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splicing. Mol Cell Biol. 2007; 27: 8431-41. 10.1128/MCB.00565-07 16. Kim MH. Protein phosphatase 1 activation and alternative splicing of Bcl-X and Mcl-1 by EGCG + ibuprofen. J Cell Biochem. 2008; 104:1491-9. 17. Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, et al. De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem. 2002; 277: 12587-95. 18. Du K, Peng Y, Greenbaum LE, Haber BA, Taub R. HRS/SRp40-mediated inclusion of the fibronectin EIIIB

, these alterations significantly coincide with MYC overexpression in squamous cell carcinoma. PHACTR3 (Phosphatase and actin regulator 3/ scaffold-associated PP1 inhibiting protein), also known as scapinin, is a protein phosphatase 1-binding protein associated with nuclear non-chromatin structures (the nuclear matrix or nucleoskeleton) ( 21 ). It directly interacts with actin and regulates actin cytoskeleton structures influencing cell spreading and motility ( 22 ). At the same time, nuclear F-actin activates transcription of c-Myc through Wnt/β-catenin signaling

kinase A PKG - Protein kinase G PP1 - Protein phosphatase 1 PSA - Prostate-specific antigen sGC - Soluble guanylyl cyclase TRUS - ten-core transrectal ultrasound REFERENCES 1. Boolell M, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, Osterloh IH, Gingell C. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 1996;8(2):47-52. 2. Boolell M, Gepi-Attee S, Gingell JC, Allen MJ. Sildenafil, a novel effective oral therapy for male erectile dysfunction. Br

;421-422:118-23. doi: 10.1016/j. scitotenv.2012.01.053 36. Saqrane S, Ouahid Y, El Ghazali I, Oudra B, Bouarab L, del Campo F. Physiological changes in Triticum durum , Zea mays , Pisum sativum and Lens esculenta cultivars, caused by irrigation with water contaminated with microcystins: A laboratory experimental approach. Toxicon 2009;53:786-96. doi: 10.1016/j.toxicon.2009.01.028 37. MacKintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA. Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS

-F, Swerdel MR, Monticello TM, Durham SK, Minchenko A, Lira SA, Webb ML. Hypoxia stimulates human preproendothelin-1 promoter activity in transgenic mice. Amer J Physiol 273, L848–L855, 1997. Bao N, Fang B, Lv H, Jiang Y, Chen F, Wang Z, Ma H. Upregulation of miR-199a-5p protects spinal cord against ischemia/reperfusion-induced injury via downregulation of ECE1 in rat. Cell Mol Neurobiol 38, 1293–1303, 2018. Boratko A, Vereb Z, Petrovski G, Csortos C. TIMAP-protein phosphatase 1-complex controls endothelin-1 production via ECE-1 dephosphorylation. Int J Biochem Cell Biol 73

. 2003. Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. Molecular and cellular biology, 23(4): 1292–1303. Chow, V. W., Mattson, M. P., Wong, P. C. & Gleichmann, M. 2010. An overview of APP processing enzymes and products. Neuromolecular medicine, 12(1): 1–12. Cole, S. L. & Vassar, R. 2007. The Alzheimer's disease beta-secretase enzyme, BACE1. Molecular neurodegeneration, 2: 22. Cooper, G. M. 2000. The

SwissProt sp|Q5EB30|ODF3A_XENTR Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 TR21606|c0_g1 SwissProt sp|Q9P2D7|DYH1_HUMAN Dynein heavy chain 1, axonemal OS=Homo sapiens GN=DNAH1 PE=2 SV=4 TR275|c0_g1 SwissProt sp|Q6DTY7|F264_MOUSE 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 OS=Mus musculus GN=Pfkfb4 PE=2 SV=4 TR50927|c0_g1 SwissProt sp|Q3UM45|PP1R7_MOUSE Protein phosphatase 1 regulatory subunit 7 OS=Mus musculus GN=Ppp1r7 PE=1 SV=2 GO and KEGG annotations of core genes Six core genes were annotated to 11, 21, and 26 GO terms belonging to

through the induction of IL-10 production and dual specificity protein phosphatase 1 to limit inflammation.[ 49 , 50 ] In contrast to C/EBPα, C/EBPσ induces M1 pro-inflammatory responses in murine BMDMs.[ 51 ] Another member of the C/EBP family, C/EBPα, is believed to be necessary for both M1 and “M2 activation of murine macrophages.[ 52 ] All these studies have suggested a critical role for CREB-C/EBP signaling in regulating heterogeneous activation of macrophages. The lipid metabolism regulator Peroxisome Proliferator-Activated Receptor gamma (PPARγ) can negatively