.H.: Nitric oxideinduced apoptosis is mediated by BAX/Bcl-2 gene expression, transition of cytochrome C, and activation of caspase-3 in rat vascular smooth muscle cells. Clin Chim Acta 2004, 341 , 83-91. 3. Cherla G., Jaimes E.A.: Role of L-arginine in the pathogenesis and treatment of renal disease. J Nutr 2004, 134 , 2801

-chain amino acids in normal and muscle-atrophying rats. J Nutr 2006, 136, 234-236. 15. Lalani R., Bhasin S., Byhower F., Tarnuzzer R., Grant M., Shen R., Asa S., Ezzat S., Gonzalez-Cadavid N.F.: Myostatin and insulinlike growth factor-I and -II expression in the muscle of rats exposed to the microgravity environment of the NeuroLab space shuttle flight. J Endocrinol 2000, 167, 417-428. 16. Lee J.W., Kim N.H., Milanesi A.: Thyroid hormone signaling in muscle development, repair and metabolism. J Endocrinol Diabetes Obes 2014, 2, 1046-1054. 17. Morrison W.L., Gibson J

treatment of sepsis ( 22 ). The objectives of our study were to evaluate the effects of hypothermia on oxidative stress state (the activity of SOD and GPx, lipid peroxidation level, and total protein and protein oxidation levels) in hepatic and renal tissue in rats where CLP sepsis was induced. Also, in order to accurately illustrate the oxidative modifications produced at the lipid level, a profile of the different classes of fatty acids in the total lipid extracts obtained from the tissues was analysed. Material and Methods Chemicals and reagents. All chemicals and

al. D-23129: a new anticonvulsant with broad spectrum activity in animal models of epileptic seizures. Epilepsy Res. 1996;23(3):211-23. 8. Sander SE, Lemm C, Lange N et al. Retigabine, a Kv7 (KCNQ) potassium channel opener, attenuates L-DOPA-induce dyskinesias in 6-OHDA-lesioned rats. Neuropharmacology. 2012;62(2):1052-61. 9. Blackburn-Munro G, Dalby-Brown W, Mirza NR et al. Retigabine: Chemical Synthesis to Clinical Application. CNS Drug Rev. 2005,11(1):1-20. 10. Orhan G, Wuttke TV, Nies AT, Schwab M, Lerche H. Retigabine/Ezogabine, a KCNQ/K(V)7 channel opener