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-206. 12. Impey S, McCorkle SR, Cha-Molstad H, Dwyer JM, Yochum GS. Defining the CREB regulon: a genomewide analysis of transcription factor regulatory regions. Cell. 2004; 119:1041-54. 13. Maiese K, Chong ZZ, Shang YC. OutFOXOing disease and disability: The therapeutic potential of targeting FoxO proteins. Trends Mol Med. 2008; 14:219-27. 14. Guo S, Rena G, Cichy S, He X, Cohen P, Unterman T. Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity

), peroxiredoxin 6 (Prx6). Fish Shellfish Immunol 2012, 33, 28–35. 6. Fatemi M., Pao M.M., Jeong S., Gal-Yam E.N., Egger G., Weisenberger D.J., Jones P.A.: Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level. Nucleic Acids Res 2005, 33, e176. 7. Liu N.N., Liu Z.S., Lu S.Y., Hu P., Li Y.S., Feng X.L., Zhang S.Y., Wang N., Meng Q.F., Yang Y.J., Tang F., Xu Y.M., Zhang W.H., Guo X., Chen X.F., Zhou Y., Ren H.L.: Full-length cDNA cloning, molecular characterization and differential expression analysis of

’ region of the UGT1A gene. Each of the 13 5’ exons has its own TATA promoter elements. Four of 13 first exons are pseudoexons, and nine exons are viable, independently transcribed as the first exon. Those nine different first exons with highly conserved regions from exon 2 to exon 5, generate nine different transcripts (UGT1A1, UGT1A3 through UGT1A10). Each transcript has identical 3’ ends and a unique 5’ end. Variable first exon provides substrate specificity, while highly conserved common exons contain sites for interactions with UDP glucuronic acid as common

. Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case-control study. J Gen Virol 2008;89:2882-2890. 9 Lu CC, Yen TS. Activation of the hepatitis B virus S promoter by transcription factor NF-Y via a CCAAT element. Virology 1996;225:387-394. 10 Wang HC, Wu HC, Chen CF, Fausto N, Lei HY, Su IJ. Different types of ground glass hepatocytes in chronic hepatitis B virus infection contain specific pre-S mutants that may induce endoplasmic reticulum stress. Am J Pathol 2003;163:2441-2449. 11 Hsieh YH, Su IJ, Wang HC

References Bremer, M., McKibben, B. (2016) Escape the imrpovement trap: five ingredients missiong in most improvement recipes, CRC Press Chavez, H.G., Rasmusson, M. (2018) Investigating Loading Capabilities for Sofas and Armchairs for Domestic Use A case study at a furniture manufacturer , Sweden: Chalmers University of Technology Chernev, A. (2017) The business model: how to develop new products, create market value and make the competition irrelevant, Cerebellum Press Christensen, J.B. (2017) Next-generation net promoter, Lulu.com Duica, M.C. et al

. According to Anderson et al. [2014] , due to the commercial omnipresence of Internet customers, loyalty is harder than ever to achieve. Although customers’ loyalty has been a subject of many studies, there is no consensus on the perfect loyalty measure. One of the recent and modern customer loyalty measures is the net promoter score (NPS). This score is significantly reliant on promoters (i.e., people willing to recommend a product or a company to a friend or a colleague) and detractors, being the opposite [ Reichheld, 2003 ]. Opinions, i.e., word of mouth, of clients

Single nucleotide polymorphisms (SNPs) are estimated to occur in 1 of every 1,000 nucleotides in the human genome [ 1 , 2 ]. Depending on where a SNP occurs, it might have various consequences at the phenotypic level. SNPs that alter the function or structure of the encoded proteins are a necessary and sufficient cause of most of the known recessively or dominantly inherited monogenic disorders. These SNPs are found in the coding regions of genes and are routinely analyzed for medical purposes [ 3 ]. SNPs in the promoter region of genes affect the

Beneficial effects of red wine polyphenols on cardiovascular health are well known. The aim of our research was an interaction study of four red wine polyphenols – resveratrol (R), quercetin (Q), kaempferol (KF) and isorhamnetin (IR) of their ability to activate endothelial NO synthase (eNOS) promoter when used alone and in equimolar mixtures. To determine their activity, we performed a luciferase reporter gene assay on EA.hy926 cells stably transfected with a luciferase reporter gene construct containing eNOS promoter. The Bradford assay was also performed to account the cytotoxicity and/or the cell number differences. The median effect equation, as an interaction analysis evaluating synergy or antagonism of the combinations was done according to mass-action law principle. Isobolographic method was performed on selected double mixtures and dose reduction index was calculated for all mixtures. All single polyphenols activated eNOS promoter. The EC50 values were in micromolar concentrations ranging from 3.44 μM (R2 = 0.96) for kaempferol to 9.89 μM for isorhamnetin (R2 = 0.94). All mixtures activated eNOS promoter, but their interactions varied from synergy (Q+R, Q+IR+KF, Q+R+KF and Q+R+IR+KF), through additive (R+IR+KF) to antagonistic interaction (R+IR, R+KF, Q+IR, Q+KF, IR+KF and R+Q+IR). In this study, we show for the first time that red wine polyphenols activated eNOS promoter when used alone and in mixtures with different type of interactions.

. R., Kinloch A. J., Taylor, A. C. (2014) Durability of asphalt mixtures: Effect of aggregate type and adhesion promoters, International Journal of Adhesion and Adhesives, pp. 100-111. Ebnesajjad, S. (2011) Handbook of Adhesives and Surface Preparation: Technology, Application and Manufactureing, Oxford: Elsevier Inc.. Packham, D. E. (2005) Handbook of Adhesion Second Edition, West Sussex, UK: John Wiley and Sons Ltd. ČSN 73 6161 (2000) Stanovení přilnavosti asfaltových pojiv ke kamenivu. (Determination of adhesion of asphalt binders to aggregates). Brno: ČNI, Mai

cisplatin in glioblastoma multiforme. Clin Cancer Res 2003; 9: 1461-8. Kamiryo T, Tada K, Shiraishi S, Shinojima N, Kochi M, Ushio Y. Correlation between promoter hypermethylation of the O 6 -methylguanine-deoxyribonucleic acid methyltransferase gene and prognosis in patients with high-grade astrocytic tumors treated with surgery, radiotherapy, and 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea-based chemotherapy. Neurosurgery 2004; 54: 349-57. Blanc JL, Wager M, Guilhot J, Kusy S, Bataille B, Chantereau T, et al. Correlation of clinical